Burden of hepatitis E virus infection in pregnancy and maternofoetal outcomes: a systematic review and meta-analysis

Table 1 Meta-analysis prevalence of hepatitis E virus infection in the global population of pregnant women

	Prevalence (95% confidence intervals)	95% prediction intervals	N Studies	N Participants	Heterogeneity			p Egger test	p difference
	Prevalence (95% confidence intervals)	95% prediction intervals	N Studies	N Participants	H (95% confidence intervals)	I² (95% confidence intervals)	p	p Egger test	p difference
Symptomatic	49.6 (42.6–56.7)	13.6–85.9	32	3696	4.2 (3.7–4.6)	94.2 (92.7–95.4)	< 0.0001	0.739	< 0.0001
Asymptomatic	3.4 (1.2–6.4)	0.0–24.3	19	7967	6.1 (5.4–6.8)	97.3 (96.6–97.9)	< 0.0001	0.633
*By HDI*
Asymptomatic
Low and medium HDI	5.0 (0.8–11.9)	0.0–41.6	9	3678	7.3 (6.2–8.5)	98.1 (97.4–98.6)	< 0.0001	0.551	0.410
High and very high HDI	2.6 (0.6–5.5)	0.0–19.6	12	5781	5.4 (4.6–6.4)	96.6 (95.3–97.5)	< 0.0001	0.473
Symptomatic
Low and medium HDI	49.6 (42.6–56.7)	13.6–85.9	32	3696	4.2 (3.7–4.6)	94.2 (92.7–95.4)	< 0.0001	0.739	NA
High and very high HDI	–	–	0	–	–	–	–	–

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