Skip to main content

Induction of twin pregnancy and the risk of caesarean delivery: a cohort study



Complications are common in twin pregnancies and induction of labour is often indicated. Most methods for induction are used but data on risks related to induction methods are sparse. The aim of this study was to investigate the association between induction of labour and caesarean delivery in twin pregnancies, and to assess the influence of induction method.


Cohort study of twin pregnancies ≥ 34 weeks, planned for vaginal delivery, from two University Hospitals in Sweden. Data were collected from medical records during the periods 1994 (Örebro) and 2004 (Uppsala) to 2013. During the study period there were 78,180 live born births and 1,282 were twin births. Women with previous caesarean section were excluded. Induction methods were categorized into amniotomy, oxytocin and cervical ripening (intra cervical Foley catheter or prostaglandin). Adjusted odds ratios (AOR) with 95 % confidence interval (CI) for caesarean section were calculated by logistic regression and were adjusted for parity, maternal age, gestational length, complications to the pregnancy, infant birth weight and year of birth. Spontaneous labour onsets were used as the reference group. The main outcome measure was caesarean section.


In 462 twin pregnancies, 220 (48 %) had induction of labour and 242 (52 %) a spontaneous labour onset. Amniotomy was performed in 149 (68 %) of these inductions, oxytocin was administered in 11 (5 %) and cervical ripening was used in 60 (27 %). The rate of caesarean sections was 21 % in induced and 12 % in spontaneous labours (p 0.01). The absolute risk of caesarean section following induction was: 15 % with amniotomy; 36 % with oxytocin and 37 % with Foley/prostaglandin. Induction of labour increased the risk of caesarean section by 90 % compared with spontaneous labour onset (AOR 1.9, 95 % CI 1.1-3.5) and, when cervical ripening was used, the risk increased more than two fold (AOR 2.5, 95 % CI 1.2-5.3).


Induction of labour in twin pregnancies increases the risk of caesarean section compared with spontaneous labour onset, especially if Foley catheter or prostaglandins are required. However, approximately 80 % of induced labours are delivered vaginally.

Peer Review reports


Numerous methods for induction of labour have been used in twin pregnancies, but data on safety and efficacy are limited. Published studies of this subject are few in number and small in size and, to date, results and experiences from labour induction of singletons are extrapolated to twins. Standards established for single gestations may not be applicable to twin gestations, since the circumstances for labour and delivery differ. For example, the progress of active phase labour is slower with twins for both nulli-and multiparous women [1] and slower labours in twins may be the result of uterine inertia due to an overdistended uterus and/or malpresentations [2].

Compared with singletons, twin pregnancies are associated with increased risks of complications such as gestational diabetes [3], gestational hypertension [4, 5], preeclampsia [6, 7], and intra hepatic cholestasis [8]. There is also an increased risk of stillbirth with advancing gestational age in otherwise uncomplicated twin pregnancies, which is why elective birth is recommended at 37–38 weeks gestation [9]. Thus, complications to twin pregnancies are frequently seen and labour induction is often indicated.

The potential advantages of induction of labour have to be balanced against any associated adverse consequences, such as an increased risk of caesarean delivery. The risk of caesarean section with induction of labour is, in part, a function of cervical ripeness, in that a higher rate of caesareans has been observed in women with lower Bishop scores compared to women with higher Bishop scores [10, 11]. With an unripe cervix, ways of promoting cervical ripening are needed and, in twin pregnancies, Foley catheters and various forms of prostaglandins are used [2].

For twin births, there is a limited amount of data about the risk of caesarean section by induction method. In previous observational studies, that included at the most 134 twin pregnancies, oxytocin, vaginal misoprostol and Foley catheters were used for induction and no difference in caesarean section rate was found when compared to singletons [12], oxytocin only [13] or expectant management [14]. It appears that previous studies dealing with induction of twin pregnancies are underpowered to address outcomes such as caesarean section. There are no studies with a sample size large enough to separate inductions that require cervical ripening agents from those allowing amniotomy, when estimating risk of caesarean section.

The aim of this study was to investigate the association between induction of labour and caesarean section through comparison of induction with spontaneous labour onset in twin pregnancies. A further aim was to analyse to what extent the association was influenced by method of induction.


This is a cohort study on twin pregnancies at gestational age ≥34 weeks from two university hospitals in Sweden. All twin pregnancies were retrieved from a local database of both departments for the years 2004–2013 in Uppsala and 1994-2013 in Örebro. During the study period there were 78,180 live born births and the study cohort included 1,282 twin births (Uppsala: n 577; Örebro: n 705). Fig. 1 illustrates the flowchart of the study population. The regional Ethics Committee at Uppsala University approved the study and informed written consent was obtained from participants.

Fig. 1
figure 1

Flow chart of the study population

During the study period there was an increase in the total caesarean section rate at both units (12 % to 17 %) and the overall induction rate increased from 8 % in 1994 to 15 % in 2013. The caesarean section rate in twin deliveries increased by 10 %, and was 55 % in 2013.

Three hundred and seventy four women did not give informed consent, leaving 57 % of eligible cases to be included in the study. Twin gestations with caesarean section performed before labour, and women with a history of previous caesarean section were excluded. Births with a caesarean section of the second twin after vaginal delivery of the first twin were also excluded. The reason for exclusion was that caesarean delivery of the second twin after vaginal birth of the first twin is often performed due to malpresentation or threatened asphyxia, situations, that can occur regardless of how labour proceeded until delivery of the first twin. After exclusions, there were 462 women with twin pregnancies that formed the study cohort (Fig. 1).

Demographic information and characteristics of pregnancy, labour, delivery and neonatal data were retrieved by manual review of the medical records. Parity was categorized into nulliparous and parous, and maternal age into < 35 and 35 years or older. Gestational age was based on the estimated delivery date by ultrasound examinations routinely performed in the second trimester (around the 17th week of gestation), when chorionicity was also decided. A second trimester scan is routine in Sweden since the mid-90s and approximately 95 % of pregnant women are scanned. A first trimester scan is not routine in Sweden why chorionicity diagnosis is less accurate in our population. Embryo transfer determined gestational age when pregnancy was achieved by in vitro fertilization. Gestational length was categorized into < 36, 36–38 and >38 weeks. Complications during the pregnancy included gestational hypertension, preeclampsia, gestational diabetes, intrahepatic cholestasis, anaemia, intrauterine growth retardation and oligohydramniosis.

At the departments, cervical ripening, with the use of intracervical Foley catheter or vaginal prostaglandin E2 (dinoprostone), is generally applied if the Bishop score is less than six. From 2013, oral prostaglandin E1 (misoprostol) was used. Once Bishop score of six or more is reached, amniotomy is performed and oxytocin infusion started in most women that required cervical ripening. Amniotomy is performed with a Bishop score of six or more and usually oxytocin is administered within one to two hours. Oxytocin is used for induction of women with premature rupture of the membranes. The units used the same standard protocol for oxytocin. Inductions of labour were categorized into amniotomy, oxytocin or use of cervical ripening agent (Foley catheter or Prostaglandin).

Failed induction was considered the indication when a caesarean section was performed in the latency phase. Duration of labour was calculated from partograms, from onset of the active phase of labour (four cm cervical dilation) to delivery. Long labours were defined as lasting more than 12 hours. A progress of less than one cm cervical dilation per hour during at least four hours in active first stage labour or, a second stage lasting more than three hours, defined abnormal labour.

Birth weight of the neonates was categorized based on the 25th and 75th percentiles of the study population. In Sweden, small for gestational age (SGA) is defined as a birth weight less than-2 standard deviations (SD) from the mean for gestational age and gender. Umbilical artery sampling and blood gas analysis is routine at both departments. The main outcome was caesarean delivery.

Statistical analysis was performed with the SPSS statistical package 20.0 (SPSS Inc., Chicago, IL, USA). Differences between categorical variables were analysed using chi-square test. Differences between continuous variables were tested with the independent sample t test or a Mann–Whitney U test, where appropriate. Risk of caesarean delivery was estimated for births exposed for induction of labour, using spontaneous onset of labour as reference. Odds ratios (OR) are presented with 95 % confidence intervals (CI). The model was adjusted for parity, maternal age, complications to the pregnancy, gestational length in weeks, infant weight in percentiles (as described above), and year of birth categorized into before 2004 and 2004 or later.


Of 462 included twin births, 242 (52 %) had a spontaneous onset of labour and 220 (48 %) were induced. Indications for inductions were: gestational length (>38 weeks) 61 (28 %); preeclampsia 49 (22 %); elective 42 (19 %); intrauterine growth retardation 33 (15 %); intrahepatic cholestasis 11 (5 %); premature rupture of membranes 12 (5.5 %); gestational hypertension 6 (3 %) and others 6 (3 %). Elective inductions comprised women with a wish to end their pregnancy because of physical discomfort and tiredness.

The Bishop score in induced labours was less than six in 30 % of women with a median (interquartile range) of 6 (5–7). Inductions were started by amniotomy in 149 (68 %), oxytocin infusion in 11 (5 %) and Foley catheter/prostaglandin in 60 (27 %).

Maternal characteristics and data on labour and delivery are presented in Table 1. Compared with spontaneous onsets, women with induced labours had more advanced gestational age and more often complications to the pregnancy. Oxytocin was used more often and for a longer time in induced labours but there was no difference in maximum doses. Duration of labour or occurrence of protracted or long labours did not differ. The rate of caesarean sections was higher in induced compared with spontaneous labours, 21 % vs. 12 % respectively (p 0.01). There was no difference in the rate of vacuum deliveries. Forceps deliveries were not found in this cohort.

Table 1 Summary of maternal characteristics and data on labour and delivery according to labour onset

Mean birth weights of the first and second twins were higher in induced pregnancies, but second twins were more often small for gestational age (Table 2). There were no differences in sex, Apgar score less than seven at five minutes or umbilical artery pH values at birth.

Table 2 Neonatal outcome

In labours induced by amniotomy or by Foley/prostaglandins, the latency phase had a median duration of, respectively, 150 (40–225) minutes, and 690 (442–1618) minutes, p < 0.001 (data not shown in Table). A Bishop score < 6 resulted in a caesarean section in 25 (38 %) women compared with 19 (12 %) when the Bishop score ≥ 6 (p < 0.001). Bishop score was missing in three cases (data not shown in table). Compared with spontaneous labour, the risk of caesarean section in induced labours was estimated to an adjusted odds ratio (AOR) of 1.9 with 95 % confidence interval (CI) 1.1 to 3.5 (Table 3). Nulliparity was the strongest risk factor for caesarean section. Gestational length, complications to the pregnancy and infant birth weight were not associated with an increased risk for caesarean section.

Table 3 Unadjusted and adjusted odds ratios (OR) for caesarean section by onset of labour and maternal and infant characteristics

The indications for caesarean delivery in spontaneous labours were: suspected fetal asphyxia 23 (77 %); protracted labour 5 (16 %); one placental abruption and one transverse lie. In induced labours the indications were: suspected fetal asphyxia 26 (55 %); protracted labour 5 (11 %); and failed induction 16 (34 %).

Table 4 depicts the AOR of caesarean section when induced labour onsets were stratified into induction with amniotomy, oxytocin and cervical ripening. Odds ratios were adjusted for maternal age, gestational length, parity, complications to the pregnancy, weight of first twin and second twin and year of birth. Compared with spontaneous labour onsets, labours induced with cervical ripening were associated with a 2.5 times increased risk of caesarean section.

Table 4 Unadjusted and adjusted odds ratios (OR) for caesarean section by induction method


This study suggests that induction of twin pregnancies is associated with a two-fold increase in risk of caesarean section compared with spontaneous labour onset, and that the increase in risk is associated to the need for cervical ripening. Despite the increased risk, the majority had a vaginal delivery. In women where amniotomy was possible, induction of labour had no increased risk of caesarean delivery. Almost half of pregnancies were induced in this study; the majority had a medical indication and were therefore necessary despite the increased risk of caesarean section. However, approximately 20 % had an elective induction and, women who want induction when there is no medical reason should be counselled about the benefit of postponing induction until amniotomy is possible.

The study is limited by the retrospective design and thus prone to potential confounding. By reviewing all records and by detailed collection of data on maternal, labour and delivery characteristics, an attempt was made to control for confounders, but some may still have been unidentified. Given that a substantial number of women declined participation, the possibility of selection bias must be recognized. To control for changes in management over time, year of delivery was controlled for in the regression analysis. Examples of changes during the study period include: the caesarean section rate before labour has increased; and twin deliveries are planned from 38 instead of 40 weeks’ gestational age. Generalization of the results from the predominantly Scandinavian population to other nationalities may be limited.

This is the first study on twin pregnancies that reports on the risk for caesarean section by induction method. However, women with spontaneous labour onset were used as a control group when the actual alternative is expectant management [15]. Retrospective cohort studies on elective induction (i.e. without medical induction) of labour in a specific week, compared to expectant management in single gestations at term, have not found a difference in risk for caesarean section from 37 weeks gestational age [1620], this is consistent with results from randomized controlled trials [21, 22]. When induction of twin pregnancies has been compared with expectant management, no difference in caesarean section rates have been found, albeit the sample sizes were too small to address the outcome in these studies [14, 23]. Results from singleton pregnancies may not be directly translated to twin pregnancies and, to date, studies large enough to compare expectant management with induction of labour in twin gestations are lacking.

Data on induction of twin pregnancies are limited in the literature and information on the risk of caesarean section related to induction methods is sparse. In a retrospective observational study of induced twin pregnancies, a non-significant higher caesarean delivery rate with vaginally administered misoprostol (n = 57), compared with oxytocin (n = 77), was found [13]. The authors of that study speculated that the higher caesarean section rate was due to the higher rate of nulliparity and unripe cervical status in the misoprostol group. The present study confirms that nulliparity, as well as unripe cervical status, are independent risk factors for caesarean section in induced twin deliveries. In one study of twin gestations, in which outcomes of induced labours (n = 36) were compared with expectant management (n = 45), oxytocin was used in half of induced labours and Foley catheter or vaginal application of Prostaglandin E2 in the other half [14]. There was no difference in caesarean section rates; however, in that study, inductions were not stratified by method used. Another small study of 36 twin pregnancies, randomized to expectant management or induction with oral prostaglandin E2 at 37 gestational weeks, found a non–significant lower rate of caesarean deliveries in the induction group [23]. There were significantly more women with pre labour rupture of membranes in the expectant management group, indicating that the randomization did not result in comparable groups in that study, and maternal infection was the most common indication for caesarean section.

Failed induction, with a caesarean section performed in the latency phase, was a common indication for caesarean section (31 %) in the present study. Studies on the latency phase in twin gestations are sparse and contradictory. One study reports the latent phase to be shorter in twin gestations compared with singletons [24], unlike the finding in a recent cohort study, where twin gestations had significantly less cervical dilation at admission [1]. In singleton gestations, there is data to suggest that latent phase duration is longer in induced compared with spontaneous labour, whereas duration of the active phase is similar [25]. An arrest diagnosis before 6 cm dilation in induced labour is thought better avoided [25] and, by allowing longer duration of the latent phase, unnecessary caesarean deliveries for failed induction can probably be avoided [26].

Twin gestations have slower labour progress compared to singletons, regardless of parity, and require 1–3 hours more to complete the first stage of labour compared with singletons, according to a study by Leftwich and colleagues [1]. The authors of the study propose that patience in providers and patients, concerning the time needed to come through the active phase of twin labours, may reduce caesarean deliveries for failure to progress. Sub analysis of induced labours was not done in that study, although approximately 40 % of labours were induced in both groups and, information on induction method was not described [1]. The results of the present study indicate that when induced labour reaches the active phase, the progress is comparable to those with a spontaneous labour onset. In support of this finding, no difference in mean labour duration was found in previous studies in which induction of twin gestations was compared to expectant management [14, 23].

Twin gestation is associated with an increased risk of morbidity to the neonate. Caesarean section before labour is believed to reduce this risk and is one reason for the increase in caesarean delivery rate seen worldwide [27, 28]. In a recently published randomized controlled trial including twins between 32 and 38 weeks, caesarean section before labour did not reduce the risk of adverse neonatal or maternal outcomes compared with planned vaginal delivery [29]. In contrast, evidence from observational studies suggest there may be some benefit of pre-labour caesarean section for neonates at 36 weeks gestational age and greater, although the absolute rate of adverse neonatal outcome was reported low [3032]. For the woman, a scarred uterus is one important source of morbidity and increases the risk of caesarean section in subsequent deliveries [33, 34]. Given current evidence, a trial of labour in twin pregnancy is still considered a reasonable and safe option [29]. In case of induction, the present study might provide information that could be useful in the counselling of women with a twin gestation.


Compared with spontaneous labour, there is no increase in risk of caesarean section with induction of labour when amniotomy is the method used. There is a possible increased risk of caesarean section associated with induction of labour when Foley catheter or prostaglandins are used, even though the majority will deliver vaginally. When the active phase of labour is reached, the progress is similar in spontaneous and induced labours.



Adjusted odds ratio


Confidence interval


Odds ratio


Standard deviation


Small for gestational age


Statistical package for social sciences


  1. Leftwich HK, Zaki MN, Wilkins I, Hibbard JU. Labor patterns in twin gestations. Am J Obstet Gynecol. 2013;209(3):254 e1–5.

    Article  PubMed  Google Scholar 

  2. Healy AJ, Gaddipati S. Intrapartum management of twins: truths and controversies. Clin Perinatol. 2005;32(2):455–73. 2.

    Article  PubMed  Google Scholar 

  3. Rauh-Hain JA, Rana S, Tamez H, Wang A, Cohen B, Cohen A, et al. Risk for developing gestational diabetes in women with twin pregnancies. J Matern Fetal Neonatal Med. 2009;22(4):293–9.

    Article  PubMed  Google Scholar 

  4. Krotz S, Fajardo J, Ghandi S, Patel A, Keith LG. Hypertensive disease in twin pregnancies: a review. Twin Res. 2002;5(1):8–14.

    Article  PubMed  Google Scholar 

  5. Sibai BM, Hauth J, Caritis S, Lindheimer MD, MacPherson C, Klebanoff M, et al. Hypertensive disorders in twin versus singleton gestations. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstet Gynecol. 2000;182(4):938–42.

    CAS  Article  PubMed  Google Scholar 

  6. Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curet LB, et al. Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol. 2000;95(1):24–8.

    CAS  PubMed  Google Scholar 

  7. Hnat MD, Sibai BM, Caritis S, Hauth J, Lindheimer MD, MacPherson C, et al. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. Am J Obstet Gynecol. 2002;186(3):422–6.

    Article  PubMed  Google Scholar 

  8. Elling SV, McKenna P, Powell FC. Pruritic urticarial papules and plaques of pregnancy in twin and triplet pregnancies. J Eur Acad Dermatol Venereol. 2000;14(5):378–81.

    CAS  Article  PubMed  Google Scholar 

  9. Dodd JM, Deussen AR, Grivell RM, Crowther CA. Elective birth at 37 weeks’ gestation for women with an uncomplicated twin pregnancy. Cochrane Database of Syst Rev. 2014;2, CD003582.

    Google Scholar 

  10. Clark SL, Miller DD, Belfort MA, Dildy GA, Frye DK, Meyers JA. Neonatal and maternal outcomes associated with elective term delivery. Am J Obstet Gynecol. 2009;200(2):156 e1–4.

    Article  PubMed  Google Scholar 

  11. Yeast JD, Jones A, Poskin M. Induction of labor and the relationship to cesarean delivery: A review of 7001 consecutive inductions. Am J Obstet Gynecol. 1999;180(3 Pt 1):628–33.

    CAS  Article  PubMed  Google Scholar 

  12. Fausett MB, Barth Jr WH, Yoder BA, Satin AJ. Oxytocin labor stimulation of twin gestations: effective and efficient. Obstet Gynecol. 1997;90(2):202–4.

    CAS  Article  PubMed  Google Scholar 

  13. Bush MC, Csaba A, Eddleman KA, Saphier CJ. Is misoprostol safe for labor induction in twin gestations? J Matern Fetal Neonatal Med. 2006;19(1):35–8.

    CAS  Article  PubMed  Google Scholar 

  14. Harle T, Brun JL, Leng JJ. Induction of labor in twin pregnancy after 36 weeks does not increase maternal-fetal morbidity. Int J Gynaecol Obstet. 2002;77(1):15–21.

    CAS  Article  PubMed  Google Scholar 

  15. Caughey AB, Nicholson JM, Cheng YW, Lyell DJ, Washington AE. Induction of labor and cesarean delivery by gestational age. Am J Obstet Gynecol. 2006;195(3):700–5.

    Article  PubMed  Google Scholar 

  16. Caughey AB, Sundarman V, Kaimal AJ, Cheng YW, Gienger A, Little SE, et al. Maternal and neonatal outcomes of elective induction of labor. Evid Rep Technol Assess (Full Rep). 2009;176:1–257. Review.

    Google Scholar 

  17. Rasmussen ORS. Cesarean section after induction of labor compared with expectant management: no added risk from gestational week 39. Acta Obstet Gynecol Scand. 2011;90:857–62.

    Article  PubMed  Google Scholar 

  18. Darney BG, Snowden JM, Cheng YW, Jacob L, Nicholson JM, Kaimal A, et al. Elective induction of labor at term compared with expectant management: maternal and neonatal outcomes. Obstet Gynecol. 2013;122(4):761–9.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Osmundson S, Ou-Yang RJ, Grobman WA. Elective induction compared with expectant management in nulliparous women with an unfavorable cervix. Obstet Gynecol. 2011;117(3):583–7.

    Article  PubMed  Google Scholar 

  20. Stock SJ, Ferguson E, Duffy A, Ford I, Chalmers J, Norman JE. Outcomes of elective induction of labour compared with expectant management: population based study. BMJ. 2012;344:e2838.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Gulmezoglu AM, Crowther CA, Middleton P, Heatley E. Induction of labour for improving birth outcomes for women at or beyond term. Cochrane Database of Syst Rev. 2012;6:CD004945.

    Google Scholar 

  22. Caughey AB, Sundaram V, Kaimal AJ, Gienger A, Cheng YW, McDonald KM, et al. Systematic review: elective induction of labor versus expectant management of pregnancy. Ann Intern Med. 2009;151(4):252–63. 4.

    Article  PubMed  Google Scholar 

  23. Suzuki S, Otsubo Y, Sawa R, Yoneyama Y, Araki T. Clinical trial of induction of labor versus expectant management in twin pregnancy. Gynecol Obstet Invest. 2000;49(1):24–7.

    CAS  Article  PubMed  Google Scholar 

  24. Friedman EASM. The effect of uterine over distention on labor. Obstet Gynecol. 1964;23:164–72.

    CAS  PubMed  Google Scholar 

  25. Harper LM, Caughey AB, Odibo AO, Roehl KA, Zhao Q, Cahill AG. Normal progress of induced labor. Obstet Gynecol. 2012;119(6):1113–8.

    Article  PubMed  Google Scholar 

  26. ACOG/SMFM obstetric care consensus. Safe prevention of the primary cesarean section. Am J Obstet Gynecol. 2014;210(3):179–73.

    Article  Google Scholar 

  27. Smith GC, Pell JP, Dobbie R. Birth order, gestational age, and risk of delivery related perinatal death in twins: retrospective cohort study. BMJ. 2002;325(7371):1004.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Official statistics of Sweden. Statistics-Health and Medical Care,Pregnancies, Deliveries and Newborn Infants. In: The Swedish Medical Birth Register 1973–2009. 2011. p. 30. Assisted Reproduction, treatment 1991–2008.

    Google Scholar 

  29. Barrett JF, Hannah ME, Hutton EK, Willan AR, Allen AC, Armson BA, et al. A randomized trial of planned cesarean or vaginal delivery for twin pregnancy. New Eng J Med. 2013;369(14):1295–305.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  30. Hoffmann E, Oldenburg A, Rode L, Tabor A, Rasmussen S, Skibsted L. Twin births: cesarean section or vaginal delivery? Acta Obstet Gynecol Scand. 2012;91(4):463–9.

    Article  PubMed  Google Scholar 

  31. Wenckus DJ, Gao W, Kominiarek MA, Wilkins I. The effects of labor and delivery on maternal and neonatal outcomes in term twins: a retrospective cohort study. BJOG. 2014;121(9):1137–44.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  32. Roberts CL, Algert CS, Nippita TA, Bowen JR, Shand AW. Association of prelabor cesarean delivery with reduced mortality in twins born near term. Obstet Gynecol. 2015;125(1):103–10.

    Article  PubMed  Google Scholar 

  33. Burrows LJ, Meyn LA, Weber AM. Maternal morbidity associated with vaginal versus cesarean delivery. Obstet Gynecol. 2004;103(5 Pt 1):907–12.

    Article  PubMed  Google Scholar 

  34. Villar J, Valladares E, Wojdyla D, Zavaleta N, Carroli G, Velazco A, et al. Caesarean delivery rates and pregnancy outcomes: the 2005 WHO global survey on maternal and perinatal health in Latin America. Lancet. 2006;367(9525):1819–29.

    Article  PubMed  Google Scholar 

Download references


The author thanks all the women who participated in the study.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Maria Jonsson.

Additional information

Competing interests

The author reports no conflict of interest.

Author’s contribution

MJ is the sole author.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jonsson, M. Induction of twin pregnancy and the risk of caesarean delivery: a cohort study. BMC Pregnancy Childbirth 15, 136 (2015).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Bishop score
  • Caesarean section
  • Induction
  • Induction method
  • Labour
  • Twin delivery
  • Twin pregnancy