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Table 3 Adjusted effect of delivery modes on quintiles of IL-1β, TNF-α, IL-6, IFN-γ, IL-8, IL-10 and HO-1 mRNA expression of maternal placenta

From: Placenta response of inflammation and oxidative stress in low-risk term childbirth: the implication of delivery mode

Cytokines Groups Quantile regressions
  10th 25th 50th 75th 90th
IL-1β CDMI 0.11(−0.28,0.51) 0.03(−0.21,0.26) −0.26(−0.51,-0.01)* −0.20(−0.49,0.09) −0.23(−0.59,0.13)
CDMR 0.09(−0.25,0.43) −0.14(−0.38,0.10) −0.23(−0.50,0.03) −0.30(−0.43,-0.17)* −0.45(−0.67,-0.22)*
UCD 0.43(−0.35,1.21) 0.39(−0.14,0.92) −0.07(−0.57,0.44) −0.01(−0.58,0.58) −0.41(−1.53,0.71)
TNF-α CDMI 0.20(−0.21,0.62) 0.15(−0.19,0.49) 0.12(−0.11,0.34) −0.01(−0.30,0.28) −0.02(−0.47,0.44)
CDMR 0.31(−0.04,0.67) 0.27(−0.06,0.60) 0.20(−0.02,0.41) 0.03(−0.21,0.27) 0.06(−0.19,0.31)
UCD 0.34(−0.51,1.19) 0.36(−0.19,0.90) −0.02(−0.83,0.79) −0.06(−1.36,1.24) 1.11(−0.60,2.83)
IL-6 CDMI 0.56(0.30,0.81)* 0.04(−0.12,0.20) 0.11(−0.07,0.28) −0.06(−0.30,0.19) 0.06(−0.25,0.38)
CDMR 0.39(0.55,0.73)* 0.15(−0.03,0.33) 0.19(−0.03,0.41) 0.27(0.09,0.45)* 0.20(0.06,0.35)*
UCD 0.37(−0.50,1.25) 0.26(−0.10,0.62) 0.58(−0.41,0.53) −0.31(−0.92,0.29) 0.64(−1.38,2.65)
IFN-γ CDMI 0.20(−0.31,0.71) 0.12(−0.32,0.57) −0.15(−0.46,0.17) −0.14(−0.40,0.11) −0.20(−0.69,0.28)
CDMR 0.12(−0.25,0.48) 0.17(−0.39,0.72) −0.07(−0.35,0.20) −0.25(−0.48,-0.02)* −0.23(−0.62,0.15)
UCD −0.13(−2.21,1.94) 0.32(−0.45,1.10) 0.05(−1.15,1.26) 0.33(−0.65,1.31) 0.26(−0.45,0.97)
IL-8 CDMI 0.03(−0.21,0.28) −0.17(−0.48,0.14) −0.21(−0.53,0.11) −0.32(−0.63,-0.01)* −0.37(−0.62,-0.13)*
CDMR −0.07((−0.30,0.16) −0.34(−0.56,-0.11)* −0.40(−0.64,-0.16)* −0.40(−0.63,-0.17)* −0.29(−0.53,-0.06)*
UCD 0.15(−0.36,0.67) −0.27(−0.90,0.36) −0.01(−0.71,0.70) 0.10(−0.96,1.16) −0.19(−1.25,0.86)
IL-10 CDMI −0.06(−0.34,0.23) −0.02(−0.31,0.27) 0.01(−0.34,0.35) 0.03(−0.44,0.49) 0.07(−0.24,0.38)
CDMR −0.02(−0.27,0.23) −0.15(−0.41,0.11) −0.19(−0.45,0.07) 0.01(−0.42,0.43) 0.26(−0.23,0.75)
UCD −0.17(−1.00.0.65) 0.07(−0.50,0.65) −0.19(−0.76,0.38) −0.71(−1.13,-0.29)* −0.35(−1.70,1.00)
HO-1 CDMI 0.18(−0.28,0.64) 0.25(0.04,0.45)* 0.30(0.10,0.50)* 0.01(−0.25,0.26) 0.31(−0.09,0.71)
CDMR 0.13(−0.17,0.43) 0.24(−0.04,0.52) 0.37(0.21,0.53)* 0.23(−0.01,0.48) 0.41(0.04,0.78)*
UCD 0.11(−0.74,0.96) 0.26(−0.33,0.84) −0.01(−0.31,0.28) 0.17(−0.68,1.02) −0.18(−0.74,0.39)
  1. Data were presented by quantile regression coefficients and 95% CIs (Confidence intervals) which based on above cytokines mRNA expression. Vaginal delivery group was regarded as control; CDMI cesarean delivery with medical indication, CDMR cesarean deliveryon maternal request, UCD urgent cesarean delivery
  2. Model was adjusted by these variables: pre pregnancy BMI, maternal age, gravidity, previous adverse pregnant outcome, pregnancy-specific Anxiety Score in 1st, 2nd and 3rd trimester, birth weight, gestational age, infant gender and placental size
  3. *P values less than 0.05 were considered significant (two-sided)