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Table 3 Adjusted effect of delivery modes on quintiles of IL-1β, TNF-α, IL-6, IFN-γ, IL-8, IL-10 and HO-1 mRNA expression of maternal placenta

From: Placenta response of inflammation and oxidative stress in low-risk term childbirth: the implication of delivery mode

Cytokines

Groups

Quantile regressions

 

10th

25th

50th

75th

90th

IL-1β

CDMI

0.11(−0.28,0.51)

0.03(−0.21,0.26)

−0.26(−0.51,-0.01)*

−0.20(−0.49,0.09)

−0.23(−0.59,0.13)

CDMR

0.09(−0.25,0.43)

−0.14(−0.38,0.10)

−0.23(−0.50,0.03)

−0.30(−0.43,-0.17)*

−0.45(−0.67,-0.22)*

UCD

0.43(−0.35,1.21)

0.39(−0.14,0.92)

−0.07(−0.57,0.44)

−0.01(−0.58,0.58)

−0.41(−1.53,0.71)

TNF-α

CDMI

0.20(−0.21,0.62)

0.15(−0.19,0.49)

0.12(−0.11,0.34)

−0.01(−0.30,0.28)

−0.02(−0.47,0.44)

CDMR

0.31(−0.04,0.67)

0.27(−0.06,0.60)

0.20(−0.02,0.41)

0.03(−0.21,0.27)

0.06(−0.19,0.31)

UCD

0.34(−0.51,1.19)

0.36(−0.19,0.90)

−0.02(−0.83,0.79)

−0.06(−1.36,1.24)

1.11(−0.60,2.83)

IL-6

CDMI

0.56(0.30,0.81)*

0.04(−0.12,0.20)

0.11(−0.07,0.28)

−0.06(−0.30,0.19)

0.06(−0.25,0.38)

CDMR

0.39(0.55,0.73)*

0.15(−0.03,0.33)

0.19(−0.03,0.41)

0.27(0.09,0.45)*

0.20(0.06,0.35)*

UCD

0.37(−0.50,1.25)

0.26(−0.10,0.62)

0.58(−0.41,0.53)

−0.31(−0.92,0.29)

0.64(−1.38,2.65)

IFN-γ

CDMI

0.20(−0.31,0.71)

0.12(−0.32,0.57)

−0.15(−0.46,0.17)

−0.14(−0.40,0.11)

−0.20(−0.69,0.28)

CDMR

0.12(−0.25,0.48)

0.17(−0.39,0.72)

−0.07(−0.35,0.20)

−0.25(−0.48,-0.02)*

−0.23(−0.62,0.15)

UCD

−0.13(−2.21,1.94)

0.32(−0.45,1.10)

0.05(−1.15,1.26)

0.33(−0.65,1.31)

0.26(−0.45,0.97)

IL-8

CDMI

0.03(−0.21,0.28)

−0.17(−0.48,0.14)

−0.21(−0.53,0.11)

−0.32(−0.63,-0.01)*

−0.37(−0.62,-0.13)*

CDMR

−0.07((−0.30,0.16)

−0.34(−0.56,-0.11)*

−0.40(−0.64,-0.16)*

−0.40(−0.63,-0.17)*

−0.29(−0.53,-0.06)*

UCD

0.15(−0.36,0.67)

−0.27(−0.90,0.36)

−0.01(−0.71,0.70)

0.10(−0.96,1.16)

−0.19(−1.25,0.86)

IL-10

CDMI

−0.06(−0.34,0.23)

−0.02(−0.31,0.27)

0.01(−0.34,0.35)

0.03(−0.44,0.49)

0.07(−0.24,0.38)

CDMR

−0.02(−0.27,0.23)

−0.15(−0.41,0.11)

−0.19(−0.45,0.07)

0.01(−0.42,0.43)

0.26(−0.23,0.75)

UCD

−0.17(−1.00.0.65)

0.07(−0.50,0.65)

−0.19(−0.76,0.38)

−0.71(−1.13,-0.29)*

−0.35(−1.70,1.00)

HO-1

CDMI

0.18(−0.28,0.64)

0.25(0.04,0.45)*

0.30(0.10,0.50)*

0.01(−0.25,0.26)

0.31(−0.09,0.71)

CDMR

0.13(−0.17,0.43)

0.24(−0.04,0.52)

0.37(0.21,0.53)*

0.23(−0.01,0.48)

0.41(0.04,0.78)*

UCD

0.11(−0.74,0.96)

0.26(−0.33,0.84)

−0.01(−0.31,0.28)

0.17(−0.68,1.02)

−0.18(−0.74,0.39)

  1. Data were presented by quantile regression coefficients and 95% CIs (Confidence intervals) which based on above cytokines mRNA expression. Vaginal delivery group was regarded as control; CDMI cesarean delivery with medical indication, CDMR cesarean deliveryon maternal request, UCD urgent cesarean delivery
  2. Model was adjusted by these variables: pre pregnancy BMI, maternal age, gravidity, previous adverse pregnant outcome, pregnancy-specific Anxiety Score in 1st, 2nd and 3rd trimester, birth weight, gestational age, infant gender and placental size
  3. *P values less than 0.05 were considered significant (two-sided)