Table 4 Association of pre-BMI and adverse pregnancy outcomes stratified by MTHFR C667T dominant model.

Pregnancy outcomes

BMI status

CC

CT + TT

P for interaction^#

OR2 (95% CI)

OR2 (95% CI)

GDM

Normal weight

1 (ref)

1 (ref)

0.216

Underweight

0.68 (0.49–0.93) *

0.76 (0.54–1.07)

Overweight

1.64 (1.10–2.42) *

1.84 (1.23–2.75) *

Obesity

1.90 (0.94–3.86)

2.40 (1.28–4.47) *

GHT

Normal weight

1 (ref)

1 (ref)

0.474

Underweight

0.77 (0.47–1.24)

0.51 (0.28–0.91)

Overweight

3.02 (1.82–5.01) *

1.82 (1.02–3.23) *

Obesity

4.72 (2.13–10.45) *

2.51 (1.07–5.84) *

CS

Normal weight

1 (ref)

1 (ref)

0.582

Underweight

0.59 (0.46–0.76) *

0.74 (0.58–0.96) *

Overweight

1.10 (0.76–1.55)

1.98 (1.38–2.85) *

Obesity

2.61 (1.32–5.17) *

2.70 (1.46–4.97) *

PROM

Normal weight

1 (ref)

1 (ref)

0.184

Underweight

0.85 (0.65–1.11)

0.97 (0.76–1.30)

Overweight

0.92 (0.59–1.42)

1.06 (0.69–1.61)

Obesity

0.50 (0.19–1.31)

0.77 (0.36–1.59)