Caesarean delivery and subsequent pregnancy interval: a systematic review and meta-analysis
© O’Neill et al. licensee BioMed Central Ltd. 2013
Received: 9 June 2013
Accepted: 13 August 2013
Published: 27 August 2013
Caesarean delivery has increased worldwide, however, the effects on fertility are largely unknown. This systematic review aims to compare subsequent sub-fertility (time to next pregnancy or birth) among women with a Caesarean delivery to women with a vaginal delivery.
Systematic review of the literature including seven databases: CINAHL; the Cochrane Library; Embase; Medline; PubMed; SCOPUS and Web of Knowledge (1945 - October 2012), using detailed search-strategies and reference list cross-checking. Cohort, case–control and cross-sectional studies were included. Two assessors reviewed titles, abstracts, and full articles using standardised data abstraction forms and assessed study quality.
11 articles were eligible for inclusion in the systematic review, of these five articles which adjusted for confounders were combined in a meta-analysis, totalling 750,407 women using fixed-effect models. Previous Caesarean delivery was associated with an increased risk of sub-fertility [pooled odds ratio (OR) 0.90; 95% CI 0.86, 0.93]. Subgroup analyses by parity [primiparous women: OR 0.91; 95% CI 0.87, 0.96; not limited to primiparous women: OR 0.81; 95% CI 0.73, 0.90]; by publication date (pre-2000: OR 0.80, 95% CI 0.68, 0.94; post-2000: OR 0.90, 95% CI 0.86, 0.94); by length of follow-up (<10 years: OR 0.81, 95% CI 0.73, 0.90; >10 years: OR 0.91, 95% CI 0.87, 0.96); by indication for mode of delivery (specified: 0.92, 95% CI 0.88, 0.97; not specified: OR 0.81, 95% CI 0.73, 0.90); by cohort size (<35,000: OR 0.79, 95% CI 0.67, 0.92; >35,000: OR 0.90, 95% CI 0.87, 0.95), by definition of sub-fertility used divided into (birth interval [BI]: OR 0.89, 95% CI 0.84, 0.94; inter-pregnancy interval [IPI]: OR 0.91, 95% CI 0.85, 0.97; and categorical measures: OR 0.81, 95% CI 0.73, 0.90); continuous measures: OR 0.91, 95% CI 0.87, 0.96) were performed. Results of the six studies not included in the meta-analysis (which did not adjust for confounders) are presented individually.
The meta-analysis shows an increased waiting time to next pregnancy and risk of sub-fertility among women with a previous Caesarean delivery. However, included studies are limited by poor epidemiological methods such as variations in the definition of time to next pregnancy, lack of confounding adjustment, or details of the indication for Caesarean delivery. Further research of a more robust methodological quality to better explore any underlying causes of sub-fertility and maternal intent to delay childbearing is warranted.
Over the past three decades, rates of Caesarean delivery have increased dramatically worldwide [1, 2]. In the United Kingdom (UK) for example, 2% of all births were delivered via Caesarean section in 1953, 18% in 1997 and 21% in 2001 . In 2010, the Caesarean delivery rate was 24.8% in the UK . Statistics from 2010–2011 for Australia and the United States of America (USA) show almost one in every three pregnant women has a Caesarean delivery [5, 6].
A number of possible biological mechanisms for an association between Caesarean delivery and sub-fertility have been postulated including infection at the site of the wound, scar adhesion and placental bed disruption . The waiting time to next pregnancy or birth is reported to be a robust surrogate marker of sub-fertility in the literature . A number of studies to date have assessed the long-term consequences of Caesarean delivery on subsequent fertility [7, 9, 10] including two reviews [11, 12]. To date, few studies have found that women with a Caesarean delivery are less likely to have a subsequent pregnancy and have a longer pregnancy interval compared to women with a vaginal delivery, even after adjustment for parity [9, 11, 13–15]. In addition, one study examined a sub-group of women with pre-eclampsia and it was reported that women who delivered by Caesarean were 20% less likely to have another pregnancy . Other studies have claimed a Caesarean delivery does not affect future fertility [17, 18].
A recent systematic review and meta-analysis investigating the rate of continuation to a subsequent pregnancy reported that women with a previous Caesarean delivery are 9% less likely to have a subsequent pregnancy and 11% less likely to have a subsequent birth . This systematic review however did not meta-analyse subsequent pregnancy interval, which is arguably a more robust marker of sub-fertility. However, it must be noted that women who have a Caesarean delivery may differ in many respects, for example, in height, age, body mass index (BMI) and obstetric history. Thus, any association between mode of delivery and subsequent sub-fertility may be confounded by a variety of medical, obstetrical, social and socioeconomic confounding factors [19–23]. Furthermore, residual confounding such as the indication for Caesarean delivery may explain part or all of the association between Caesarean delivery and sub-fertility .
There are an estimated 70 million couples worldwide who are infertile and the long-term clinical outcomes associated with sub-fertility are uncertain . With one in every six couples reported to be seeking fertility treatment  any potential association between mode of delivery and subsequent sub-fertility could have major social, clinical and public health implications.
Therefore, the purpose of this systematic review and meta-analysis is to update, compile and critically review the existing evidence on the effects of a Caesarean delivery on the waiting time to subsequent pregnancy or birth and to provide a quantitative estimate of the overall relationship between mode of delivery and subsequent sub-fertility.
The main objective of this systematic review and meta-analysis is to collect and interpret the published literature on the association between a Caesarean delivery and subsequent sub-fertility (time to next pregnancy or birth) and to calculate a pooled estimate of the odds of sub-fertility following a Caesarean delivery.
Inter-pregnancy interval (IPI), defined as the time passed since the termination of the previous pregnancy and the conception of the next pregnancy, or
Birth interval (BI) defined as the time elapsed from the date of delivery of the previous child to the date of delivery of the subsequent child.
The outcome will be a dichotomous measure of the time to next pregnancy within the follow-up time period reported in each study. Where a study reports estimates of two separate intervals as a measure of sub-fertility (i.e. a period of >1 year or a period of >3 years trying to conceive), the longer time interval will be used in the meta-analysis. Furthermore, where a study provides stratified estimates and sub-group analyses, only the overall estimate of sub-fertility will be included in the meta-analysis.
Data were from an original study (i.e. no review articles, editorials or commentaries).
Study design: cohort, cross-sectional or case–control studies, in which mode of delivery and the subsequent IPI or BI were reported.
Outcome definitions: studies which defined sub-fertility using the standard pregnancy interval definitions (IPI or BI) were considered appropriate for inclusion in the systematic review and meta-analysis.
Reporting of an adjusted effect estimate (relative risk [RR], odds ratio [OR], or hazard ratio [HR]) or sufficient data in order to calculate these estimates of the relationship between Caesarean delivery and subsequent sub-fertility.
Study selection and data abstraction
Titles and abstracts of studies retrieved from the search strategy were reviewed independently applying the appropriate inclusion and exclusion criteria by the researchers. The full text article was obtained for all potentially eligible studies for further appraisal. Using a standardised data abstraction form, two assessors (SMON, ASK) individually entered the following data from each study: first author’s name, year, study design, location of the study (country), study period and follow-up, data source (i.e. hospital database, nationwide registers, patient records), total sample size, measure of pregnancy interval used (IPI or BI, and whether it was measured as a continuous or categorical outcome), statistical tests used, the indication for Caesarean delivery (breech, elective, emergency), the population sampled (i.e. primiparous, multiparous women), the exclusion criteria and the main results and conclusions of each study. Discrepancies in data abstraction between assessors were resolved through consensus.
The primary analysis estimated the relationship between prior Caesarean delivery and subsequent sub-fertility (pregnancy interval between the index and subsequent pregnancy) compared to women with a prior vaginal delivery. The generic inverse variance method with a fixed-effect model was used to calculate pooled estimates across the studies. A funnel plot was produced to estimate the likelihood of publication bias using the pooled OR and standard error (SE). Only studies which reported adjusting for a minimum of three confounders including maternal age were included in the meta-analysis. Studies which reported crude estimates are presented individually in a separate table.
Firstly, we estimated separate ORs by parity (primiparous versus not limited to primiparous women), to assess the degree of confounding by number of previous deliveries. Secondly, we estimated the pooled OR by publication date (pre-2000, post 2000). Thirdly, we performed an analysis by length of follow-up (<10 years, >10 years). Next we performed a separate analysis based on whether an indication for mode of delivery was available or not (yes, not specified). Next we carried out an analysis by cohort size (<35,000, >35,000) and finally by definition of sub-fertility used: (a) BI versus IPI and (b) categorical measures (e.g. <1 year, >3 years) vs. continuous measures
Analyses were performed using Review Manager version 5.1 software .
Heterogeneity between the included studies was assessed by examining the differences in study characteristics including study setting (high-income developed country versus low-income developing country), study design (case–control, cohort or cross-sectional), sampling frame (population-based or single/select institutions), and definition of the outcome measure used. In the meta-analysis, we used the I2 statistic to ascertain statistical heterogeneity, following the Cochrane Handbook for Systematic Reviews threshold recommendations . An I2 statistic value between 0% and 40% suggests heterogeneity may not be important; 30% to 60% represents moderate heterogeneity; 50% to 90% represents substantial heterogeneity; and 75% to 100% represents considerably significant heterogeneity. The magnitude and direction of the effects (Chi-squared test P-value, 95% confidence interval for I2) determine the importance of the I2 statistic according to the handbook.
The methodological quality was assessed using a quality assessment tool based on six different types of bias common in observational studies (selection, exposure, outcome, analytic, attrition and confounding) for each study included in the review. This bias classification tool has been described in detail elsewhere . Study bias was recorded as minimal, low, moderate or high according to the perceived degree of bias present for each of the six types of bias. For example, for confounding factor bias a study would be classified as minimal in bias if it adjusted for at least three key confounders including maternal age. An overall likelihood of bias was then estimated based on the total amount of bias perceived to be present.
Ethical approval was not required for this systematic review and meta-analysis as it did not include any experimental research on humans or personal information which would otherwise require informed consent.
Database search results
Characteristics of studies included in the review
Characteristics of studies included in the systematic review
Country/ Study design
Study period/ Follow-up
Statistical tests used
Indication for Caesarean
Eijsink, 2008 
Holland / Cohort
1998-2002/ Follow-up to 2005
Single hospital database
Breech emergency & elective
Multiple deliveries, congenital malformations, uterine anomalies
Collin, 2006 
Sub-Saharan Africa / Cohort
1993-2003/ Minimum follow-up 3 years
Cross-sectional standardised survey data from 22 countries
IPI ( >1 or <5 years)
Women with >1 terminated pregnancy; women currently breastfeeding; abstaining from intercourse or using contraception; women in South Africa (due to high elective Caesarean rates); stillbirths; women outside 14–49 years of age
Smith, 2006 
Scotland / Cohort
1980-1984/ Follow-up to 1999
Emergency, elective for breech, all other pre-labour Caesarean
Multiple births, preterm births, perinatal deaths, missing values
Murphy, 2002 
UK / Cohort
1991-1992/ Minimum follow-up 3 years
Self-completed questionnaire data
IPI (>1 or >3 years)
Women with unplanned pregnancies
Zdeb, 1984 
1975/ Follow-up for 5 years
Single hospital database
Stillbirths, high-forceps, mid-forceps, breech, version and extraction deliveries
Tollånes, 2007 
1969-1996/ Follow-up to 2003
Nationwide Birth Register
Breech, pre-eclampsia, low-risk Caesarean groups
Women dying aged <50, women who changed partners, multiple pregnancies
Tower, 2000 
UK / Cohort
1992-1993/ Follow-up for 5 years
Single hospital database
BI, IPI (scale)
Failure to progress, fetal distress
Huttly, 1990 
1982/ Follow-up for 4 years
Data obtained from interview of mothers
BI (within 35–52 months)
Tubal ligation/ sterilisation
1973, 1976/ Follow-up for 5 years
Nationwide Birth Register survey data
BI (<5 years)
Hysterectomy, non-Swedish women, rare blood groups, multiple pregnancies, malformations, birth weight <2000g, perinatal death
LaSala, 1987 
USA/ Case control
1978/ Follow-up for 3 years
Single hospital logbook
BI (>2 years)
Missing hospital records, sterilisation, women using contraception
1957-1982/ Minimum 1 year follow-up, maximum 25 years
Nationwide Birth Register
Women outside 15–44 years of age; women living in Alaska or Hawaii; women with no live births or more than two abortions; multiple births; missing data; perinatal deaths; birth weight <1500g; women who put their child up for adoption
Three studies used national registers [16, 18, 37], three used smaller databases (i.e. a single hospital obstetric database) [17, 32, 33], four studies used interview or questionnaire survey data [7, 10, 34, 36], and one study used patient medical records . Eight studies included primiparous women only (i.e. those women with only one previous pregnancy) [16–18, 32, 33, 35–37] and three were not limited to primiparous women [7, 10, 34]. Studies included 10 cohort [7, 10, 16–18, 32–34, 36, 37], and one case–control . Indication for mode of delivery was reported in four studies [16–18, 32]. Exclusion criteria, confounder adjustment and matching techniques varied between studies and only one study was conducted in a low-income region (Sub-Saharan Africa) .
Primary outcome analysis
Subgroup analyses of the impact of Caesarean section on subsequent sub-fertility (time to next pregnancy or birth)
Number of studies included
Pooled OR estimate (95% CI)
Overall pooled estimate
n = 5
0.90 [0.86, 0.93]
Primiparous women only
n = 2
0.91 [0.87, 0.96]
Not limited to primiparous women
n = 3
0.81 [0.73, 0.90]
By publication date
n = 1
0.80 [0.68, 0.94]
n = 4
0.90 [0.86, 0.94]
Length of follow-up
n = 3
0.81 [0.73, 0.90]
n = 2
0.91 [0.87, 0.96]
Indication for mode of delivery
n = 2
0.92 [0.88, 0.97]
n = 3
0.81 [0.73, 0.90]
By cohort size
n = 2
0.79 [0.67, 0.92]
n = 3
0.90 [0.87, 0.95]
By definition of sub-fertility used
a. Birth Interval (BI)
n = 2
0.89 [0.84, 0.94]
Inter-pregnancy interval (IPI)
n = 3
0.91 [0.85, 0.97]
b. Categorical measure (e.g. > 3 years)
n = 3
0.81 [0.73, 0.90]
Continuous measure (e.g. median IPI)
n = 2
0.91 [0.87, 0.96]
Results of studies included in the systematic review (but not the meta-analysis)
Inter-pregnancy interval (IPI)
Main findings of studies included in the systematic review
Eijsink et al., 2008 
Median IPI: Elective CS breech (22mths), Emergency CS (18 mths), Vaginal breech (16 mths), Reference [home birth] (18 mths)
In women with a breech delivery, a longer IPI among the elective CS group was reported, however there were only 35 women in this group
Zdeb et al., 1984 
Median IPI in mths: 21.8
No significant difference in the timing of subsequent pregnancies among the two groups
#Tower et al., 2000 
Median BI (IQR) in mths: CS failure to progress (32, 23–45); CS fetal distress (34, 25–46); SVD (32, 23–44)
No evidence that women delivering by Caesarean section have significantly longer waiting times to next pregnancy or birth
Median IPI (IQR) in mths: CS failure to progress (28, 22–40); CS fetal distress (31, 24–44); SVD (29, 22–39)
Hemminki, 1987 
BI: Subsequent pregnancy within 5 years 1973 cohort- RR (0.91, 95% CI 0.89, 0.93); 1976 cohort RR (0.91, 95% CI 0.89, 1.12)
Proportion of women with a previous Caesarean section less likely to have a subsequent delivery, although no significant difference found
LaSala, 1987 
BI: CS delivery (5.5%) >2 years without conceiving; vaginal delivery (1.4%) >2 years without conceiving
Women with a previous Caesarean were less likely to have a subsequent birth and took longer to conceive than women with a previous vaginal delivery. However the sample size was very small
Hemminki et al., 1985 
Median BI (mths): CS delivery (44.4); vaginal delivery (45.6)
No significant difference in waiting time to next birth among women with a previous Caesarean section compared to women with a previous vaginal delivery
Birth interval (BI)
Three studies used BI as the measure of association between a Caesarean delivery and time to next birth [35–37]. One study reported a longer BI among women with a Caesarean delivery. La Sala et al.  reported that 5.5% of women with a Caesarean delivery compared to 1.4% of women with a vaginal delivery took greater than two years to conceive. Two studies negate such findings and reported no delay in time to next birth among women with a Caesarean delivery [36, 37]. One study  reported both the IPI and BI and showed that no evidence existed to show that a Caesarean delivery was associated with a longer time to next pregnancy or birth.
The heterogeneity of the 11 included studies is presented in Table 1, where the different characteristics including sample size, region, population sampling and data sources are outlined. Ten of the 11 studies were cohort studies. Only one study  was conducted in a low-income developing country. In addition, the studies were conducted in varying time periods, including one study from the 1950’s to early 1980’s . Seven studies collected information from single institutions or interviews and questionnaire data. The I2 statistic was used to quantify statistical heterogeneity and ranged from 0% to 88%, a high amount of heterogeneity between the studies. Definitions of pregnancy interval used varied between studies, with 44% heterogeneity in studies using BI compared to 45% heterogeneity in studies using IPI.
Quality assessment of studies included in the systematic review
Outcome assessment bias
Confounding factor bias*
Overall likelihood of bias
Eijsink et al., 2008 
High (no adjustment for confounders reported, matched by maternal age and date of delivery)
Collin et al., 2006 
Minimal (adjusted for age, parity, level of education, urban or rural residence and young age at first intercourse)
Smith et al., 2006 
Minimal (adjusted for marital status, deprivation, birth weight, infant sex, maternal age, maternal height and method of induction)
Murphy et al., 2002 
Minimal (adjusted for maternal and paternal age, co-habitation, oral contraceptive pill use, cigarette exposure, alcohol consumption, educational level, ethnicity, parity, change of partner, maternal BMI)
Zdeb et al., 1984 
Moderate (none reported). Matching by race, complications of pregnancy, maternal education and maternal age
Tollånes et al., 2007 
Minimal (stratified by maternal age, level of education and infant survival). Sub-group analyses by low-risk group, pre-eclampsia and breech presentation
Tower et al., 2000 
Moderate (no adjustment for confounding). Matching by age and date of delivery
Huttly et al., 1990 
Minimal (adjusted for income, age, education and parity)
Hemminki, 1987 
Moderate (no adjustment for confounders). Matching by year of birth, maternal age and infant sex
LaSala et al., 1987 
Moderate (no adjustment for confounding reported). Matching by age and parity
Hemminki et al., 1985 
Moderate (no adjustment reported). Matching by date of birth, mother’s age, race and marital status
The overall findings of the meta-analysis suggest that there is a 10% increased risk of subsequent sub-fertility following Caesarean delivery compared to vaginal delivery. This finding persisted in the various sensitivity analyses undertaken including parity, publication date, length of follow-up, indication for mode of delivery, cohort size and by definition of sub-fertility used. However, it must be stated that the extent of subsequent sub-fertility was less pronounced among primiparous women (9%), studies published since 2000 (9%), and where the indication for mode of delivery was known (8%). The findings of this systematic review and meta-analysis are in agreement with a recent systematic review  which reported that patients who had undergone a Caesarean section had a 9% lower subsequent pregnancy rate [RR 0.91, 95% CI 0.87, 0.95] and an 11% lower birth rate [RR 0.89, 95% CI 0.87, 0.92], compared with women who delivered vaginally, and thus that previous Caesarean delivery was associated with an increased risk of subsequent sub-fertility. However, in contrast to the present systematic review, the authors focused on subsequent pregnancy rate following Caesarean delivery compared to vaginal delivery as the primary outcome measure of sub-fertility and did not include time to next pregnancy or birth in their meta-analysis. In addition, we identified two further papers for inclusion in the meta-analysis on pregnancy interval which were not included by Gurol-Urganci et al. [7, 10].
Findings from the six studies included in the systematic review (but not the meta-analysis) produced conflicting results. It is possible that the findings reported in these studies are due to poor epidemiological methods used, including small sample size, inability to adjust for confounding, no indication for mode of delivery, and significant variations in the measurement of the outcome variable (time to next pregnancy or birth). However, from the meta-analysis it can be seen that the studies which found an association between Caesarean delivery and a longer waiting time to next pregnancy or birth [10, 16, 18] were of a more methodologically superior quality, including large sample size, population-based registries and had detailed obstetrical information including the indication for Caesarean delivery, maternal obstetric history and a long period of follow-up.
It can be argued however that residual or unknown confounders or maternal choice to intentionally delay next birth may explain any delay in waiting time to next birth and that the sub-fertility observed may not be as a result of Caesarean delivery [16, 18]. According to Bhattacharya et al.  voluntary factors responsible for intentionally delayed subsequent pregnancies include social and financial factors such as lifestyle, age, educational attainment and lack of a partner. Previous experience of labour and delivery are also vital factors affecting the decision to delay or avoid another pregnancy in women. This view is also discussed by Porter et al.  and Kjerulff et al.  both of whom argue that the mechanism behind subsequent sub-fertility could be social or psychological rather than pathological.
Strengths and limitations of the review
Strengths of the review include the thoroughness of the literature search which included seven databases, two reviewers, a detailed search-strategy compiled with a team of obstetricians and epidemiologists and rigorous cross-checking of reference lists. Furthermore, no date or language restrictions were enforced. Unfortunately, limitations to this review include firstly that any systematic review is limited by the quality of the original data collected, especially with observational studies. For example, only five out of the 11 included studies adjusted for potential confounders [7, 10, 16, 18, 34], and the other six studies used matching to reduce the likelihood of bias [17, 32, 33, 35–37]. It was not possible to meta-analyse the six studies which only presented crude estimates as each reported pregnancy interval using very different measures making it impossible to combine the estimates. Sample sizes were quite small in three of the studies that reported an association [32, 35, 36] and thus the findings may be due to chance. Furthermore, the indication for mode of delivery (instrumental vaginal, vaginal breech, elective caesarean section, emergency caesarean section, etc.) was available in only two of the meta-analysed studies [16, 18] and so confounding by indication may also exist in some of the included studies. Short periods of follow-up may also be an issue, as some women were followed for short periods including: one year , three years , four years  and five years [17, 33, 37], which may not be a sufficient amount of time to allow for a subsequent pregnancy in some cases. The loss of a child and the desire to replace the loss is another important factor that is not acknowledged in all studies, with only one study stratifying analyses based on infant survival or death within the first year .
Finally, to know whether there is any association between Caesarean delivery and subsequent sub-fertility, it would be necessary to know whether women were deliberately delaying pregnancy (difficult deliveries in the past, desired family size obtained, oral contraceptive use, varying recommendations by doctors on the optimal time to wait following a Caesarean delivery before trying for another baby again, or change of partner). It is also not possible to establish whether any fertility treatment was used by the study populations. This in itself would be a major confounder as a woman who was already sub-fertile may have an increased risk of sub-fertility in the future. Ideally, subsequent research using registry data for instance, should aim to access the fertility registers (available in the Scandinavian countries for example) in order to exclude or account for certain groups such as women with a history of poor reproductive outcomes or women who accessed fertility treatments such as in vitro fertilisation (IVF). Sub-group analyses by other important risk factors such as advanced maternal age should also be prioritised. The main focus should be on the likelihood and timing of a subsequent pregnancy in women with a previous Caesarean section compared to vaginal delivery where no adverse outcomes occur (i.e. in live births only) in order to minimise the bias of pre-existing sub-fertility. In this review, only three studies used a cohort of women actively trying to conceive again [7, 10, 36]. It was possible to include two out these three studies in a sub-group analysis of women actively trying to conceive, generating a pooled OR of 0.82 (95% CI 0.72, 0.94) as the rate of subsequent sub-fertility. Secondly, only published literature was included in this systematic review and so publication bias may be cited as a reason for insufficient validity. It is however unlikely that any large study was missed due to the thoroughness of the literature search.
Methodological issues in measuring time to pregnancy
Much of the research to date investigating a woman’s fertility has been based on time to pregnancy studies, with retrospective designs using a well-defined target population, which are cheaper to conduct with the added benefit of higher external validity compared to prospective studies . However, methodological issues exist in time to pregnancy studies including the inability to obtain detailed time-specific information about behaviour and risk factors . Appropriate study design can minimise the biases associated with time to pregnancy studies according to Joffe et al. , who describe three main sampling frames: 1) pregnancy-based studies recruiting pregnant or recently delivered women who are easy to define, gain access to and recall bias is minimal, but sterile couples are excluded and sub-fertile couples under-represented; 2) cross-sectional population-based or occupationally-based studies where couples are randomly selected from the general population or an occupational group and a detailed obstetric history can be retrieved on one or more pregnancies, and failed attempts. However, long recall may lead to possible bias, for exposure variables and covariates; 3) population-based birth cohort studies use a previously defined birth cohort, who are questioned about their reproductive history, allowing for a longitudinal aspect of factors from earlier life to be studied. The sampling frames of each study included in the systematic review can be found in the supplementary material (Additional file 3).
Different biases including selection bias (including successful pregnancy attempts only), ‘wantedness’ bias (where couples say that a pregnancy was planned when it was not for fear of appearing not to want the child), planning bias (excluding couples with accidental or unplanned pregnancies), and pregnancy recognition bias (where a pregnancy is identified very early into the gestation may result in miscarriage in some cases) can be controlled if studies are well-designed and conducted, and through the use of appropriate sensitivity analyses in properly selected populations . Time to pregnancy data has shown to be valid even where there is a recall of 20 years, although non-birth outcomes such as miscarriage are more commonly excluded [40, 43–45].
Based on the findings of the studies included in this meta-analysis, previous Caesarean delivery is associated with an increase in subsequent sub-fertility (i.e. a delay in time to next pregnancy or birth) compared to vaginal delivery by as much as 14%. With Caesarean rates at the highest ever recorded, the average age of first-time mothers increasing gradually and primary elective Caesarean delivery common practice, it is important that clinicians and expectant mothers fully discuss the potential benefits and risks associated with not only Caesarean deliveries, but all modes of delivery and together make an informed decision on an individual basis. [13, 46]. The underlying mechanisms for an association between Caesarean delivery and subsequent sub-fertility remains unclear and for this reason, there is an urgent need for prospective research with large sample sizes and appropriate acknowledgement of potential key confounders. Further research is needed with a more thorough approach using a combination of quantitative and qualitative methods to address women’s views of their experiences [47–49]. Even if an increased waiting time to next pregnancy or birth is reported it could still be due to biological or psychological factors and therefore, the woman’s opinion about the length of acceptable pregnancy interval is perhaps the most important predicting factor and should be incorporated into future research where possible.
We would like to acknowledge the staff of the National Perinatal Epidemiology Centre, The Department of Epidemiology and Public Health and the INFANT Research Centre for their support on this project. We would also like to acknowledge Professor John Browne of the Department of Epidemiology and Public Health in University College Cork (UCC) for his didactic postgraduate course ‘Systematic Reviews for the Health Sciences’ as well as Cathal Kerrigan (Librarian) in the Brookfield Health Sciences Complex, UCC.
This work was conducted as part of the Irish Health Research Board (HRB) PhD Scholars Programme in Health Services Research, Grant No: PhD/2007/16 and funded by the National Perinatal Epidemiology Centre (NPEC) in Cork University Maternity Hospital, Wilton, Cork, Ireland.
- Roberts CL, Algert CS, Ford JB, Todd AL, Morris JM: Pathways to a rising caesarean section rate: a population-based cohort study. BMJ Open. 2012, 2 (5): 10.1136/bmjopen-2012-001725.Google Scholar
- Orfali K: Beyond Numbers: The Multiple Cultural Meanings of Rising Cesarean Rates Worldwide. Am J Bioeth. 2012, 12 (7): 54-56. 10.1080/15265161.2012.680544.View ArticlePubMedGoogle Scholar
- Lavender T, Hofmeyr G, Neilson J, Kingdon C, Gyte G: Caesarean section for non-medical reasons at term. Cochrane Database Syst Rev. 2006, 3: 10.1002/14651858.CD004660.pub2.Google Scholar
- ICHSC: The Information Centre for Health and Social Care. England: Maternity Statistics, 2009–10 Publication date: November 18th 2010Google Scholar
- Hamilton BE, Hoyert DL, Martin JA, Strobino DM, Guyer B: Annual Summary of Vital Statistics: 2010–2011. Pediatr. 2013, 131 (3): 548-558. 10.1542/peds.2012-3769.View ArticleGoogle Scholar
- Chen MM, Hancock H: Women's knowledge of options for birth after Caesarean Section. Women Birth. 2012, 25 (3): e19-e26. 10.1016/j.wombi.2011.08.001.View ArticlePubMedGoogle Scholar
- Murphy DJ, Stirrat GM, Heron J: The relationship between Caesarean section and subfertility in a population-based sample of 14 541 pregnancies. Hum Reprod. 2002, 17 (7): 1914-1917. 10.1093/humrep/17.7.1914.View ArticlePubMedGoogle Scholar
- Maheshwari A, Bhattacharya S, Johnson NP: Predicting fertility. Hum Fertil. 2008, 11 (2): 109-117. 10.1080/14647270701832346.View ArticleGoogle Scholar
- Bahl R, Strachan B, Murphy DJ: Outcome of subsequent pregnancy three years after previous operative delivery in the second stage of labour: cohort study. BMJ. 2004, 328 (7435): 311-314. 10.1136/bmj.37942.546076.44.View ArticlePubMedPubMed CentralGoogle Scholar
- Collin SM, Marshall T, Filippi V: Caesarean section and subsequent fertility in sub-Saharan Africa. BJOG. 2006, 113 (3): 276-283. 10.1111/j.1471-0528.2006.00846.x.View ArticlePubMedGoogle Scholar
- Hemminki E: Impact of caesarean section on future pregnancy–a review of cohort studies. Paediatr Perinat Epidemiol. 1996, 10 (4): 366-379. 10.1111/j.1365-3016.1996.tb00062.x.View ArticlePubMedGoogle Scholar
- Gurol-Urganci I, Bou-Antoun S, Lim C, Cromwell D, Mahmood T, Templeton A, van der Meulen J: Impact of Caesarean section on subsequent fertility: a systematic review and meta-analysis. Hum Reprod. 2013, 28 (7): 1943-1952. 10.1093/humrep/det130.View ArticlePubMedGoogle Scholar
- Porter M, Bhattacharya S, Van Teijlingen E, Templeton A: Does Caesarean section cause infertility?. Hum Reprod. 2003, 18 (10): 1983-1986. 10.1093/humrep/deg402.View ArticlePubMedGoogle Scholar
- Mollison J, Porter M, Campbell D, Bhattacharya S: Primary mode of delivery and subsequent pregnancy. BJOG. 2005, 112 (8): 1061-1065. 10.1111/j.1471-0528.2005.00651.x.View ArticlePubMedGoogle Scholar
- Jolly J, Walker J, Bhabra K: Subsequent obstetric performance related to primary mode of delivery. BJOG. 1999, 106 (3): 227-232. 10.1111/j.1471-0528.1999.tb08235.x.View ArticleGoogle Scholar
- Tollanes MC, Melve KK, Irgens LM, Skjaerven R: Reduced fertility after cesarean delivery: a maternal choice. Obstet Gynecol. 2007, 110 (6): 1256-1263. 10.1097/01.AOG.0000292089.18717.9f.View ArticlePubMedGoogle Scholar
- Tower CL, Strachan BK, Baker PN: Long-term implications of caesarean section. J Obstet Gynaecol. 2000, 20 (4): 365-367. 10.1080/01443610050111959.View ArticlePubMedGoogle Scholar
- Smith GC, Wood AM, Pell JP, Dobbie R: First cesarean birth and subsequent fertility. Fertil Steril. 2006, 85 (1): 90-95. 10.1016/j.fertnstert.2005.07.1289.View ArticlePubMedGoogle Scholar
- Smith GC, Pell JP, Dobbie R: Caesarean section and risk of unexplained stillbirth in subsequent pregnancy. Lancet. 2003, 362 (9398): 1779-1784. 10.1016/S0140-6736(03)14896-9.View ArticlePubMedGoogle Scholar
- Pandian Z, Bhattacharya S, Templeton A: Review of unexplained infertility and obstetric outcome: a 10 year review. Hum Reprod. 2001, 16 (12): 2593-2597. 10.1093/humrep/16.12.2593.View ArticlePubMedGoogle Scholar
- Saraswat L, Porter M, Bhattacharya S, Bhattacharya S: Caesarean section and tubal infertility: is there an association?. Reprod Biomed Online. 2008, 17 (2): 259-264. 10.1016/S1472-6483(10)60203-9.View ArticlePubMedGoogle Scholar
- Khashan A, Kenny L: The effects of maternal body mass index on pregnancy outcome. Eur J Epidemiol. 2009, 24 (11): 697-705. 10.1007/s10654-009-9375-2.View ArticlePubMedGoogle Scholar
- Kenny LC, Lavender T, McNamee R, O’Neill SM, Mills T, Khashan AS: Advanced Maternal Age and Adverse Pregnancy Outcome: Evidence from a Large Contemporary Cohort. PLoS ONE. 2013, 8 (2): e56583-10.1371/journal.pone.0056583.View ArticlePubMedPubMed CentralGoogle Scholar
- Parikh NI, Cnattingius S, Mittleman MA, Ludvigsson JF, Ingelsson E: Subfertility and risk of later life maternal cardiovascular disease. Hum Reprod. 2012, 27 (2): 568-575. 10.1093/humrep/der400.View ArticlePubMedGoogle Scholar
- Balen AH, Rutherford AJ: Management of infertility. BMJ. 2007, 335 (7620): 608-611. 10.1136/bmj.39324.662049.80.View ArticlePubMedPubMed CentralGoogle Scholar
- Previous caesarean delivery and subsequent pregnancy interval: a systematic review. PROSPERO: International prospective register of systematic reviews. CRD42012003166 http://www.crd.york.ac.uk/PROSPERO/register_new_review.asp?RecordID=3166&UserID=1850
- Moher D, Liberati A, Tetzlaff J, Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009, 339: b2535-10.1136/bmj.b2535.View ArticlePubMedPubMed CentralGoogle Scholar
- Cochrane: Review Manager (RevMan). 5.1 edn. 2012, Copenhagen: The Nordic Cochrane Centre: The Cochrane CollaborationGoogle Scholar
- Higgins JPT, Green S: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. 2011, The Cochrane Collaboration, Available from http://handbook.cochrane.org/ Google Scholar
- McDonald SD, Murphy K, Beyene J, Ohlsson A: Perinatel outcomes of singleton pregnancies achieved by in vitro fertilization: a systematic review and meta-analysis. J Obstet Gynaecol Can. 2005, 27 (5): 449-View ArticlePubMedGoogle Scholar
- Albrechtsen S, Rasmussen S, Dalaker K, Irgens LM: Reproductive career after breech presentation: subsequent pregnancy rates, interpregnancy interval, and recurrence. Obstet Gynecol. 1998, 92 (3): 345-350. 10.1016/S0029-7844(98)00176-8.PubMedGoogle Scholar
- Eijsink JJ, van der Leeuw-Harmsen L, van der Linden PJ: Pregnancy after Caesarean section: fewer or later?. Hum Reprod. 2008, 23 (3): 543-547. 10.1093/humrep/dem428.View ArticlePubMedGoogle Scholar
- Zdeb M, Therriault G, Logrillo V: Frequency, spacing, and outcome of pregnancies subsequent to primary cesarean childbirth. Am J Obstet Gynecol. 1984, 150 (2): 205-View ArticlePubMedGoogle Scholar
- Huttly SR, Barros FC, Victora CG, Lombardi C, Vaughan JP: Subsequent pregnancies: who has them and who wants them? Observations from an urban center in southern Brazil. Rev Saude Publica. 1990, 24 (3): 212-216. 10.1590/S0034-89101990000300007.View ArticlePubMedGoogle Scholar
- LaSala A, Berkeley A: Primary cesarean section and subsequent fertility. Am J Obstet Gynecol. 1987, 157 (2): 379-View ArticlePubMedGoogle Scholar
- Hemminki E, Graubard BI, Hoffman HJ, Mosher WD, Fetterly K: Cesarean section and subsequent fertility: results from the 1982 National Survey of Family Growth. Fertil Steril. 1985, 43 (4): 520-528.View ArticlePubMedGoogle Scholar
- Hemminki E: Pregnancy and birth after cesarean section: a survey based on the Swedish birth register. Birth. 1987, 14 (1): 12-17. 10.1111/j.1523-536X.1987.tb01443.x.View ArticlePubMedGoogle Scholar
- Bhattacharya S, Porter M, Harrild K, Naji A, Mollison J, Van Teijlingen E, Campbell D, Hall M, Templeton A: Absence of conception after caesarean section: voluntary or involuntary?. BJOG. 2006, 113 (3): 268-275. 10.1111/j.1471-0528.2006.00853.x.View ArticlePubMedGoogle Scholar
- Kjerulff KH, Velott DL, Zhu J, Chuang CH, Hillemeier MM, Paul IM, Repke JT: Mode of First Delivery and Women's Intentions for Subsequent Childbearing: Findings from the First Baby Study. Paediatr Perinat Epidemiol. 2013, 27 (1): 62-71. 10.1111/ppe.12014.View ArticlePubMedGoogle Scholar
- Joffe M, Key J, Best N, Keiding N, Scheike T, Jensen TK: Studying time to pregnancy by use of a retrospective design. Am J Epidemiol. 2005, 162 (2): 115-124. 10.1093/aje/kwi172.View ArticlePubMedGoogle Scholar
- Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P: Selection bias in determining the age dependence of waiting time to pregnancy. Am J Epidemiol. 2000, 152 (6): 565-572. 10.1093/aje/152.6.565.View ArticlePubMedGoogle Scholar
- Olsen J, Juul S, Basso O: Measuring time to pregnancy. Methodological issues to consider. Hum Reprod. 1998, 13 (7): 1751-1753. 10.1093/humrep/13.7.1751.View ArticlePubMedGoogle Scholar
- Baird DD, Weinberg CR, Schwingl P, Wilcox AJ: Selection bias associated with contraceptive practice in time‒to‒pregnancy studies. Ann N Y Acad Sci. 2006, 709 (1): 156-164.View ArticleGoogle Scholar
- Olsen J: Design options and sources of bias in time-to-pregnancy studies. Scand J Work Environ Health. 1999, 25 (Suppl 1): 5-7. discussion 76-8.PubMedGoogle Scholar
- Bonde JP, Joffe M, Sallmén M, Kristensen P, Olsen J, Roeleveld N, Wilcox A: Validity issues relating to time-to-pregnancy studies of fertility. Epidemiol. 2006, 17 (4): 347-349. 10.1097/01.ede.0000210239.80406.46.View ArticleGoogle Scholar
- Jolly M, Sebire N, Harris J, Robinson S, Regan L: The risks associated with pregnancy in women aged 35 years or older. Hum Reprod. 2000, 15 (11): 2433-2437. 10.1093/humrep/15.11.2433.View ArticlePubMedGoogle Scholar
- Emmett C, Shaw A, Montgomery A, Murphy D: Women’s experience of decision making about mode of delivery after a previous caesarean section: the role of health professionals and information about health risks. BJOG. 2006, 113 (12): 1438-1445. 10.1111/j.1471-0528.2006.01112.x.View ArticlePubMedGoogle Scholar
- Moffat M, Bell J, Porter M, Lawton S, Hundley V, Danielian P, Bhattacharya S: Decision making about mode of delivery among pregnant women who have previously had a caesarean section: A qualitative study. BJOG. 2006, 114 (1): 86-93. 10.1111/j.1471-0528.2006.01154.x.View ArticleGoogle Scholar
- Eden KB, Hashima JN, Osterweil P, Nygren P, Guise JM: Childbirth preferences after cesarean birth: a review of the evidence. Birth. 2004, 31 (1): 49-60. 10.1111/j.0730-7659.2004.0274.x.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/13/165/prepub
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