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Clinical consequences of gestational diabetes mellitus and maternal obesity as defined by asian BMI thresholds in Viet Nam: a prospective, hospital-based, cohort study



Gestational Diabetes Mellitus (GDM) is common in South East Asia, occurring at relatively lean Body Mass Index (BMI). Outside pregnancy, cardiometabolic risks increase at lower BMI in Asian populations, justifying Asian-specific thresholds for overweight and obesity. We aimed to explore the effects of GDM and obesity on perinatal outcomes using a WHO expert consultation-recommended Asian-specific definition of obesity.


This is a secondary analysis of a prospective, hospital-based, cohort study in Ho Chi Minh City. Participants were recruited from antenatal clinics between 19+ 0-22+ 6 weeks gestation and followed until delivery. GDM screening occurred between 24 and 28 weeks using WHO criteria. Obesity was defined as BMI ≥ 27.5 kg/m2, based on weight and height at recruitment. We assessed associations between GDM (singly, and in combination with obesity) and perinatal outcomes. Participants were categorised into four groups: no GDM/non-obese (reference group), GDM/non-obese, no GDM/obese and GDM/obese. Outcomes included primary caesarean section, hypertensive disorders of pregnancy (HDP), large-for-gestational-age (LGA), birth weight, preterm birth, and composite adverse neonatal outcome. Logistic and linear regressions were performed with adjustment for differences in baseline characteristics.


Among 4,970 participants, 908 (18%) developed GDM. Compared to women without GDM, GDM increased risks for preterm birth (OR: 1.40, 95% CI: 1.09–1.78), higher birthweight (birthweight z-score 0.16 versus 0.09, p = 0.027), and LGA (OR 1.14, 0.89–1.46). GDM without obesity was associated with an increased risk of preterm birth (OR 1.35, 1.04–1.74). Obese women without GDM were more likely to deliver by caesarean section and have an LGA baby (1.80, 1.33–2.44 and 2.75, 1.88–4.03). The highest risks were observed amongst women with both GDM and obesity: caesarean Sect. (2.43, 1.49–3.96), LGA (3.36, 1.94–5.80) and preterm birth (2.42, 1.32–4.44).


GDM was associated with an increased risk of preterm birth and larger newborn size. Using an Asian-specific definition of obesity, we demonstrate obese women with GDM are at the highest risk of adverse outcomes. Using a BMI threshold in pregnancy of 27.5 kg/m2 (between 19 and 22 weeks gestation) for Asian women can identify women who will benefit from intensified diabetes, nutritional, and obstetric care. This has relevance for obstetric service delivery within Asia, and other health systems providing pregnancy care for Asian expatriate women.

Peer Review reports


Gestational Diabetes Mellitus is associated with adverse pregnancy outcomes (preterm birth, larger newborn size at birth, and caesarean section). These outcomes are exacerbated by obesity (as defined by Asian BMI thresholds) in a Vietnamese population.


Gestational diabetes mellitus (GDM) is the new onset of glucose intolerance during pregnancy and affects around 15% of pregnancies worldwide, equivalent to 21 million births annually [1, 2]. GDM is usually diagnosed about 24–28 weeks gestation, with the diagnostic gold standard being the oral glucose tolerance test (OGTT). GDM can lead to complications during pregnancy and birth [3], including increased need for delivery by Caesarean section (C-section), hypertensive disorders of pregnancy (HDP) and large-for-gestational-age (LGA) babies. Associations with other adverse neonatal outcomes have been less consistently demonstrated [4,5,6].

For decades there has been controversy over glycaemic thresholds used to define GDM. The WHO/IADPSG criteria for diagnosis of GDM was released following the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) Study [7], and is based on the risk of adverse perinatal outcomes [8].

To date, most research on the consequences of GDM has been conducted in western populations. GDM is common in South-East Asia (SEA), affecting up to 18% of pregnant women [9], however adverse outcomes have been less consistently observed. For example, two studies reported no association between GDM and C-Sects. [10, 11], and only weak associations with pregnancy-induced hypertension and LGA babies [11, 12]. These differences could be due to study design, genetic, metabolic, behavioural, or therapeutic differences. However, it is notable that women in SEA with GDM usually have much lower BMIs than their western counterparts, upon whom much of our understanding of GDM is based.

During pregnancy, obesity and GDM are found to act synergistically to increase the risk of adverse perinatal outcomes in Western populations [13]. However, as populations across Asia experience economic and nutritional transition, the proportion of people living with obesity is increasing. The effects of this on population health are concerning, particularly as cardiometabolic complications occur in Asian populations at relatively lower BMI than people with European (white) ancestry [14]. During pregnancy, the adverse consequences of GDM associated with obesity could follow this pattern, with increased risk observed at BMI levels below the WHO definition of obesity (30 kg/m2).

Therefore, we aim to examine the association between GDM and adverse pregnancy outcomes and explore how obesity, (using a definition of BMI ≥ 27.5 kg/m2 as recommended by a WHO expert consultation for Asian populations) modulates these risks in an Asian (Vietnamese) urban population.


The current study is a secondary analysis from the Viet Nam Preterm Birth Biomarkers (PBB) Project. The PBB was a prospective cohort study conducted between October 2016 to October 2018 in Tu Du Hospital in Ho Chi Minh City, the largest maternity hospital in Viet Nam. Viet Nam is a rapidly developing country with a population of 90 million, GDP per capita of USD 10,755 (Purchasing Power Parity) in 2020, and a maternal mortality ratio of 211 per 100,000 live births in 2017 [15].

From October 2016 until May 2018, women between 19+ 0 to 22+ 6 weeks gestation were recruited from the hospital’s antenatal outpatient service. Inclusion criteria were maternal age > 18 years, singleton pregnancy, intention to deliver at Tu Du Hospital, ability to give written informed consent, certainty in pregnancy dating from ultrasound scan < 14 weeks gestation, and no signs or symptoms of a threatened miscarriage. Participants were followed up through pregnancy, labour and birth, until the last mother-newborn pair was discharged (last participant October 2018). For this secondary analysis, further exclusions were applied to women who delivered at < 24 weeks gestation (as this preceded the gestation of GDM diagnosis).

The primary exposure for this study was GDM, studied both singly and in combination with obesity. We felt this two-step approach in studying these risk factors (GDM and obesity) is appropriate as GDM has a high prevalence in Asian populations so it is important to look at its associated adverse outcomes. However, it is also important to isolate any independent effects of BMI, particularly given the metabolic overlaps between GDM and obesity.

GDM screening is universal in this hospital as part of routine clinical care. GDM was defined using the IADPSG/WHO criteria (fasting ≥ 5.1 mmol/L; 1-hour ≥ 10.0 mmol/L; 2-hour ≥ 8.5mmol/L). The diagnosis was by 75-gram OGTT between 24 and 28 weeks gestation. BMI was measured from height and weight measurements collected at recruitment (19+ 0 to 22+ 6 weeks gestation). Height was measured using an Adult Stadiometer (Seca 242 Digital Display), and weight measured using an Adult Scale (Seca 877 Portable Digital Scale) at recruitment. The definition of BMI in Asian populations is controversial [14]. In 2004 a WHO expert group published recommendations for BMI thresholds for overweight and obesity for Asian populations. This concluded that despite differences in the BMI where cardiometabolic risk was increased, as there were no consistent thresholds, the universal definition of obesity should be used. However within this document, Asian-specific trigger points for public health action were given (underweight < 18.5 kg/m2, normal 18.5–23 kg/m2, overweight 23-27.5 kg/m2, obese ≥ 27.5 kg/m2) [14]. Given the possibility that adverse consequences associated with obesity could be occurring at lower BMI in this population, we used the Asian trigger point definitions of BMI category for this study.

To study the associations of GDM and obesity in combination, participants were divided into four mutually exclusive groups: (1) no GDM, no obesity; (2) GDM, no obesity; (3) no GDM, obesity; and (4) GDM, obesity. Multivariable logistic regression was used to study the association of GDM and obesity on the three most common adverse outcomes (any C-section, LGA, and preterm birth). Women with no GDM and no obesity were used as the reference group.

We excluded women with pre-existing diabetes (either Type 1 or Type 2 Diabetes). Potential confounding exposures included: maternal age, gestational weight gain from either self-reported pre-pregnancy or weight measured early in conception until recruitment, socioeconomic status (using occupation as a proxy measure), parity, history of hypertension, and history of preterm birth.

Maternal and newborn outcomes associated with GDM were selected based on previously observed associations ranked by consensus [16]. Outcomes assessed were: primary C-section, any C-section (including women who delivered by C-section in earlier pregnancies); HDP including either gestational hypertension (systolic BP ≥ 140 mmHg, diastolic BP ≥ 90 mmHg), pre-eclampsia, eclampsia, or HELLP (haemolysis, elevated liver enzymes, and low platelets); and newborn size at birth using birthweight, birth weight z-score, LGA and SGA (small-for-gestational-age), defined respectively as > 90th and < 10th percentile according to the INTERGROWTH-21st Newborn Size Standards for gestational age at birth and newborn sex [17]. Macrosomia was defined as birthweight > 4000 g. Preterm birth was defined as delivery at < 37 weeks gestation. We used a composite indicator of a severe neonatal adverse outcome as per the ACHOIS Study [18], comprising: stillbirth, neonatal death before discharge, neonatal intensive care unit (NICU) admission, fractured clavicle, transient tachypnoea, or respiratory distress syndrome.

All data were recorded by trained research midwives on paper case record forms and electronically transcribed. Data were collected at two time points: recruitment, and after birth before discharge from the hospital. Trained research midwives interviewed the women at each visit, with medical details obtained from medical records. Women who delivered in other hospitals were interviewed by telephone for basic delivery information. Data were transcribed and stored in a secure database (CliRes).

The sample size was based on the PBB study’s primary objectives. Post hoc, we estimated that for 900 women with GDM compared to 4,000 controls, for outcomes at 5% prevalence in the control group, a risk difference of 2% could be demonstrated, with 80% power and statistical significance set at a two-tailed p-value of < 0.05.

Participants loss-to-follow-up were excluded, yielding a complete case analysis. As loss-to follow-up rates were extremely low (0.2%), no imputation was performed for missing values. For weight-related outcomes (LGA and weight z-score), implausible outliers for weight z-score with > or < than three standard deviations (SD) from the mean were dropped. Participant recruitment and subsequent exclusion are presented in a flow diagram.

Univariate analyses used Student T-test for normally distributed variables, Mann-Whitney U-test for skewed continuous variables, chi-squared test of homogeneity for categorical variables, and chi-squared test for linear trend for ordinal variables. A 5% two-sided significance level was used for all p-values. Box-and-whisker plots were constructed for newborn weight (grams) and weight z-score. Multivariable logistic regression reported Odds Ratios (OR), and multivariable linear regression reported beta coefficients with 95% confidence intervals (CI). Continuous variables were checked for the assumption of log-linear association by testing for departure from linearity using the Likelihood Ratio Test. Covariates that showed a significant association with both exposure and outcome and were not on the causal pathway were assessed for confounding using the chi-squared values from the Likelihood Ratio Test of each serial adjustment for covariates with and without the primary exposure. This helped to gauge how much statistical information the primary exposure contributed to model fit. The decision for adjusting for relevant confounders were informed by both statistical criteria and biological plausibility based on our clinical knowledge and understanding of the literature, Variance Inflation Factors were used to check for multicollinearity, and model diagnostics for linear regression included homoscedasticity, assumption of linearity, and normality of residuals.

To assess the potential of unmeasured confounders explaining away an observed association, the E-Value was computed for outcomes with evidence of significant association [19].

All analyses and plots were performed using STATA 16.1 (StataCorp LLC, Texas, USA).


From 10,711 pregnant women screened, 5,000 met the PBB entry criteria and gave consent for participation. After enrolment, 12 women were loss-to-follow-up, and four withdrew. In addition, we excluded nine women with pre-existing diabetes and five who delivered < 24 weeks gestation, leaving 4,970 women and babies for analysis, Fig. 1.

Fig. 1
figure 1

Flow Diagram of Study Participants. † Gestational Diabetes Mellitus; flow diagram showing participant recruitment from enrolment to corresponding numbers of women who were and were not diagnosed with gestational diabetes. Reasons and number of exclusions are stated accordingly

Cohort characteristics

There were 908 women (18%) diagnosed with GDM, of whom 19 (2%) were treated with insulin.

The mean BMI was 22.5 kg/m2 in women without GDM, compared to 23.5 kg/m2 in those with GDM (p < 0.001). Among the 267 (5.4%) women classified as obese as per the Asian threshold (27.5 kg/m2); 189 (4.7%) did not have GDM, while 78 (8.6%) had GDM. Among the 1,895 women classified as overweight as per the Asian threshold (23–27.5 kg/m2); 1,466 (36%) did not have GDM, while 429 (47%) had GDM. Among 4,970 women, 78% were neither diagnosed with GDM nor obese, 17% had GDM but were not obese, 3.8% did not have GDM but were obese, and 1.6% had both GDM and obesity. Compared to women without GDM and who were not obese, women with GDM and were obese were significantly older (p < 0.001), Table 1. A similar trend was also seen in gestational weight gain; women with GDM and obesity gained on average 2 kg more weight by recruitment (around 21 weeks gestation), (p < 0.001). In order to account for the fact that women were recruited at slightly different gestational ages (19–22 weeks), we also looked at the average weight gain per week throughout gestation, and this difference remained significant; obese and GDM women gained more weight per week than women without GDM and not obese (p < 0.001). In addition, obese women with GDM were more likely to have had a history of hypertension compared to women who had neither GDM nor obesity (3.9% versus 0.2%, p < 0.001). Women with both GDM and obesity were also more likely to be multiparous compared to those women with neither GDM nor obesity (60% versus 45%, p < 0.001), as well as more likely to have a history of giving birth to a macrosomia baby/ies; 11% versus 2%, p < 0.001.

Table 1 Maternal Baseline Characteristics by Gestational Diabetes Mellitus and Obesity Status

Maternal outcomes

Women with GDM experienced similar rates of primary C-section compared to those without GDM (35% versus 33% respectively, p = 0.3), Table 2. More women with GDM experienced severe pre-eclampsia, eclampsia or HELLP than women without GDM (1.3% versus 0.6%, p = 0.03). However, after adjustment for confounders, this difference was no longer significant (OR: 1.42, CI: 0.70–2.87).

More women with GDM delivered preterm (11% in GDM compared to 8% in non-GDM women, p = 0.002), and this association remained significant after adjustment for potential confounders; GDM-women were at 40% significantly increased odds of delivering preterm (OR: 1.40, CI: 1.09–1.78).

Table 2 Univariate and Multivariable Analysis of Maternal Outcomes by Gestational Diabetes Mellitus Status

Neonatal outcomes

The proportion of male babies was 52% and 50% in non-GDM and GDM-women, respectively. Whilst the mean birth weight was similar, after accounting for gestational age and gender, babies exposed to GDM had higher birthweight z-scores (0.16 compared to 0.09, p = 0.03), Fig. 2.

Fig. 2
figure 2

Newborn Weight by Mothers with and without Gestational Diabetes Mellitus. GDM (Gestational Diabetes Mellitus); box and whisker plot showing newborn weight (in grams) and newborn weight z-score (adjusted for gestational age at birth and newborn sex) born from mothers with and without GDM

Babies exposed to GDM were also more likely born macrosomia (unadjusted OR 1.48, CI 1.05–2.08), or LGA (unadjusted OR 1.33, CI 1.05–1.69), Table 3. However, after adjustment for other confounders (maternal age, BMI, gestational weight gain, socioeconomic status, parity), a null effect could not be excluded.

Table 3 Univariate and Multivariable Analysis of Neonatal Outcomes by Gestational Diabetes Mellitus Status

No significant differences were observed in the individual components of neonatal mortality or severe morbidity. There was no difference in the overall composite neonatal adverse outcome (6% in non-GDM and 7% in GDM women, p = 0.2) or risk of NICU admission in babies born to women with GDM (5% in non-GDM and 6% in GDM women, p = 0.2), Table 3. Two babies suffered a fractured clavicle at birth; however, both were born to non-GDM mothers.

Relationship between obesity, GDM and adverse outcomes

Overall, 267 (5.4%) women were classified as obese as per the Asian threshold, and these women were overrepresented amongst the GDM group 8.6%, compared to non-GDM 4.7%, p < 0.001. Compared to women without GDM or obesity, non-obese women with GDM were at increased risk of preterm birth (OR 1.35), but not C-section or LGA, Fig. 3. This contrasts with the risks observed in women who were obese without GDM. C-section and LGA were increased (OR 1.80 and 2.75), and whilst the point estimate for the risk of preterm birth was similar to in the non-obese women with GDM, a null effect cannot be excluded as the confidence interval crosses 1. The most significant risks however were observed amongst the women with both GDM and obesity. In these women, the risks of C-section, LGA and preterm birth were all increased (OR 2.43, 3.36 and 2.42, respectively).

Fig. 3
figure 3

Relationship between Maternal Gestational Diabetes Mellitus, Obesity (defined: BMI ≥ 27.5 kg/m2), and Perinatal Outcomes. C-section adjusted for age and socioeconomic status; Large for Gestational Age adjusted for age, socioeconomic status, parity; Preterm Birth adjusted for age, socioeconomic status, parity, history of preterm birth

The E-Value for GDM’s impact on preterm birth was 2.15, and for GDM and obesity’s collective impact on C-section, LGA, and preterm birth was 2.49, 3.07, and 2.49, respectively. These E-Values affirm the validity of these estimates, indicating they are relatively robust against unmeasured confounding.


This study aimed to elicit the burden of GDM (both singly and in combination with obesity) on adverse perinatal outcomes in an urban Asian population. As such, we used Asian-specific cut off points for BMI, as recommended by the WHO in order to more accurately reflect the synergistic adverse impact of obesity. We present evidence that women and babies affected by GDM in Ho Chi Minh City experienced higher preterm birth and were born LGA. The most striking associations however were amongst women who had GDM and were also obese, in whom the risks of C-section, LGA and preterm birth were all increased. The overall prevalence of GDM in this study was high (18%), consistent with other reports from SEA populations [9].

We add new insights into the synergistic effects of BMI, specifically obesity on perinatal outcomes, defined using an Asian specific threshold. We demonstrate that obesity, defined ≥ 27.5 kg/m2, and GDM act synergistically towards three pregnancy outcomes: C-section delivery, LGA, and giving birth preterm. Whilst this is consistent with the risks in obese women with GDM reported by the HAPO group [20], it is notable in our study that these risks were observed at a much lower BMI threshold (27.5 versus 33 kg/m2). BMI was calculated in our study at 19–22 week’s of gestation rather than before pregnancy, meaning that potentially adverse effects would have been observed at even lower pre-pregnancy BMIs. Among women who were both GDM and obese, we observed an increased risk for C-section delivery of 2.43, compared to 1.71 in the HAPO cohort, and the risk of delivering an LGA baby was 3.36 compared to 3.62 [20]. While the timing of the BMI measurements differed between our study and the HAPO cohort (19–22 weeks in this study versus 24–32 weeks gestation), we feel it is unlikely that weight gain between these gestations could account for the difference in BMI thresholds we observed (6 kg/m2). Our study supports the hypothesis that adverse maternal and fetal metabolic effects of GDM that are associated with obesity occur at lower BMI in Asian women.

This finding is consistent with observations outside pregnancy [21] and has implications for risk stratification in antenatal care. Asians have a higher percentage of body fat at the same BMI than their European (white) counterparts, with percentage body fat 3–5% higher than in people of European (white) ancestry for the same BMI [22, 23]. In Viet Nam, percentage body fat may be a better way to identify people at increased metabolic risk. Percentage body fat > 30 in men and > 40 in women detected around 15% of adults as obese, compared to 1.1% in men and 1.3% in women using a BMI threshold of > 30 kg/m2 [24]. Our findings suggest that the 30 kg/m2 threshold used outside pregnancy, or the 32 kg/m2 suggested for use in pregnancy (as per HAPO), are not sensitive indicators of pregnancy risk in this population. Given that the measurement of body fat percentage is challenging during pregnancy, we feel the lower BMI threshold is a practical alternative. This study observed that GDM mothers were at 16% increased odds for delivering LGA babies, with the association modulated by maternal obesity. Therefore, identifying the women at greatest risk of complications could help target nutritional support and intensive blood glucose monitoring in a resource constrained setting.

Our work adds to a growing body of work on GDM in Viet Nam and the association with adverse perinatal outcomes (Fig. 4). Two other studies also based in urban populations reported similar findings with GDM [10, 12], although neither stratified for obesity. Associations between GDM and LGA and preterm birth have been consistently demonstrated. However, the association between GDM and C-section is less consistent. It is notable that the background C-section rate in urban Viet Nam is very high, potentially masking any effect of the GDM on likelihood of C-section birth.

Fig. 4
figure 4

Comparison of studies examining outcomes in pregnancies affected by GDm in Viet Nam

The strengths of this study include a relatively large sample size, which enabled sufficient power to test for GDM’s association with primary C-section, LGA, and preterm birth. This study was conducted using a prospective design with very low loss-to-follow-up (0.2%), minimising selection bias. GDM and BMI were measured objectively, before and without knowledge of the outcomes, reducing information bias. In addition, we used international definitions of GDM (WHO/IADPSG) and size at birth (INTERGROWTH-21st ), enabling comparison with other studies. Pregnancy dating by early-pregnancy ultrasound enabled accurate estimation of risk of preterm birth and calculation of birthweight for gestational age.

We acknowledge this study has some limitations. We were unable to account for differences in individual test results of the OGTT or subsequent blood glucose monitoring and management during pregnancy. Data were also not available for neonatal hypoglycemia, an important outcome. As this was a hospital-based study, we cannot extrapolate the prevalence of GDM to the population, although the rate observed is in keeping with that from other studies in Viet Nam. Long-term effects on the mother and baby were not collected. We were not able to compare our results with previously published obesity risk definitions, as the number of women with BMI > 32 kg/m2 in this study was very low (n = 20). Whilst ideally we would have liked to compare pre-pregnancy BMI, this data was largely based on maternal recall. Since we had objective measures from recruitment (early second trimester) we chose to define BMI at this point. Our results should therefore be interpreted with caution particularly when comparing to studies where BMI was measured pre-pregnancy. While women could change BMI category between conception and 19–22 weeks, we believe that the key message of this paper that those who are obese women, and particularly obese women with GDM, are at highest risk for adverse outcomes remains valid. The relatively high reported rate of previous neonatal death (5-8.7%) was also based on maternal self-report, thus we cannot verify if there was misclassification with other forms of loss (miscarriage, stillbirth, later child death).


Our findings support that BMI > 27.5 kg/m2measured between 19 and 22 weeks gestation can be used to risk-stratify women with GDM. The study was conducted in a resource limited setting, and thus identifying the highest risk group (i.e. women who are obese with GDM) is important for clinical prioritization. For example, obese women with GDM could be recommended more intense antenatal surveillance, earlier GDM screening, or daily blood glucose monitoring.

To our knowledge, our study is the first to specifically study the individual and synergistic effects of GDM and obesity in an Asian population using an Asian specific BMI threshold for obesity. This is important for those caring for women with GDM in SEA countries, as well as those caring for expatriates living abroad. While there may be physiological and metabolic heterogeneity among Asian populations, it is an important step to quantify perinatal risks with parameters relevant to an Asian population, as recommended by an WHO expert panel. As such, we believe our study’s implications could extend beyond women of Vietnamese ethnicity.

Before pregnancy, BMI is a potentially modifiable factor, hence public health and preventative medicine should be directed at helping women maintain their weight in the healthy range. During pregnancy, BMI risk stratification could be used to target more intensive glucose monitoring or dietary support. GDM is a complex condition, and not all women with GDM are at the same risk of adverse outcomes. Evidence is needed to understand the phenotypes of GDM in different populations. We need to move towards offering personalised care approaches in pregnancy that can also optimise the life-long health of women and their children.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.



Australian Carbohydrate Intolerance Study in Pregnant Women


Body Mass Index


Confidence Intervals


Caesarean section


Gestational Diabetes Mellitus


Gross Domestic Product


Hyperglycaemia and Adverse Pregnancy Outcome


Hypertensive Disorders of Pregnancy


Haemolysis, Elevated Liver Enzymes, and Low Platelets


International Association of Diabetes in Pregnancy Study Groups


Large for Gestational Age


Neonatal Intensive Care Unit


Oral Glucose Tolerance Test


Odds Ratio


Preterm Birth Biomarkers


Standard Deviation


South East Asia/n


Small for Gestational Age


World Health Organisation


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Dr. Hirst (the corresponding author) is supported by UKRI Future Leaders’ Fellowship. In addition, the PBB was generously supported by the Bill and Melinda Gates Foundation. The funders had no role in the writing or interpretation of this study.

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SY planned and conducted statistical analyses, interpreted the patient data, and was the major writer of the manuscript. JEH conceptualised the project, supervised the planning, analysis, and manuscript write-up. VTKT, LPD, BTHN, EK acquired the data, and VTKT, EK, DTT, LQT and JEH participated in critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.

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Correspondence to Jane E Hirst.

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This study was conducted in accordance with the Declaration of Helsinki, and granted ethical approval by the Oxford Tropical Research Ethics Committee (OxTREC reference: 28 − 16) and the Tu Du local ethics committee. Informed consent was obtained from all participants for use of data for research purposes. For women who could not read, the participant information sheet and consent form were read to them and a witness was present throughout the entire informed consent process to attest that all questions from the participant were answered and the participant has agreed to take part in the research.

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The authors declare that they have no competing interests.

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Yue, S., Thi, V.T.K., Dung, L.P. et al. Clinical consequences of gestational diabetes mellitus and maternal obesity as defined by asian BMI thresholds in Viet Nam: a prospective, hospital-based, cohort study. BMC Pregnancy Childbirth 22, 195 (2022).

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  • Asian BMI threshold
  • Gestational diabetes mellitus
  • Large for gestational age
  • Maternal obesity
  • Perinatal outcomes
  • Preterm birth
  • Primary C-section
  • South East Asian