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The effect of depression symptoms and social support on black-white differences in health-related quality of life in early pregnancy: the health status in pregnancy (HIP) study
© Liu et al.; licensee BioMed Central Ltd. 2013
Received: 6 July 2012
Accepted: 24 May 2013
Published: 3 June 2013
Lower physical and social functioning in pregnancy has been linked to an increased risk of preterm delivery and low birth weight infants, butt few studies have examined racial differences in pregnant women’s perception of their functioning. Even fewer studies have elucidated the demographic and clinical factors contributing to racial differences in functioning. Our objective was to determine whether there are racial differences in health-related quality of life (HRQoL) in early pregnancy; and if so, to identify the contributions of socio-demographic characteristics, depression symptoms, social support and clinical factors to these differences.
Cross-sectional study of 175 women in early pregnancy attending prenatal clinics in urban setting. In multivariate analysis, we assessed the independent relation of black race (compared to white) to HRQoL scores from the eight domains of the Medical Outcomes (SF-36) Survey: Physical Functioning, Role-Physical, Bodily Pain, Vitality, General Health, Social Functioning, Role-Emotional, and Mental Health. We compared socio-demographic and clinical factors and depression symptoms between black and white women and assessed the relative importance of these factors in explaining racial differences in physical and social functioning.
Black women comprised 59% of the sample; white women comprised 41%. Before adjustment, black women had scores that were 14 points lower in Physical Function and Bodily Pain, 8 points lower in General Health, 4 points lower in Vitality and 7 points lower in Social Functioning. After adjustment for depression symptoms, social support and clinical factors, black women still had HRQoL scores that were 4 to 10 points lower than white women, but the differences were no longer statistically significant. Level of social support and payment source accounted for most of the variation in Physical Functioning, Bodily Pain and General Health. Social support accounted for most of the differences in Vitality and Social Functioning.
Payment source and social support accounted for much of the racial differences in physical and social function scores. Efforts to reduce racial differences might focus on improving social support networks and Socio-economic barriers.
Several investigations show that depressive symptoms and social support are important determinants of health-related quality of life (HRQoL) in pregnant women [1–7]. The generalizability of these investigations, however, has been limited since the majority of studies, both in the United States and worldwide, have been conducted in predominately white and middle-class women. Emmanual and colleagues , for example, reported that social support was a significant and consistent predictor of HRQoL during the perinatal period, but this study was limited to a sample of predominately white women. Fewer studies have examined differences in HRQoL in a racially and socioeconomically diverse sample of pregnant women [5, 8, 9]. Even fewer studies have evaluated the individual and combined influence of explanatory factors (demographic, psychosocial or clinical) on physical, emotional and social functioning during the perinatal period or early pregnancy [5, 10–12]. Darcy and colleagues  reported several factors, including age, black race and marital status, can contribute to postpartum depressive symptoms and poorer HRQoL. Negron and colleagues  found that physical symptom burden and social support were important factors in determining depression symptoms and HRQoL among pregnant minority women.
It is important for prenatal clinicians to be knowledgeable of the factors associated with depression symptoms and limited social support among pregnant women. Lower physical functioning prior to conception  and in early pregnancy  has been linked to an increased risk of preterm birth. Poor emotional functioning has been associated with an increase in prenatal visits, fetal surveillance and resource use . Offspring of women with poorer functioning have worse access and receipt of health care services [15, 16].
The purpose of this study was to determine whether black-white differences in maternal perceptions of HRQoL exist, and if so, to elucidate the effects of depressive symptom level, social support and clinical factors on these differences. We hypothesized that black-white differences in HRQoL would exist in early pregnancy and that depressive symptoms would account for much of these differences. Our objectives were to 1) estimate the magnitude of racial differences in perceived HRQoL in early pregnancy and 2) measure the presence, direction, strength, and independence of explanatory factors on HRQoL. If demographic or socioeconomic factors account for differences between black and white women, the development of targeted social interventions would be indicated. Alternatively, if variations in depressive symptoms account for much of the difference in HRQoL, clinicians might develop strategies to reduce the burden depressive symptoms during the preconception and prenatal period.
Study setting and participant eligibility
The study population consisted of pregnant women participating in the Health Status in Pregnancy (HIP) Study, a longitudinal study of functional status during pregnancy and after delivery among a diverse sample of pregnant women in Baltimore city. This study represents an analysis of the baseline data. Women were recruited at the time of the first prenatal visit (termed “new to nurse” visit) at two outpatient clinics in Baltimore city. Women were eligible for enrollment if they were 1) 18 years of age or older, 2) presented for antenatal care at one of two outpatient settings; 3) intended to maintain their pregnancies and deliver within Baltimore city, 4) 14 weeks gestation or less at the time of enrollment and 5) able to provide written consent in English. Women were excluded if they had a diagnosis of human immunodeficiency virus (HIV) or cancer. The study was approved by the institutional review board.
Recruitment was conducted over a 10-month period between July 24, 2004, and May 31, 2005 with final follow-up in May, 2006, at two university-based outpatient clinics. One clinic was located on the university campus. A second clinic was located in the surrounding community within 2 miles of the university hospital. These clinics provide prenatal care to a racially diverse population and include women with Medicaid and commercial insurance. Written informed consent was obtained from each participant by a trained interviewer.
Gestational age at recruitment was based on the last menstrual period (LMP), first trimester ultrasound assessment if it had already been obtained, or both. Gestational age was later confirmed through a review of the electronic medical record and was based on either the obstetrician’s assessment of the LMP or both the LMP and obstetric ultrasound assessment. If there was a discrepancy between the gestational age by LMP and ultrasound, then the gestational age determined by ultrasound was assigned to the participant.
HRQoL was measured using the Medical Outcomes Survey Short Form (SF-36),  a multidimensional measure of health status designed for self or interviewer administration. The SF-36 has been validated in pregnant women and has been shown to be a reliable tool . There is internal consistency for the SF-36 in the general population (Cronbach’s alpha >0.8), disadvantaged subgroups (> 0.70),  and postpartum women (> 0.70). The questionnaire measures perceptions of Physical Functioning, Role-Physical, Bodily Pain, General Health, Vitality, Role-Emotional, Social Functioning and Mental Health. Physical Functioning measures the extent to which health interferes with a variety of physical activities. Role-Physical measures problems with work or other daily activities as a result of physical health. Bodily Pain assesses the extent of bodily pain and related limitations. General Health is a personal evaluation of general health. Vitality provides the perception of degree of fatigue or energy. Social Functioning measures the extent to which health interferes with normal social activities. Role-Emotional reflects problems with work or other activities as a result of emotional problems. Mental Health reflects general mood, psychological well-being, or distress. 1) Responses to questions are scored on a 5-point scale. These absolute scores are then transformed into a score between 0 and 100, with higher scores indicating better functioning or well-being. A score of 100 represents optimal health.
Maternal race, was based on maternal self-report at the time of presentation for prenatal care. Study participants were classified as: 1) non-Hispanic whites, 2) non-Hispanic blacks, 3) Asian/Pacific Islanders, 4) American Indians, and 5) “other.”
Socio-demographic variables were abstracted from electronic patient records at baseline and included maternal age, marital status and parity. Socioeconomic factors included employment status (employed, unemployed) at time of study, years of education (less than 12 years, 12 years or more) and insurance (Medicaid, commercial).
Depressive symptoms were measured using the Center for Epidemiologic Studies Depression (CES-D) Scale. The Center for Epidemiologic Studies Depression Scale is a 20-item self-report instrument developed by the National Institute of Mental Health to assess depressive symptoms among samples drawn from communities . The reliability and validity of the CES-D Scale in diverse populations are well established [20, 21]. There is internal consistency for the CES-D Scale in both the general population (Cronbach’s alpha = 0.84) and among postpartum women (0.88–0.91) . The Scale allows respondents to indicate the presence of depressive symptoms, such as sadness, crying, hopelessness, or changes in appetite or sleep. The CES-D Scale has a sensitivity of 80–90% in primary care settings with a cutoff of 16 or more. Prior studies have used the CES-D Scale in pregnancy with a moderate sensitivity of 80%  and a specificity of 98-99% [1, 23]. The CES-D was used in the current study because it was the primary tool used by providers at each of the clinical sites as part of their prenatal assessments. Also, using the CES-D provided an opportunity to compared results in pregnant women with general populations of childbearing women using a similar instrument to that used in primary care practices. Items on the CES-D Scale are rated on a zero-to-three point response scale. A total score is determined by summing the ratings across all 20 items, with possible scores ranging between 0 and 60. The standard threshold of 16 or greater has been used as an indicator of clinically significant elevations in depressive symptoms in community samples as well as in pregnant women . Forty to fifty percent of individuals with scores at or above 16 would be classified as clinically depressed.
Social support was assessed at baseline with using three questions adapted from the Norbeck Social Support (NSSQ) Questionnaire (questions 1,4, and 9) . The NSSQ is an instrument developed for use in pregnancy and allows subjects to list and rate their own social support network by naming persons available for support and then indicated how much support is available from these individuals in daily situations. The reliability and validity of the NSSQ in diverse populations is well established. There is internal consistency in diverse groups of women (Cronbach’s alpha = 0.88-0.91). Participants were asked the following questions: (1) “Do you get emotional support from your spouse/boyfriend/significant other?” (2) “How much of your support is provided by your spouse/boyfriend/significant other?” and (3) “Who provides most of your emotional support?”
Clinical factors included gestational age, body mass index (BMI) at baseline, prior adverse birth outcomes (preterm birth or spontaneous abortion), past medical conditions and current pregnancy complications. Prior medical conditions were abstracted from electronic medical records at the time of entry into the study and included chronic hypertension, heart disease, diabetes mellitus, sexually transmitted disease, infertility, renal disease, asthma and prior diagnosis of depression. Current pregnancy complications included hypertension, heart disease and asthma, cervical dysplasia requiring colposcopy, pyelonephritis, first or second trimester vaginal bleeding, sexually transmitted disease (gonorrhea, chlamydia, syphilis, hepatitis B) or the diagnosis of depression. Due to small numbers prior medical conditions and current pregnancy-related complicated were re-categorized as composite variables and modeled as dichotomous variables (none versus one or more).
Socio-demographic and clinical factors were compared between black and white women using the χ2 statistic for categorical factors (e.g. marital status) and t test for continuous variables (maternal age, gestational age, BMI). Although functional status scores were not normally distributed, the results did not differ with use of nonparametric (Wilcoxon rank-sum test) versus parametric (t test) methods. Thus, for ease of interpretation, we present our findings as mean HRQoL scores and 95% confidence intervals. With an alpha of 0.05, there was over 80% power to detect a six point difference or higher in health-related quality of life scores among women in the two racial groups. A difference of six or more points is considered to be an important clinical difference in functioning . In bivariate analysis, we measured the association of demographic and clinical factors, depressive symptoms and social support with maternal HRQoL scores, using analysis of variance. Potential collinearity between socio-demographic variables was examined using a correlation matrix (p = 0.7) and the variance inflation factor.
The presence, magnitude and direction of association of each category of explanatory variables with each domain of health-related quality of life were estimated using multiple linear regression analysis. Each regression coefficient represents, on average, the direction and magnitude of difference in functional status scores between black and white women. Separate linear regression models were developed for each of the eight dimensions of functional status. Variables for the multivariate models were selected on the basis of a priori hypotheses or bivariate associations. In a stepwise fashion, groups of explanatory (predisposing, enabling and clinical) variables were added to the model according to the Institute of Medicine access to care model:  first, predisposing variables (age, race, marital status, parity) enabling factors (payment source, education, employment status), third psychosocial factors (depressive symptom level, presence and extent of social support,) and finally clinical factors (gestational age, BMI, history of one or more prior preterm births or spontaneous abortions one or more prior medical conditions, presence of one or more current medical conditions). Multivariate analysis was conducted with and without the participant with a prior history of depression and there was no substantial difference in the adjusted regression coefficients. The Bonferroni correction was used to adjust for multiple testing . The individual contribution of each explanatory factor to the models was assessed by the amount of variation explained (r2). P-values less than 0.05 were considered significant. All analyses were conducted using STATA statistical software (Release 9).
Predisposing, enabling, psychosocial and clinical factors by patient race in the Health Status in Pregnancy (HIP) study (N = 175)
(N = 103)
(N = 72)
Age, yrs, mean ± SD
25 ± 0.6
33 ± 0.6
1 prior birth
≥ 2 prior births
< 0. 001*
Support by significant other
Amount of support
Little or moderate
A great deal
Most support other than significant other
Body mass index, mean ± SD
27.8 ± 8
23.2 ± 6.1
Gestational age (mean ± SD weeks)
11 ± 3
8 ± 4
Prior preterm birth or spontaneous miscarriage
≥ 1 Prior medical conditions4,5
≥ 1 Pregnancy complications6
Racial differences in HRQoL scores
Health-related quality of life scores in early pregnancy by race, the Health Status in Pregnancy (HIP) study
Black (n = 103)
White (n = 72)
Mean (95% CI)
Mean (95% CI)
Factors associated with physical functioning
Association of race with physical functioning, role-physical, bodily pain and general health in early pregnancy: the Health Status in Pregnancy (HIP) study
Black versus white race
[Beta coefficient1(95% confidence interval)]
Model 1: Unadjusted
−14┼ (−20, -7)
−8┼ (−19, -4)
−14 ┼ (−20, -7)
−8 ┼ (−12, -4)
Model 2: model 1 + demographic factorsa
−10┼ (−18, -1)
−6 (−21, 9)
−7 (−15, 1)
−5┼ (−10, -0.8)
Model 3: model 2 + socioeconomic factorsb
−10┼ (−17, -0.8)
−6 (−21, 8)
−7 (−16, 0.7)
−6┼ (−10, -1.0)
Model 4: model 3 + depressive symptoms
−9┼ (−17, -1.0)
−6 (−21, 10)
−15┼ (−16, -1)
−5┼ (−10, -0.6)
Model 5: model 4 + social supportc
−11┼ (−20, -2)
−12┼ (−29, 6)
−10┼ (−20, -0.3)
−5┼ (−10, -0.3)
Model 6: model 5 + pre-pregnancy BMI
−10┼ (−19 -0.05)
−13 (−31, 6)
−9 (−19 1.1)
−5 (−10, 0.2)
Model 7: model 6 + prior adverse birth outcomesd
−10 (−20, 0.8)
−15 (−31, 3)
−9 (−19, 1)
−5 (−10, 0.8)
Model 8: model 7 + past medical conditionse
−11┼ (−21, -0.2)
−17 (−36, 1)
−5 (−10, 2)
Model 9: model 8 + current pregnancy Complicationsf
−10 (−20, 0.06)
−18 (−37, 1)
−10 (−20, 0.6)
−5 (−10, 2.0)
Factors associated with social functioning
Association of race with vitality, social functioning, role-emotional and mental health in early pregnancy: the Health Status in Pregnancy (HIP) study
Black versus white race
[Beta coefficient1(95% confidence interval)]
Model 1: Unadjusted
−4┼ (−8, -0.3)
- 7┼ (−14, -0.2)
−8 (−18, 3)
−3 (−8, 2)
Model 2: model 1 + demographic factorsa
−2 (−7, 3)
−5 (−14, 3)
−1 (−13, 14)
−2 (−8, 5)
Model 3: model 2 + socioeconomic factorsb
−2 (−7, 3)
−6 (−14, 3)
−1 (−15, 13)
−2 (−8, 4)
Model 4: model 3 + depressive symptomsc
−2 (−7, 3)
−5 (−13, 4)
3 (−9, 17)
−0.8 (−7, 6)
Model 5: model 4 + social support factorsd
−4 (−10. 0.2)
−8 (−16, 1)
2 (−11, 15)
−0.2 (−7, -6)
Model 6: model 5 + pre-pregnancy BMI
−4 (−10, 0.5)
−9 (−18, 0.4)
−1 (−15, 12)
−0.7 (−7, 5)
Model 7: model 6 + prior adverse birth outcomese
−4 (−10, 1)
−8 (−18, 1.3)
−2 (−16, 12)
−0.8 (−8, 6)
Model 8: model 7 + chronic medical conditionsf
−4 (−10, 1)
−8 (−18, 0.8)
−2 (−16, 12)
−0.7 (−8, 7)
Model 9: model 8 + current medical conditionsg
−4 (−10, 2.0)
−9 (−19, 0.8)
−0.25 (−14, 15)
−0.08 (−7, 6)
While many studies document racial differences in medical outcomes, elucidating or excluding pathways to explain these differences can assist in the development of interventions to eliminate them. This paper summarizes the findings from a cross-sectional study using an established survey validated in pregnant women,  to better understand the relation of race with HRQoL during early pregnancy. Racial differences were identified in Physical Functioning, Bodily Pain, General Health, Vitality and Social Functioning. After adjustment for potential confounders, the differences in HRQoL scores were no longer statistically significant. Incremental adjustment (Table 3 and Table 4) indicated that much of the racial variation in physical functioning was due to insurance status and social support. Variation in social functioning was largely explained by the presence of social support.
Recent studies have emphasized the importance of HRQoL within the broader context of maternal health, pregnancy outcomes and neonatal growth and development. If poor functioning in pregnancy is associated with an increased risk of preterm birth [14, 28] and higher resource utilization, [29, 30] substantive prenatal interventions should be explored. A multidisciplinary approach to improving quality of life includes clinicians, social workers, and community resources, may be needed to promote better functioning during the course of pregnancy. The development of preconception-based interventions that address social support and depression symptoms before conception and extend into the early pregnancy period, may prove effective at increasing early pregnancy functioning.
The findings of this study are largely consistent with other studies in non-pregnant adults that report lower ratings of quality of life among blacks compared to whites [31, 32]. In contrast to other studies, however, the presence of medical conditions did not appear to have a substantial effect on HRQoL among women in early pregnancy. There were no statistically significant racial differences in the prevalence of chronic or current medical conditions in our sample of women. Moreover, adjustment for chronic or current conditions did not contribute substantially to the overall variation in physical or social functioning between racial groups. It may be that the effect of pregnancy-specific complications on physical and social functioning is cumulative and increases over the entire course of pregnancy, rather than contributing to a substantive effect in early pregnancy. Alternatively, both black and white women may expect to experience symptoms related to medical conditions or some physical discomfort during pregnancy, with the result that it does not influence their perception of their health-related quality of life.
Social support accounted for a modest amount of the variation in each dimension of physical functioning. Perceived social support has been correlated with depressive symptoms in some studies, particularly among pregnant women [33–35]. It may be that the black women in our study had different perceptions of partner support compared to white women. Social support networks other than spouses or significant others should be considered in future studies of psychosocial factors and their relation to perceptions of quality of life. Because racial differences in patients’ attitudes and preferences for management of psychosocial issues have been reported, [36–38] health care providers caring for expectant mothers should consider patients’ cultural, social and socioeconomic context when negotiating referrals for psychosocial interventions [37, 39]. Peer-mentoring among first-time mother has been shown to be effectively in improving infant health [40, 41]. Proposed interventions might include similar peer support groups where women can interact with other mothers experiencing depressive symptoms or mothers with a prior history of depression symptoms.
Differences in depressive symptoms between black and white women in our study is similar to other studies among pregnant women [8, 42]. Orr and colleagues reported in the rural south that 49% of Black women had CES-D scores of 16 or greater compared with 33% of white women, corresponding to a difference of 16 percentage points . In our sample, there was a 15 percentage point difference between black and white women (22% versus 7%). Findings from the current study confirm that depressive symptoms are prevalent in early pregnancy among a diverse population and suggest the need for effective and efficient screening measures .
There are several limitations of this study. First, because the sample included only black and white women from one urban area, the findings may not be generalizable to women of other racial groups or in other geographical regions. However, this survey has been established as a reliable instrument for measuring functional status and has been used in multiple populations in health services research. Depressive symptoms were measured rather than the diagnosis of clinical depression. However, subclinical depression, as a consequence of its high prevalence, is a significant clinical problem as manifested by its effect on health service use and social morbidity among adults in the general population, and our measure is one that has been well validated in numerous populations and settings. Also, there were other potential confounders we were unable to adjust for in the analysis (e.g. domestic violence) that might alter the presence or magnitude of associations between race and HRQoL. Regressions models were adjusted for the presence and level of partner support, but support from other sources than the partner was (e.g. family members, neighbors) was not collected or adjusted for in the multivariate analysis. The linear regression models were also not adjusted for women’s pre-pregnancy lifestyle behaviors or desire for pregnancy on physical and mental functioning during pregnancy. Future studies might assess the influence of pregnancy intent on physical and mental functioning during pregnancy. Rather than adjusting for past and current medical conditions individually in the regression analysis, these conditions were adjusted for as a composite variable (one or more medical conditions versus none). This composite variable is heterogeneous and may have reduced the magnitude of association of race with quality of life, as some conditions may have a greater impact on quality of life than others.
The findings of this study show that health-related quality of life in early pregnancy deserves further attention. Comprehensive assessment of psychosocial factors during the first prenatal visits can improve functional status in early pregnancy and could affect perceptions of quality of life throughout the course of pregnancy. Training prenatal providers to assess social support and depressive symptoms can serve to improve women’s perceptions of their quality of life. Prenatal providers might collaborate with mental health providers and social work personnel to address physical and social functioning in pregnant women.
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