- Research article
- Open Access
Estimating the prevalence of obstetric fistula: a systematic review and meta-analysis
BMC Pregnancy and Childbirth volume 13, Article number: 246 (2013)
Obstetric fistula is a severe condition which has devastating consequences for a woman’s life. The estimation of the burden of fistula at the population level has been impaired by the rarity of diagnosis and the lack of rigorous studies. This study was conducted to determine the prevalence and incidence of fistula in low and middle income countries.
Six databases were searched, involving two separate searches: one on fistula specifically and one on broader maternal and reproductive morbidities. Studies including estimates of incidence and prevalence of fistula at the population level were included. We conducted meta-analyses of prevalence of fistula among women of reproductive age and the incidence of fistula among recently pregnant women.
Nineteen studies were included in this review. The pooled prevalence in population-based studies was 0.29 (95% CI 0.00, 1.07) fistula per 1000 women of reproductive age in all regions. Separated by region we found 1.57 (95% CI 1.16, 2.06) in sub Saharan Africa and South Asia, 1.60 (95% CI 1.16, 2.10) per 1000 women of reproductive age in sub Saharan Africa and 1.20 (95% CI 0.10, 3.54) per 1000 in South Asia. The pooled incidence was 0.09 (95% CI 0.01, 0.25) per 1000 recently pregnant women.
Our study is the most comprehensive study of the burden of fistula to date. Our findings suggest that the prevalence of fistula is lower than previously reported. The low burden of fistula should not detract from their public health importance, however, given the preventability of the condition, and the devastating consequences of fistula.
The World Health Organisation defines an obstetric fistula (referred to as fistula in the text below) as an “abnormal opening between a woman’s vagina and bladder and/or rectum through which her urine and/or faeces continually leak ”. Classifications of fistula vary, but they generally include fistulae from obstetric causes including vesicovaginal fistula (VVF) and rectovaginal fistula (RVF). Fistulae have devastating consequences [2, 3], particularly in low income countries where women have less geographical and financial access to appropriate surgical care for repair. In high income countries they are also devastating, but they are very rare and surgery to repair them occurs more rapidly.
In high income countries, fistulae are due to iatrogenic causes; generally the result of radiation therapy and surgical interventions . In low income countries where access to intrapartum care may be restricted, fistulae are associated with a prolonged or obstructed labour, most commonly occurring when a baby’s head becomes lodged in the mother’s pelvis cutting off blood flow to the surrounding tissues. Prolonged obstruction can cause the tissues to necrotise leading to fistula formation .
Women with fistulae often experience horrific or difficult associated conditions which stem either from the fistulae itself or from the prolonged or obstructed labour which caused it . The most obvious consequences are incontinence, either urinary , faecal or both. The constant leakage of urine and faeces can also lead to damage to the vulva and thighs . Fistulae are linked with social ostracisation  and marginalisation . Many case series show high rates of divorce or separation [7, 8], absence of sexual intercourse [6, 7], loss of fertility and amenorrhea [9, 10] and depression [8, 11] among women who have a fistula.
Fistulae are thought to have the highest prevalence where maternal mortality is high, but there is great uncertainty about the actual prevalence . In the 2000 Global Burden of Disease, Dolea and AbouZhar estimated that 0.08% of all births and 2.15% of “neglected obstructed labour births” resulted in fistula . These estimates came from four studies only, all of which were in sub-Saharan Africa and two were hospital-based. In 2006, the WHO estimated that more than 2 million young women throughout the world live with untreated fistula, and that between 50,000 and 100,000 new women are affected each year . These statistics originated from countries’ rapid needs assessments and physician’s reports, mostly available in the grey literature, and not from epidemiological studies using robust design, and almost none include a denominator.
In 2007, Stanton and colleagues wrote a paper  on the challenges of quantifying fistula. They described three types of publications reporting on frequency, incidence or prevalence of fistula. The first category of papers relied on secondary and tertiary citations (many of which culminated in personal communications) and reported the number of patients treated without denominators. The second type of publications relied on declarations made by the authors themselves, or on “surgeons’ estimates” but the source of data was unclear. The third type of studies described methods and provided appropriate denominators, but with varying degrees of transparency. Stanton and colleagues were only able to find four papers in this third category .
The aim of our review is to provide improved estimates of the prevalence and incidence of fistula by broadening the search and including studies that may previously have been overlooked. Unlike previous reviews of fistula [12–14], we include studies that examine a broad spectrum of reproductive morbidity (including morbidity studies where fistula is but one of many outcomes studied) and/or where no cases of fistula were reported.
A two-stage systematic review was conducted in accordance with the STROBE guidelines (http://www.strobe-statement.org/) using free-text and subject headings in Pubmed, Embase, Popline, Lilacs, WHO’s Eastern Mediterranean database, and African Index Medicus published until the end of 2012. The first stage targeted studies specifically reporting on fistula in the title, abstract or subject headings, including search terms such as fistula, vesicovaginal fistula, and VVF. The second stage aimed at identifying additional studies that examined postpartum and reproductive morbidity more broadly, whether or not fistula was specifically mentioned as a pathology. This search included terms such as reproductive morbidity and maternal morbidity. A full search strategy is available upon request. Only English terms were used in the search, but articles were not excluded based on language.
Reference lists were searched for additional articles. Using Web of Science, all relevant articles were subjected to forward citation searching to obtain further articles.
As illustrated in Figure 1, the following study designs were included: (i) cross-sectional or cohort studies of fistula with hospital based recruitment of pregnant or recently delivered women where the women were followed for and examined at least 30 days after the end of pregnancy and there was a clear denominator; (ii) cross sectional or cohort studies of prevalent or incident cases of fistula in the community and (iii) cross sectional or cohort studies of prevalent or incident cases of reproductive morbidity in the community. Studies were only included if women were examined for the presence of fistula in hospital and/or if a well trained provider performed a physical examination of the genital area. Morbidity studies not reporting or mentioning fistulae but including a robust design, a thorough physical exam of the genital area that reported cases of uterine prolapse were assumed to have zero cases of fistula, as it was assumed that if fistula had been found it would have been reported. Studies relying on women’s self-reports were excluded because self-reports of reproductive morbidity have been shown to be unreliable [13, 15, 16]. We excluded studies that were conducted before 1990 or published before 1991. We included studies irrespective of sample size but studies without a denominator were excluded. If more than one paper provided results of the same study population, data were first extracted from the article with the greatest amount of information, and supplementary data extracted from the other papers if required.
Data were extracted by a single author (AJA) using a proforma and included information on region, study dates, study population, duration of fistula, type of fistula, risk factors, associated complications and denominators, how fistula were ascertained, sampling technique, number of women and number of deliveries. There are no good tools for looking at study quality in cross-sectional studies, so study quality was assessed using a modified Ottawa-Newcastle score (http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp).
The studies reported on two types of populations of women: women of reproductive age and women with a recent pregnancy. In studies targeting women of reproductive age we calculated the prevalence of fistula per 1000 women of reproductive age. In studies where women were followed after end of pregnancy, we calculated the incidence of fistula per 1000 recently pregnant women (assuming that women were unlikely to have had fistula before getting pregnant). In all cases 95% confidence intervals were calculated using the binomial exact method.
Meta-analyses were conducted using the metaprop command from the R 2.15.3 package meta using a random-effects model . Meta-analyses were conducted summarising the prevalence of fistula among women of reproductive age and the incidence of fistula in recently pregnant women. All studies were stratified by continent and by recruitment in hospital or in the community.
The initial search of studies focussing on fistula found 9130 references after de-duplication, 367 of which were retained after title and abstract screening. From the 367 articles, six were found to have information on either prevalence or incidence of fistula [18–23]. A further 13 studies [24–34] were found from searching general maternal and reproductive morbidity studies (including three from reference lists and forward citation searching [34–36]) (Figure 2).
Of the 19 studies, 13 were community-based; seven of which reported on fistula [18–20, 22, 24, 33, 35] and six did not mention fistula anywhere in the paper. Ten community-based studies reported the prevalence of fistula among women of reproductive age (Table 1) and three reported the incidence among recently pregnant women (Table 2). Six studies recruited women in hospital and followed them for 30 days or more after the end of pregnancy (Table 2). Three studies [21, 23, 36], report the prevalence of fistula among women after having fistula repairs. These studies were included because it was possible to understand the population that these women came from, and have a denominator (Table 1). The other three studies reported the incidence of fistula among women after giving birth or miscarrying in hospital. These studies recruited women with obstetric complications as well as a sample of women without complications [30–32].
Three community-based studies were from sub-Saharan Africa [18, 22, 24], four were from South Asia [19, 20, 33, 35], two were from North Africa [28, 29], three from the Middle East [26, 27, 34], and one from Turkey . All six studies using hospital-based recruitment were from sub-Saharan Africa [21, 23, 30–32, 36].
The prevalence of fistula in community-based studies ranged from 0 to 1.62 per 1000 women of reproductive age with a median of 0 per 1000 (Figure 3). The pooled prevalence of fistula in community-based studies was 0.29 (10 studies including 34,505 participants 95% CI 0.00, 1.07) per 1000 women of reproductive age (Figure 3). The pooled estimate for sub-Saharan Africa and South Asia was 1.13 (4 studies with 29,680 participants 95% CI 0.72, 1.61) per 1000 women of reproductive age (Figure 4). By continent Sub-Saharan Africa had an overall prevalence of 1.60 (two studies including 28,128 participants 95% CI 1.16, 2.10) per 1000 women of reproductive age and South Asia had a prevalence of 1.20 (two studies with 1552 participants 95% CI 0.10, 3.63) per 1000 women of reproductive age (Figure 4). Because all studies from the Middle-East and North Africa had zero events, it is impossible for the meta-analysis to provide a meaningful estimate due to the manner with which zero prevalence studies are dealt with (http://cran.r-project.org/web/packages/meta/meta.pdf).
The prevalence of fistula in studies with hospital-based recruitment ranged from 0.26 to 1.06 per 1000 women of reproductive age, with a median of 0.44 per 1000 women of reproductive age. The pooled estimate of the prevalence of fistula in hospital was 0.51 (three studies with 608,053 participants 95% CI 0.25, 0.87) per 1000 women of reproductive age (Figure 5).
The pooled incidence of fistula in community-based studies was 0.09 (three studies with 21,413 participants 0.01, 0.25) per 1000 recently pregnant women (Figure 6) and in hospital-based studies 0.66 (three studies including 5804 participants 0.16, 1.48) per 1000 recently pregnant women (Figure 7).
The I  values varied substantially by stratum, ranging from 0% in community-based (Figure 6) and hospital-based (Figure 7) incidence studies to 94.8% in prevalence studies with hospital based recruitment (Figure 5). Study quality in the modified Ottawa-Newcastle score table is shown in Table 3. All studies had a cross-sectional or cohort design.
Only two studies reported information on duration of fistula: one found a median of eight years , and the other a median of three years . No community based studies reported on the mode of delivery of the women, or on the cause of fistula.
Our comprehensive systematic review found that fewer than 1 per 1000 women of reproductive age in low and middle income countries suffer from fistula; this figure rises to 1.57 per 1000 when only data from sub-Saharan Africa and South Asia is used. The number of new cases of fistula ranged from 0.09 per 1000 recently pregnant women in community-based studies to 0.66 per 1000 pregnancies in hospital-based studies.
The WHO has suggested that over two million women, mostly from sub-Saharan African and Asian countries, have fistula [1, 37]. Given an estimated population of 645 million women of reproductive age in sub-Saharan Africa and South Asia in 2010 (http://esa.un.org/wpp/unpp/p2k0data.asp), this would suggest that 3 per 1000 women of reproductive age have a fistula, which is considerably higher than our estimate for low and middle income countries. There were too few studies in our review to arrive at robust estimates of the prevalence of fistula by continent, but even the highest estimates for sub-Saharan Africa (1.62 per 1000 women of reproductive age in Ethiopia) or South Asia (2.6 per 1000 in India) fall well short of the WHO estimates. One study  estimated an incidence of 1.239 per 1000 deliveries in rural regions and used this to approximate 33,451 new fistula a year in Sub Saharan Africa. This was based on 2 fistulae found in the “rural region” in the MOMA study. Elsewhere they refer to these regions as “small towns” . They then used the sample of 2 fistulae per 1543 live births to estimate the overall incidence for sub-Saharan Africa. This approach is likely to have over-estimated the number of fistulae patients. First because a substantial proportion of African women now live in cities where the risk of fistulae is likely to be lower than in smaller towns or rural areas; second because the denominator does not include the urban women in larger cities for whom there were no fistulae occurrence.
Overall, we estimate that just over one million women may have a fistula in sub-Saharan Africa and South Asia, and that there are over 6000 new cases per year in these two world regions. Given the devastating consequences of fistula for women and their families, this represents a very substantial burden.
It is possible that community based studies represent an underestimate of the prevalence of fistula, as fistulae are generally more commonly found in regions where there is no access to obstetric care, and may be difficult to reach. These women may have been missed in the studies included here, and the estimates provided here may represent a lower bound estimate of prevalence. However both the studies in Ethiopia  and the Gambia  were conducted in rural areas, and both studies showed very low estimates of prevalence (1.62 and 0.96 respectively).
Our search identified 13 additional studies that would not have been found had the search been restricted to fistula only. This was particularly relevant for community-based prevalence studies, where the specific fistula search only identified four studies, compared to nine when the search was expanded to maternal and reproductive morbidity studies. Inclusion of studies that did not mention fistula could bias the results downwards since it is not certain that women were examined for fistula. However, our strategy of including only studies for which a thorough gynaecological examination was conducted should have ensured that fistula would have been diagnosed and reported if present. Additionally, we only included studies which elicited uterine prolapse, since this implied a thorough examination. Because fistula is a rare condition, it is important to take account of studies that did not find any fistulae, in the same way that studies with negative findings are crucial in systematic reviews of treatment effectiveness .
We were unable to draw solid conclusions about regional variations in the prevalence or incidence of fistula. We only found three community based studies from sub-Saharan Africa and four community-based studies from South Asia (all from India or Bangladesh). Many studies were from very select communities and it is uncertain whether these findings are generalisable to Africa and Asia as a whole. The heterogeneity in prevalence or incidence of fistula in community-based studies was very low however, suggesting that the prevalence and incidence of fistula was uniformly low across all study sites.
It is difficult to estimate the duration of fistula from the reviewed studies because only two papers provided an estimate. However, given that one of these from Malawi had a median duration of three years , and the other from Ethiopia  had a median duration of eight years, it seems that women can live with this condition for a very long time, in some contexts. Other studies have shown that women live with these conditions for years before presenting for fistula repair, sometimes as long as over 20 years . Additionally there was a lack of information on the mode of delivery and cause of the fistula in the community based studies, meaning that it is possible that some women suffered a fistula from causes other than prolonged or obstructed labour.
The low prevalence and incidence of fistula among women recruited in hospital is somewhat unexpected, since women seeking care from hospitals tend to be self-selecting because they are ill. The low incidence among women followed in the community after admission to hospital with near-miss obstetric morbidity (0.9 per 1000 and 1.4 per 1000) [30, 31] is particularly surprising, since this sample would have included a substantial number of women with a prolonged and complicated labour. For example in Benin 27.1% of women had near-miss due to dystocia, which would have included women with both obstructed and prolonged labour . Because these women were recruited in hospital, a timely caesarean section may have prevented the fistula from developing. Reduced fertility is common in women with fistula (due to loss of vagina, amenorrhoea, not engaging in intercourse, and inability to have a live baby) [2, 7, 9], and it is unlikely that women in the included incidence studies would have had a fistula before getting pregnant. Attention should be drawn to the fact that the meta-analysis included one study from Ethiopia that had 76.4% (Figure 3) or 91.3% of the weight in community-based studies (Figure 4), possibly inflating the pooled prevalence estimate.
The low frequency of fistulae in any community make survey enquiries that specifically target the counting of fistula cases prohibitively expensive given the large sample sizes required. Still, all community based studies of reproductive health should explicitly ascertain and report the clinical presence or absence of fistula, even when the sample size is small. .
In many countries in sub-Saharan Africa there is an emphasis on building specialised fistula hospitals dedicated to the treatment of women suffering from fistula. Given the rarity of the condition and the high level of skills and training required for fistulae surgery, the results of this review suggest that the majority of the resources will always be better placed on prevention rather than cure. Strengthening maternal health services, creating conditions for better transportation and communication networks and training of local providers into the management of emergency complications, including with caesarean sections, would have the additional effect of providing care for other causes of maternal and perinatal mortality and morbidity.
The relative rarity of fistula should not detract from their public health importance. The estimated 6000 new cases of fistula per year in sub-Saharan Africa and South Asia are a painful testament to the continued failure of health systems to manage labour complications effectively. Caesarean sections remain inaccessible to a large number of women in sub-Saharan Africa . Delays in accessing caesarean sections, faulty techniques and lack of caesarean sections all contribute to the burden of fistula. The fact that fistula have virtually disappeared in high income countries suggest that they are entirely preventable. Given the seriousness of the condition, and the devastating consequences of fistula for women and their families, efforts should also be made to find these women and treat them.
Our study is the most comprehensive study of the burden of fistula to date, including study sources not generally used. Our findings suggest that the prevalence and incidence of fistula is relatively low. The low burden of fistula should not detract from their public health importance, however, given the preventability of the condition, and the devastating consequences of fistula. Future studies of fistula should include a description of the study population with defined denominators.
WHO: Obstetric fistula: guiding principles for clinical management and programme development. 2006, Geneva: World Health Organization
Wall LL, Arrowsmith SD, Briggs ND, Browning A, Lassey A: The obstetric vesicovaginal fistula in the developing world. Obste & gyne survey. 2005, 60 (7 Suppl 1): S3-S51.
Danso KA, Martey JO, Wall LL, Elkins TE: The epidemiology of genitourinary fistulae in Kumasi, Ghana, 1977-1992. Int Urogynecol J Pelvic Floor Dysfunct. 1996, 7 (3): 117-120. 10.1007/BF01894198.
Langkilde NC, Pless TK, Lundbeck F, Nerstrom B: Surgical repair of vesicovaginal fistulae–a ten-year retrospective study. Scand J Urol Nephrol. 1999, 33 (2): 100-103. 10.1080/003655999750016069.
Karateke A, Cam C, Ozdemir A, Guney B, Vatansever D, Celik C: Characteristics of obstetric fistulas and the need for a prognostic classification system. Archives of Med Sci. 2010, 6 (2): 253-256.
Muleta M, Hamlin EC, Fantahun M, Kennedy RC, Tafesse B: Health and social problems encountered by treated and untreated obstetric fistula patients in rural Ethiopia. J Obstet Gynaecol Can. 2008, 30 (1): 44-50.
Wall LL, Karshima JA, Kirschner C, Arrowsmith SD: The obstetric vesicovaginal fistula: characteristics of 899 patients from Jos, Nigeria. Am J Obstet Gynecol. 2004, 190 (4): 1011-1019. 10.1016/j.ajog.2004.02.007.
Browning A, Fentahun W, Goh JT: The impact of surgical treatment on the mental health of women with obstetric fistula. BJOG. 2007, 114 (11): 1439-1441. 10.1111/j.1471-0528.2007.01419.x.
Hilton P, Ward A: Epidemiological and surgical aspects of urogenital fistulae: a review of 25 years’ experience in southeast Nigeria. Int Urogynecol J Pelvic Floor Dysfunct. 1998, 9 (4): 189-194. 10.1007/BF01901602.
Holme A, Breen M, MacArthur C: Obstetric fistulae: a study of women managed at the Monze Mission Hospital, Zambia. BJOG. 2007, 114 (8): 1010-1017. 10.1111/j.1471-0528.2007.01353.x.
Goh JT, Sloane KM, Krause HG, Browning A, Akhter S: Mental health screening in women with genital tract fistulae. BJOG. 2005, 112 (9): 1328-1330. 10.1111/j.1471-0528.2005.00712.x.
Dolea C, AbouZhar C: Global Burden of Obstructed Labour in the Year 2000. 2003, Geneva: World Health Organisation, http://www.who.int/healthinfo/statistics/bod_obstructedlabour.pd,
Stanton C, Holtz SA, Ahmed S: Challenges in measuring obstetric fistula. Int J Gynaecol Obstet. 2007, 99 (Suppl 1): S4-S9.
Leung TY, Chung TKH: Severe chronic morbidity following childbirth. Best Prac Res Clin Obstet Gynaecol. 2009, 23 (3): 401-423. 10.1016/j.bpobgyn.2009.01.002.
Ronsmans C, Achadi E, Cohen S, Zazri A: Women’s recall of obstetric complications in south Kalimantan Indonesia. Stud Fam Plann. 1997, 28 (3): 203-214. 10.2307/2137888.
Filippi V, Ronsmans C, Gandaho T, Graham W, Alihonou E, Santos P: Women’s reports of severe (near-miss) obstetric complications in Benin. Stud Fam Plann. 2000, 31 (4): 309-324. 10.1111/j.1728-4465.2000.00309.x.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR: A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Syn Methods. 2010, 1 (2): 97-111. 10.1002/jrsm.12.
Muleta M, Fantahun M, Tafesse B, Hamlin EC, Kennedy RC: Obstetric fistula in rural Ethiopia. East Afr Med J. 2007, 84 (11): 525-533.
Bhatia JC, Cleland J, Bhagavan L, Rao NS: Levels and determinants of gynecological morbidity in a district of south India. Stud Fam Plann. 1997, 28 (2): 95-103. 10.2307/2138112.
Fronczak N, Antelman G, Moran AC, Caulfield LE, Baqui AH: Delivery-related complications and early postpartum morbidity in Dhaka, Bangladesh. Int J of Gynecology & Obstetrics. 2005, 91 (3): 271-278. 10.1016/j.ijgo.2005.09.006.
Kalilani-Phiri LV, Umar E, Lazaro D, Lunguzi J, Chilungo A: Prevalence of obstetric fistula in Malawi. Int J Gynaecol Obstet. 2010, 109 (3): 204-208. 10.1016/j.ijgo.2009.12.019.
Vangeenderhuysen C, Prual A, Ould el Joud D: Obstetric fistulae: incidence estimates for sub-Saharan Africa. Int J Gynaecol Obstet. 2001, 73 (1): 65-66. 10.1016/S0020-7292(00)00374-X.
Ijaiya MA, Aboyeji PA: Obstetric urogenital fistula: the Ilorin experience Nigeria. West Afr J Med. 2004, 23 (1): 7-9.
Walraven G, Scherf C, West B, Ekpo G, Paine K, Coleman R, Bailey R, Morison L: The burden of reproductive-organ disease in rural women in The Gambia West Africa. Lancet. 2001, 357 (9263): 1161-1167. 10.1016/S0140-6736(00)04333-6.
Bulut A, Filippi V, Marshall T, Nalbant H, Yolsal N, Graham W: Contraceptive choice and reproductive morbidity in Istanbul. Stud Fam Plann. 1997, 28 (1): 35-43. 10.2307/2137969.
Al-Qutob R, Mawajdeh S, Massad D: Can a home-based pelvic examination be used in assessing reproductive morbidity in population-based studies? A Jordanian experience. J Adv Nurs. 2001, 33 (5): 603-612. 10.1046/j.1365-2648.2001.01707.x.
Deeb ME, Awwad J, Yeretzian JS, Kaspar HG: Prevalence of reproductive tract infections, genital prolapse, and obesity in a rural community in Lebanon. Bull World Health Organ. 2003, 81 (9): 639-645.
Al-Riyami A, Afifi M, Morsi M, Mabry R: A national study of gynecological morbidities in Oman Effect of women’s autonomy. Saudi Med J. 2007, 28 (6): 881-890.
Younis N, Khattab H, Zurayk H, el-Mouelhy M, Amin MF, Farag AM: A community study of gynecological and related morbidities in rural Egypt. Stud Fam Plann. 1993, 24 (3): 175-186. 10.2307/2939232.
Filippi V, Ganaba R, Baggaley RF, Marshall T, Storeng KT, Sombié I, Ouattara F, Ouedraogo T, Akoum M, Meda N: Health of women after severe obstetric complications in Burkina Faso: a longitudinal study. Lancet. 2007, 370 (9595): 1329-1337. 10.1016/S0140-6736(07)61574-8.
Filippi V, Goufodji S, Sismanidis C, Kanhonou L, Fottrell E, Ronsmans C, Alihonou E, Patel V: Effects of severe obstetric complications on women’s health and infant mortality in Benin. Trop Med Int Health. 2010, 15 (6): 733-742. 10.1111/j.1365-3156.2010.02534.x.
Prual A, Huguet D, Garbin O, Rabe G: Severe obstetric morbidity of the third trimester, delivery and early puerperium in Niamey (Niger). Afr J Reprod Health. 1998, 2 (1): 10-19.
Ferdous J, Ahmed A, Dasgupta SK, Jahan M, Huda FA, Ronsmans C, Koblinsky M, Chowdhury ME: Occurrence and determinants of postpartum maternal morbidities and disabilities among women in Matlab, Bangladesh. J Health and Pop Nutrition. 2012, 30 (2): 143-158.
Tehrani RF: Reproductive morbidity among Iranian women; issues often inappropriately addressed in health seeking behaviors. BMC Public Health. 2011, 11: 863-10.1186/1471-2458-11-863.
Kulkarni R: Magnitude and determinants of chronic obstetric morbidities in Nasik District in Maharashtra. Indian Council for Medical Research 2007. 2007, Available at: http://www.icmrnicin/annual/2007-08/nirrh/chapter5pdf 2007
Mabeya HM: Characteristics of women admitted with obstetric fistula in the rural hospitals in west Pokot, Kenya. Postgraduate training course in reproductive health 2004. 2004, Available at http://wwwgfmerch/Medical_education_En/PGC_RH_2004/Obstetric_fistula_Kenyahtm accessed Sept 6, 2011 2004
Health E, UNFPA: Obstetric fistula needs assessment report: Findings from nine African countries. 2003, New York: UNFPA
Prual A, Bouvier-Colle MH, de Bernis L, Breart G: Severe maternal morbidity from direct obstetric causes in West Africa: incidence and case fatality rates. Bull World Health Organ. 2000, 78 (5): 593-602.
Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Edited by: Higgins JPT, Green S. 2011, The Cochrane Collaboration, Available from http://www.cochrane-handbook.org
Ronsmans C, Holtz S, Stanton C: Socioeconomic differentials in caesarean rates in developing countries: a retrospective analysis. Lancet. 2006, 368 (9546): 1516-1523. 10.1016/S0140-6736(06)69639-6.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/13/246/prepub
The authors would like to thank Doris Chou, Lale Say, and Herbert Peterson for their comments.
This research was funded through a grant made to the Child Health Epidemiology Reference Group (CHERG) by the Bill and Melinda Gates Foundation.
The author’s declare that they have no competing interests.
AJA conducted search, extracted data, did analysis and wrote first draft of paper CR advised on methodology and commented on drafts CC commented on drafts and helped in writing of paper VF helped design study and commented on paper. All authors read and approved the final manuscript.
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Adler, A.J., Ronsmans, C., Calvert, C. et al. Estimating the prevalence of obstetric fistula: a systematic review and meta-analysis. BMC Pregnancy Childbirth 13, 246 (2013). https://doi.org/10.1186/1471-2393-13-246
- Vesicovaginal fistula
- Maternal morbidity
- Systematic review