Table 1 List of outcome measures
Measure | Measured by | Objectives |
|---|---|---|
MPF biology | ||
- Placental corticotropin-releasing hormone (CRH) - Interleukin (IL)-6, - C-reactive protein (CRP) - Cortisol | - Blood and saliva sample during pregnancy at T1 and T2 | To measure and analyse differences in endocrine and immune stress markers during pregnancy |
Birth and developmental outcomes | ||
- Birth weight & length - Birth outcomes (delivery, complications) - Length of gestation | - Abstraction of medical data from obstetric record at birth | |
- Current weight & length - Chronic disease - Physical disabilities - Mental disabilities - Neurodevelopmental disorders | - Abstraction of medical data from obstetric and child examination records at birth and during routine child health examinations (“U-Untersuchungen”) in first month of life | To measure birth and infant anthropometric and developmental outcomes and their association with mothers MPF biology during pregnancy |
- Reported developmental physical impairments - Reported neurodevelopmental disorders | - Reported by mother at T3 | |