Skip to main content

Antepartum urinary tract infection and postpartum depression in Taiwan – a nationwide population-based study



Urinary tract infections (UTIs) are among the most common bacterial infections in pregnant women due to anatomic and physiologic changes in the female urinary tract during pregnancy, and antepartum UTIs can cause adverse pregnancy outcomes that may induce mental stress. There have only been a few studies, however, investigating antepartum UTIs and mental stress. As such, the present study was conducted in order to investigate the association between antepartum UTIs and postpartum depression (PPD).


We used data from the 2000–2013 National Health Insurance Research Database (NHIRD) of Taiwan. Data regarding a total of 55,087 singleton pregnancies was utilized, including data regarding 406 women who were newly diagnosed with PPD in the first 6 months postpartum. The associations between PPD and antepartum UTIs or other risk factors were examined by multiple logistic regression analysis.


The logistic regression analysis results indicated that PPD was associated with antepartum UTIs (adjusted odds ratio [aOR] 1.27; 95% confidence interval [CI] (1.07–1.65). Furthermore, the risk of PPD was higher in women with an upper antepartum UTI (aOR 2.97 (1.31, 6.77) than in those with a lower antepartum UTI (aOR 1.21 (1.02, 1.58)).


Antepartum UTIs, particularly upper antepartum UTIs, are significantly associated with PPD. This information may encourage physicians to pay greater attention to the mental health of women who have suffered upper UTIs during their pregnancies.

Peer Review reports


Previous epidemiological studies have reported that postpartum depression (PPD) occurs in approximately 10–15% of women after delivery [1,2,3]. PPD is defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) [4] as a major depressive episode occurring during pregnancy or in the 4 weeks following delivery. However, PPD usually occurs in the first 6 months after delivery [5, 6]. A recent study of postnatal women in the UK and Taiwan showed that 19% of Taiwanese women and 18% of British women reported experiencing PPD [7].

During pregnancy, women experience substantial physiological and psychological changes. These changes may lead postpartum depressive mood. Previous studies have highlighted numerous risk factors associated with PPD including physical, psychological, obstetric, pediatric, socio-demographic, and cultural factors [8, 9].

Pregnancy also causes anatomic and physiologic changes to the female urinary tract. Urinary tract infections (UTIs) are among the most common bacterial infections during pregnancy [10], with approximately 2–10% of pregnant women experiencing a UTI [11]. Antepartum UTIs are associated with some adverse pregnancy outcomes [12] and are also one of the major causes of antepartum admissions [13].

To the best of our knowledge, however, there have been very few reports on the relationship, if any, between antepartum UTIs and PPD. As such, the present population-based study sought to (1) determine whether there is a relationship between antepartum UTIs and PPD and (2) determine whether different locations of antepartum UTIs (that is, in the upper or lower urinary tract) result in different effects on the mental health of pregnant women.


Data source and collection

We used the National Health Insurance Research Database (NHIRD) for this population-based study. The NHIRD is a database collected by the National Health Insurance (NHI) program of Taiwan, which is a unique health insurance system covering almost all the citizens of Taiwan. The NHI program was begun in 1995 and provided coverage for 99.9% of the 23 million people in Taiwan as of 2013 [14]. The NHIRD is a large-scale database that contains outpatient and inpatient medical information about the patients included in the database, including information on their medication use, surgical procedures, intervention procedures, and clinical prescriptions [15, 16]. At present, there are more than 2000 published studies that have utilized data included in this database [17]. The present retrospective population-based study used a sub-dataset of the NHIRD called the Longitudinal Health Insurance Database 2000 (LHID 2000) that included data from January 2000 to December 2013. The LHID 2000 contains 1 million people who were randomly selected from the total of 23 million residents included in the NHIRD in 2000 [18, 19]. The disease diagnoses of the people included in the database were made according to the International Classification of Diseases, 9th revision, Clinical Modification (ICD-9-CM).

Study population

The study population was selected from the LHID 2000 covering the period from January 2000 to December 2013. The selection of participants in this study is shown in Fig. 1. There were 73,829 singleton pregnancies among the database cohort during the study period. The exclusion criteria were as follows (1) women with delivery before Dec 31st 2000 or after July 31st 2013 (n = 11,480); (2) women who were younger than 20 years old (n = 2571); (3) women who had a previous history of major depressive disorder (n = 2449); and (4) women with a follow-up period of less than 6 months (n = 55). In Taiwanese civil law, people in their twenty years of age are adult. We chose adult women in our study with approval by the Institutional Review Board. We selected women identified as having PPD according to a medical record of a PPD diagnosis made by a psychiatrist and by the use of antidepressants in the first 6 months after delivery (ICD-9-CM: 309, 311, 296.2, 296.3, 296.5, 300.4).

Fig. 1
figure 1

Flowchart of the collection of subjects from the Longitudinal Health Insurance Database2000 (LHID2000), a sub-dataset of National Health Insurance Research Database (NHIRD), from January 2000 to December 2013

Each UTI was diagnosed by collecting a clean-voided, midstream urine sample for urinalysis and urine culture. A positive urine culture was defined by the isolation of at least one single microorganism with > 10,000 colonies/mL. An upper UTI was diagnosed according to physical examination, urinalysis, and urine culture results, with positive physical examination findings including flank pain, fever, chills, anorexia, nausea, and vomiting. The diagnosis of a lower UTI was also made via physical examination, urinalysis, and urine culture results, with the typical manifestations of a lower UTI including dysuria, frequency, urgency, and suprapubic pain.


Variables were selected based on clinical manifestations or complications during pregnancy. We retrospectively investigated different variables in women with or without PPD. In this study, antepartum UTIs were grouped into two categories: upper and lower UTIs. An upper UTI consists of an infection of the renal parenchyma and pelvicaliceal system. This includes cases of pyelonephritis, pyelitis, and perirenal infection or abscess (ICD-9-CM: 590.1, 590.2, 590.8, 590.9). Lower UTI infections are located in the lower urinary tract and include cystitis and urethritis (ICD-9-CM: 595.0, 595.1, 595.2, 595.3, 595.4, 595.8, 595.9, 597.8, 599.0). Additional factors of antepartum, peripartum, and postpartum complications that are related to PPD, according to a previous study [20], were also analyzed, including antepartum hemorrhage (ICD-9-CM: 641.8, 641.9), eclampsia or pre-eclampsia (ICD-9-CM: 642.4, 642.5, 642.6), premature separation of placenta (ICD-9-CM: 641.2), placenta previa (ICD-9-CM: 641.0, 641.1), oligohydramnios (ICD-9-CM: 658), polyhydramnios (ICD-9-CM: 657), poor fetal growth (ICD-9-CM: 656.5), excessive fetal growth (ICD-9-CM: 656.6), cervical incompetence (ICD-9-CM: 654.5), premature birth (ICD-9-CM: 644), chronic pulmonary disease (ICD-9-CM: 490–492, 494,496), hypertension (ICD-9-CM: 401.1401.9), hypertension-complicated pregnancy (ICD-9-CM: 642.0, 642.1, 642.2, 642.3, 642.9), diabetes complicating pregnancy childbirth (ICD-9-CM: 648.0), hyperlipidemia (ICD-9-CM: 272.4), heart disease (ICD-9-CM: 393–398, 402, 404.0, 404.1, 404.9, 410–414, 415.0, 416.1, 416.8, 416.9, 420–429), anemia (ICD-9- CM: 280–285), cerebrovascular disease (ICD-9-CM: 430–438), Parkinson disease (ICD-9-CM: 332), epilepsy (ICD-9-CM: 345), tuberculosis (ICD-9-CM: 011,012), asthma (ICD-9-CM: 493), chronic kidney disease (ICD-9-CM: 585,586,588). The monthly incomes of the study population, as per insurance information, were divided into four groups: < 20,000, 20,000–40,000, 40,000–60,000, and ≥60,000 new Taiwan dollars [21].

Statistical analysis

We used the Microsoft® SQL Server® 2008 to calculate and manage the patients’ baseline data. The IBM SPSS statistics software v20 (IBM SPSS, 2013) was used for further data analysis. All the variables were calculated as percentages. Standard deviations and mean values were determined for the quantitative variables. Statistical significance was determined using Student’s T test and the Chi-square test. Multivariate logistic regression analysis was used to determine any associations between antepartum UTIs, PPD, and additional factors. We selected risk factors into further multivariate logistic regression analysis by which total n5 in the PPD group. A two-sided p-value < 0.05 was regarded as statistically significant in all statistical tests.



Data for a total of 55,087 women who had singleton pregnancies between January 2001 and June 2013 was utilized in this study, including data for a total of 406 women who were newly diagnosed with PPD in the first 6 months postpartum. All the singleton pregnancy women were divided into two groups: a PPD group (n = 406) and a non-PPD group (n = 54,691). Table 1 shows the demographic characteristics of the two study groups. Women with PPD had older ages (31.9 ± 10.4 years, p < 0.001) compared with the non-PPD group. There were many antepartum comorbidities that were found to be significantly associated with PPD, including chronic pulmonary disease, hypertension, peptic ulcer disease, chronic kidney disease, liver cirrhosis, hypertension-complicated pregnancy, heart disease, asthma, epilepsy, early delivery onset, premature birth, and UTI. Both upper and lower tract UTIs showed significant associations with PPD. The average hospital stay of all the women for childbirth was 4.8 ± 2.2 days. The average time to PPD diagnosis was 88.0 ± 51.0 days after delivery.

Table 1 Demographic characteristics of study populations in Taiwan from 2000 to 2013

Multivariable logistic regression analysis of postpartum depression

Table 2 shows the logistic regression analysis results for certain risk factors of PPD. A monthly income of less than NT$ 20,000 and aged 20–24 were used as the reference. Heart disease (aOR 1.95 (1.26, 3.02), p < 0.001), antepartum UTI (aOR 1.27 (1.07, 1.65), p < 0.05), and age40 (aOR 1.98 (1.20, 3.29), p < 0.01) were all significant risk factors of PPD.

Table 2 The association between PPD and certain risk factors (in which total n5 in the PPD group) analyzed by multivariate logistic regression model

Among all antepartum UTIs, upper tract UTIs (aOR 2.97 (1.31,6.77)) had a higher OR than lower tract UTIs (aOR 1.21 (1.02, 1.58)). In addition, the aOR of monthly income NT$40,000–60,000 was 0.59 ((0.36, 0.97), p < 0.05).


This is the first study that has focused on the relationship between antepartum UTIs and PPD. The results of this 14-year population based study show that antepartum UTIs are significantly associated with PPD. In addition, women with upper antepartum UTIs had near 3-fold greater risk of PPD than normal groups (aOR 2.97(1.31, 6.77)).

According to the study results, chronic kidney disease, epilepsy, heart disease, and upper UTI are the four greatest risk factors for PPD. These findings are consistent with those of previous studies that have also found that chronic kidney disease, epilepsy, and heart disease are associated with major depressive disorder or PPD [22,23,24,25,26,27,28]. In fact, the relationship between chronic kidney disease and major depressive disorder is well documented [22,23,24], with the decreased quality of life caused by chronic kidney disease having been found to affect mental health in both men and women [24]. Similarly, the relationship between epilepsy and higher rates of PPD is well documented [25,26,27]. Meanwhile, a prospective study revealed that the rate of neonatal complications is significantly higher in women with heart disease [28]. Therefore, it is reasonable that PPD is related to antepartum heart disease.

UTIs are among the most common bacterial infections in women, affecting approximately 10% of women. A previous study showed that 2–10% of pregnant women had suffered from a UTI [8], while another study found that 10% of all antepartum admissions were due to UTIs [29]. The higher UTI rate is caused by anatomical and physiological changes to the urinary tract system due to pregnancy [30]. Furthermore, pregnancy also causes asymptomatic bacteriuria changes to symptomatic UTI and reinfection [31].

The symptoms accompanying a UTI include urinary frequency and urgency, painful urination, and lower abdomen discomfort. Overactive bladder syndrome shares some of the same symptoms as UTIs, including urinary frequency and urgency, as well as urgency incontinence. In non-pregnant women, an association between overactive bladder syndrome and major depressive disorder has previously been reported [32,33,34,35,36]. Relatedly, van de Pol et al. demonstrated a significant relationship between PPD and overactive bladder syndrome [37]. Pregnant women who experience urinary frequency and urgency due to a UTI or overactive bladder syndrome may be embarrassed to talk about these symptoms with their physicians, which may further increase the mental stress experienced by these women. Abdollahi et al. demonstrated that recurrent UTIs are associated with PPD, but they did not further examine the relationship with respect to upper and lower UTIs [38].

Antepartum UTIs and PPD have several common risk factors such as obstetric, pediatric, and socioeconomic factors. Mazor-Dray et al. demonstrated that maternal UTIs are associated with preterm delivery, preeclampsia, intra-uterine growth restriction, and cesarean delivery [12]. Furthermore, the rates of PPD have been found to be as high as 40% among women with premature delivery [39], while Yang et al. demonstrated that cesarean delivery, preterm delivery, and preeclampsia were associated with the development of PPD [21]. That being said, preeclampsia was not shown to be associated with PPD in our study. Otherwise, women of low socioeconomic status have a five-fold greater incidence of bacteriuria than normal populations. Low socioeconomic status has also been found to be a risk factor for both antepartum UTIs [40, 41] and PPD [42, 43], while antepartum UTIs are an independent risk factor of PPD.

In our study, upper antepartum UTIs had a higher aOR (OR 2.97 (1.31,6.77)) than lower UTIs. Upper antepartum UTIs are more common during the second half of pregnancy [44], are the most common severe complication of pregnancy [28], and cause approximately 12% of pregnancy associated sepsis complications that result in admission to an obstetric intensive care unit [45]. Approximately 20% of upper UTIs in pregnant women will lead to sepsis and multiple-system failure from endotoxemia [44, 46]. Upper antepartum UTIs reduce physical strength and increase mental stress in pregnant women. In addition, upper antepartum UTIs has 2.97-fold risk of preterm delivery [47], which is another important risk factor of PPD [21].

This study was a retrospective population-based study. Some data that can be useful in determining the severity of a UTI, such as the bacterial species involved, laboratory findings, asymptomatic bacteriuria status, and the side of pyelonephritis, were not available in the NHIRD. In addition, the number of upper and lower antepartum UTI patients in the study was relatively limited. Moreover, we collected PPD patients by coding ICD-9-CM coded which were diagnosed by psychiatrists who have individual concerns about PPD diagnosis. The incidence of PPD in the study cohort may have been underestimated as some women who experience depression after delivery do not seek medical help. Large-scale, prospective studies are needed to further evaluate the association between antepartum UTIs and PPD.


The results of this study demonstrate that antepartum UTIs, particularly upper antepartum UTIs, are significantly associated with PPD. Specifically, women with upper antepartum UTIs had 2.97-fold increased risk of PPD. As UTIs are among the most common bacterial infections in pregnant women, our results provide useful information for gynecologists, obstetricians, and health policy planners. Above all, they indicate that these health care professionals should pay greater attention to the mental health of mothers who have suffered upper UTIs during their pregnancies.



Charlson comorbidity index


International classification of diseases, 9th revision, clinical modification

LHID 2000:

Longitudinal health insurance database 2000


National health insurance research database


Odds ratio


Postpartum depression


Urinary tract infection


  1. O'Hara MW, Schlechte JA, Lewis DA, Varner MW. Controlled prospective study of postpartum mood disorders: psychological, environmental, and hormonal variables. J Abnorm Psychol. 1991;100(1):63.

    Article  PubMed  Google Scholar 

  2. Stowe ZN, Nemeroff CB. 1995. Women at risk for postpartum-onset major depression. Am J Obstet Gynecol. 1995;173(2):639–45.

    Article  CAS  PubMed  Google Scholar 

  3. Lee DT, Yip AS, Chiu HF, Leung TY, Chung TK. A psychiatric epidemiological study of postpartum Chinese women. Am J Psychiatry. 2001;158(2):220–6.

    Article  CAS  PubMed  Google Scholar 

  4. APA. Diagnostic and statistical manual of mental disorders DSM-V. Washington, DC: American Psychiatric Association; 2013.

    Google Scholar 

  5. O'Hara MW A, McCabe JE. Postpartum depression: current status and future directions. Annu Rev Clin Psychol. 2013;9:379–407.

    Article  PubMed  Google Scholar 

  6. Chang FW, Lee WY, Liu YP, Yang JJ, Chen SP, Cheng KC, Lin YC, Ho TW, Chiu FH, Hsu RJ, et al. The relationship between economic conditions and postpartum depression in Taiwan: a nationwide population-based study. J Affect Disord. 2016;204:174–9.

    Article  PubMed  Google Scholar 

  7. Huang YC, Mathers N. Postnatal depression -- biological or cultural? A comparative study of postnatal women in the UK and Taiwan. J Adv Nurs. 2008;33:279–87.

    Article  Google Scholar 

  8. Robertson E, Grace S, Wallington T, Stewart DE. Antenatal risk factors for postpartum depression: a synthesis of recent literature. Gen Hosp Psychiatry. 2004;26(4):289–95.

    Article  PubMed  Google Scholar 

  9. Norhayati MN, Hazlina NN, Asrenee AR, Emilin WW. Magnitude and risk factors for postpartum symptoms: a literature review. J Affect Disord. 2015;175:34–52.

    Article  CAS  PubMed  Google Scholar 

  10. Le J, Briggs GG, McKeown A, Bustillo G. Urinary tract infections during pregnancy. Ann Pharmacother. 2004;38(10):1692–701.

    Article  PubMed  Google Scholar 

  11. Lee M, Bozzo P, Einarson A, Koren G. Urinary tract infections in pregnancy. Can Fam Physician. 2008;54:853–4.

    PubMed  PubMed Central  Google Scholar 

  12. Mazor-Dray E, Levy A, Schlaeffer F, Sheiner E. Maternal urinary tract infection: is it independently associated with adverse pregnancy outcome? J Matern Fetal Neonatal Med. 2009;22(2):124–8.

    Article  PubMed  Google Scholar 

  13. Sheffield JS, Cunningham FG. Urinary tract infection in women. Obstet Gynecol. 2005;106(5):1085–92.

    Article  PubMed  Google Scholar 

  14. Chen JY, Liu JM, Chang FW, Chang H, Cheng KC, Yeh CL, Wei YF, Hsu RJ. Scabies increased the risk and severity of COPD: a nationwide population-based study. Int J Chron Obstruct Pulmon Dis. 2016;11:2171–8.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Liu JM, Lin PH, Hsu RJ, Chang YH, Cheng KC, Pang ST, Lin SK. Complementary traditional Chinese medicine therapy improves survival in patients with metastatic prostate cancer. Medicine. 2016;95(31):e4475.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Liu JM, Wang HW, Chang FW, Liu YP, Chiu FH, Lin YC, Cheng KC, Hsu RJ. The effects of climate factors on scabies. A 14-year population-based study in Taiwan. Parasite. 2016;23:54.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Hsing AW, Ioannidis JP. Nationwide population science: lessons from the Taiwan National Health Insurance Research Database. JAMA Intern Med. 2015;175(9):1527–9.

    Article  PubMed  Google Scholar 

  18. National Health Insurance Institutes: National Health Insurance Research Database. Accessed 10 Oct 2016.

  19. Liu JM, Chiu FH, Lin CY, Chang FW, Hsu RJ. Incidence of autoimmune diseases in patients with scabies: a nationwide population-based study in Taiwan. Rheumatol Int. 2017;37(7):1125–34.

    Article  PubMed  Google Scholar 

  20. Yang SN, Shen LJ, Ping T, Wang YC, Chien CW. The delivery mode and seasonal variation are associated with the development of postpartum depression. J Affect Disord. 2011;132(1):158–64.

    Article  PubMed  Google Scholar 

  21. Lin CY, Chang FW, Yang JJ, Chang CH, Yeh CL, et al. Increased risk of bipolar disorder in patients with scabies: a nationwide population-based matched-cohort study. Psychiatry Res. 2017;257:14–20.

    Article  PubMed  Google Scholar 

  22. Hedayati SS, Minhajuddin AT, Afshar M, Toto RD, Trivedi MH, Rush AJ. Association between major depressive episodes in patients with chronic kidney disease and initiation of dialysis, hospitalization, or death. JAMA. 2010;303(19):1946–53.

    Article  CAS  PubMed  Google Scholar 

  23. Zalai D, Szeifert L, Novak M. Psychological distress and depression in patients with chronic kidney disease. Semin Dial. 2012;25(4):428–38.

    Article  PubMed  Google Scholar 

  24. Abdel-Kader K, Unruh ML, Weisbord SD. Symptom burden, depression, and quality of life in chronic and end-stage kidney disease. Clin J Am Soc Nephrol. 2009;4(6):1057–64.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Turner K, Piazzini A, Franza A, Fumarola C, Chifari R, Marconi AM, et al. Postpartum depression in women with epilepsy versus women without epilepsy. Epilepsy Behav. 2006;9(2):293–7.

    Article  PubMed  Google Scholar 

  26. Galanti M, Newport DJ, Pennell PB, Titchner D, Newman M, Knight BT, et al. Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective study. Epilepsy Behav. 2009;16(3):426–30.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Turner K, Piazzini A, Franza A, Marconi AM, Canger R, Canevini MP. Epilepsy and postpartum depression. Epilepsia. 2009;50(Suppl 1):24–7.

    Article  PubMed  Google Scholar 

  28. Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, et al. Cardiac disease in pregnancy (CARPREG) investigators. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001;104(5):515–21.

    Article  CAS  PubMed  Google Scholar 

  29. Bacak SJ, Callaghan WM, Dietz PM, Crouse C. Pregnancy-associated hospitalizations in the United States, 1999–2000. Am J Obstet Gynecol. 2005;192(2):592–7.

    Article  PubMed  Google Scholar 

  30. Nowicki B. Urinary tract infection in pregnant women: old dogmas and current concepts regarding pathogenesis. Curr Infect Dis Rep. 2002;4:529–35.

    Article  PubMed  Google Scholar 

  31. Foxman B, Brown P. Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs. Infect Dis Clin N Am. 2003;17:227–41.

    Article  Google Scholar 

  32. Zorn BH, Montgomery H, Pieper K, Gray M, Steers WD. Urinary incontinence and depression. J Urol. 1999;162:82–4.

    Article  CAS  PubMed  Google Scholar 

  33. Buchsbaum GM, Chin M, Glantz C, Guzick D. Prevalence of urinary incontinence and associated risk factors in a cohort of nuns. Obstet Gynecol. 2002;100:226–9.

    PubMed  Google Scholar 

  34. Chiverton PA, Wells TJ, Brink CA, Mayer R. Psychological factors associated with urinary incontinence. Clin Nurse Spec. 1996;10:229–33.

    Article  CAS  PubMed  Google Scholar 

  35. Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20:327–36.

    CAS  PubMed  Google Scholar 

  36. Melville JL, Delaney K, Newton K, Katon W. Incontinence severity and major depression in incontinent women. Obstet Gynecol. 2005;106:585–92.

    Article  PubMed  Google Scholar 

  37. van de Pol G, van Brummen HJ, Bruinse HW, Heintz AP, van der Vaart CH. Is there an association between depressive and urinary symptoms during and after pregnancy? Int Urogynecol J Pelvic Floor Dysfunct. 2007;18(12):1409–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Abdollahi F, Zarghami M, Azhar MZ, Sazlina SG, Lye MS. Predictors and incidence of post-partum depression: a longitudinal cohort study. J Obstet Gynaecol Res. 2014;40(12):2191–200.

    Article  PubMed  Google Scholar 

  39. Vigod SN, Villegas L, Dennis CL, Ross LE. Prevalence and risk factors for postpartum depression among women with preterm and low-birth-weight infants: a systematic review. BJOG. 2010;117(5):540–50.

    Article  CAS  PubMed  Google Scholar 

  40. Turck M, Goffe BS, Petersdorf RG. Bacteriuria of pregnancy. Relation to socioeconomic factors. N Engl J Med. 1962;266:857–60.

    Article  CAS  PubMed  Google Scholar 

  41. Golan A, Wexler S, Amit A, Gordon D, David MP. Asymptomatic bacteriuria in normal and high-risk pregnancy. Eur J Obstet Gynecol Reprod Biol. 1989;33:101–8.

    Article  CAS  PubMed  Google Scholar 

  42. Inandi T, Bugdayci R, Dundar P, Sumer H, Sasmaz T. Risk factors for depression in the first postnatal year: a Turkish study. Soc Psychiatry Psychiatr Epidemiol. 2005;40:725–30.

    Article  PubMed  Google Scholar 

  43. Ozdemir H, Ergin N, Selimoglu K, Bilgel N. Postnatal depressive mood in Turkish women. Psychol Health Med. 2014;10:96–107.

    Article  Google Scholar 

  44. Hill JB, Sheffield JS, McIntire DD, Wendel GD Jr. Acute pyelonephritis in pregnancy. Obstet Gynecol. 2005;105:18–23.

    Article  PubMed  Google Scholar 

  45. Zeeman GG, Wendel GD, Cunningham FG. A blueprint for obstetric critical care. Am J Obstet Gynecol. 2003;188(2):532–6.

    Article  PubMed  Google Scholar 

  46. Cunningham FG, Morris GB, Mickal A. Acute pyelonephritis of pregnancy: a clinical review. Obstet Gynecol. 1973;42(1):112–7.

    CAS  PubMed  Google Scholar 

  47. Farkash E, Weintraub AY, Sergienko R, Wiznitzer A, Zlotnik A, Sheiner E. Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and outcomes. Eur J Obstet Gynecol Reprod Biol. 2012;162(1):24–7.

    Article  PubMed  Google Scholar 

Download references


The implications and conclusions of this study do not represent the opinions of the Bureau of National Health Insurance, the Department of Health, or the National Health Research Institute.


This work was supported by grants from the Ministry of Science and Technology Taiwan (MOST 104–2320-B-016 -012 -MY3), the Tri-Service General Hospital of Taipei, Taiwan (TSGH-106-148 and TSGH-107-104-2320B-016-012-MY3), the grants from the Taoyuan General Hospital, Ministry of Health and Welfare (PYT10702), and the Teh-Tzer Study Group for Human Medical Research Foundation (A1061082). The funders had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.

Availability of data and materials

We are unable to share our data, as the National Health Insurance program of Taiwan limits access to the National Health Insurance Research Database only to approved applicants.

Author information

Authors and Affiliations



JML wrote the proposal and prepared the manuscript. YPL contributed the conception and design of the manuscript. FWC revised the manuscript. SPC conducted the data analysis. HHC and SPC collected the data and helped prepare the manuscript. RJH prepared the manuscript and data analysis. JJY revised the manuscript. RJH revised the manuscript and data analysis. All the authors read and approved the final manuscript.

Corresponding authors

Correspondence to Fung-Wei Chang or Ren-Jun Hsu.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Institutional Review Board of the Tri-Service General Hospital (approval No: B-104-20, Taipei, Taiwan).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, JM., Chiu, FH., Liu, YP. et al. Antepartum urinary tract infection and postpartum depression in Taiwan – a nationwide population-based study. BMC Pregnancy Childbirth 18, 79 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: