- Research article
- Open Access
Quality of guidelines on the management of diabetes in pregnancy: a systematic review
BMC Pregnancy and Childbirth volume 12, Article number: 58 (2012)
Diabetes during pregnancy can lead to severe risks for both mother and fetus when it is not managed properly. The use of rigorously developed guidelines with a robust implementation process can have a positive influence on the management of diabetes during pregnancy. This study aims to compare recommendations and assess the quality of clinical guidelines on gestational diabetes mellitus (GDM) and pre-existing diabetes mellitus during pregnancy.
Guidelines were selected by searching PubMed, the Guideline Clearing House and Google. All guidelines developed since 2000 on diabetes during pregnancy in English or Dutch were considered. Recommendations of the guidelines were compared. Furthermore, the quality was assessed by two authors independently, using the AGREE instrument.
Eight guidelines were included. According to the AGREE instrument, the quality of most guidelines was low. The domains editorial independence, stakeholder involvement and rigour of development had the lowest scores. Recommendations were mainly comparable on glycemic control, preconceptional counseling and prenatal care and labour. Differences between recommendations were found for screening on GDM and induction of labour.
The quality of most guidelines concerning the management of diabetes during pregnancy needs to be improved. A more systematic approach in the development of these guidelines, more attention for updating procedures and piloting of the guidelines and involvement of target users and patients is recommended.
Diabetes during pregnancy can lead to serious risks for both mother and fetus . The management of diabetes differs between women with gestational diabetes mellitus (GDM) and pregnant women with pre-existing diabetes mellitus type 1 (DM1) or type 2 (DM2).
GDM develops often towards the end of the second trimester . Maternal risk factors for GDM are: a BMI above 30 kg/m², history of unexplained intrauterine fetal death, previous GDM or a macrosomic baby, family history of DM, polycystic ovarian syndrome and ethnicity. Especially women of South Asian, Black Caribbean and Middle Eastern origin have an increased risk of GDM [2–4]. After delivery, GDM usually resolves. However, both mother and child have an increased risk of developing DM2 later in life.
In the Netherlands, the prevalence of GDM is estimated between 1-15%, depending on the study population . The highest prevalence is found in non-Dutch women. Because of migration and the increasing prevalence of obesity, it is likely that the number of pregnancies complicated by GDM will increase.
DM1 and DM 2 affect 1% of pregnancies, but this is probably an underestimation . Due to the increasing prevalence of DM2 caused by obesity in a younger age group, it is assumed that the prevalence of pregnancies complicated by DM2 will increase as well.
The possible complications due to diabetes during pregnancy are severe. The mother has an increased risk of pre-eclampsia, infections, ketoacidosis, hypoglycemia and micro-vascular diseases such as retinopathy, nephropathy and neuropathy . In addition, there is an increased risk for miscarriage, still birth, congenital defects and neonatal morbidity and death . For congenital defects, a dose-response relation is found: the poorer the periconceptional blood glucose control, the greater is the risk on congenital defects . Another major complication is macrosomia, which is a risk factor for instrumental delivery, caesarean section, shoulder dystocia during delivery and neonatal hypoglycemia directly after birth .
There is strong evidence that proper management of GDM and pre-existing DM during pregnancy leads to better health outcomes for both mother and child [1, 11]. To ensure proper management, several guidelines from different countries, institutes and organisations concerning the management of diabetes during pregnancy have been published. In general, guidelines are important instruments for improving the quality of health care. They should be based on the best available evidence and should also take patient preferences and clinical experience into account . Furthermore, an effective strategy for the implementation of recommendations is an important next step for realising proper management.
So far, the quality of guidelines concerning diabetes in pregnancy has not been established. Therefore, the aim of this study was to assess the quality of guidelines on diabetes during pregnancy by an internationally acknowledged instrument. In addition, the recommendations for the management of diabetes during pregnancy were compared.
Selection of guidelines
To identify relevant clinical guidelines, the database of PubMed (Medline) was searched up to October 2011 using the following terms: diabetes, gestational diabetes and pregnancy and limited by ‘clinical guidelines’. Because guidelines are often not published in medical journals, the search was extended to the Internet by screening the Guideline Clearing House and Google. When searching these databases, the following terms were used: clinical guidelines, diabetes, gestational diabetes and pregnancy. The authors checked the links in Google until saturation was reached.
To be included in this study, guidelines had to meet the following criteria:
the patient group consisted of pregnant women with GDM or pre-existing DM, 2) the guideline addressed the management of GDM or pre-existing DM during pregnancy, 3) full text was available on the internet, 4) the guideline concerned Western populations and 5) the guideline was available in the English or Dutch language.
Guidelines were excluded if they focused on the management of diabetes mellitus in general and did not include pregnant subjects. Furthermore, reports that provided reviews on guidelines but did not contain specific recommendations were excluded, as well as guidelines that were developed before 2000 or that had not been updated in the last 10 years.
Two reviewers independently assessed the quality of the guidelines by using the English version of the AGREE instrument . The AGREE instrument consists of 23 items in six domains (Table 1), which includes: 1) scope and purpose of the guideline, 2) stakeholder involvement, 3) rigour of development, 4) clarity and presentation, 5) applicability and 6) editorial independence.
Each item was assessed on a 4-point scale: 1 = strongly disagree; 2 = disagree; 3 = agree and 4 = strongly agree. The additional information in the AGREE guide was used in order to clarify and correctly interpret each item. Differences between the scores on positive and negative assessment (e.g. scoring 1 or 2 vs. 3 or 4) of the two reviewers were resolved in a consensus meeting. Finally, domain scores were calculated by dividing the differences between the obtained score and the minimum possible score by the difference between the maximum possible score and the minimum possible score. In line with similar studies, we defined scores of 50% or less as low quality [13, 14].
Comparison of guidelines
Two reviewers individually summarized four guidelines each. Focus of the summaries was on recommendations. Each summary was checked by the other reviewer on clarity and completeness. One reviewer independently compared the recommendations of all summaries and the other reviewer examined if these comparisons were correct.
Four guidelines were identified in PubMed, four in the Guideline Clearing House and seven in Google. Guidelines were excluded for different reasons; the guideline of the International Diabetes Center  was excluded because this guideline was similar to the guideline of the American Diabetes Association [16, 17]. Other guidelines were excluded because they did not concern Western populations , did not focus on diabetes in pregnancy [19, 20] or because of publication date [21, 22].
Eight guidelines were included in this study, namely:
American College of Obstetricians and Gynecologists (ACOG) 
Colorado Clinical Guidelines Collaborative (CCGC) 
Dutch Society of Obstetrics and Gynaecology (DSOG) 
International Diabetes Federation (IDF) 
National Institute for Clinical Excellence (NICE) 
There was a high level of agreement between the two independent reviewers. In general, the quality of most guidelines was questionable when using the AGREE instrument. The domains with the highest scores were applicability, clarity and presentation and scope and purpose. The domains editorial independence, stakeholder involvement and rigour of development had the lowest scores. The domain scores of each guideline are shown in Table 2.
The majority of the guidelines described their scope and purpose quite specific. Four guidelines adequately described both objectives and patient groups [16, 17, 29–31]. In the other guidelines description of objectives was incomplete [23–28]. Moreover, specific clinical questions were only provided by the NICE guideline .
Regarding stakeholder involvement, seven guidelines scored below 50%. Patients’ view and preferences were often not included in the development of the guideline. Moreover, the guidelines had not been piloted among target users, with the exception of the NICE guideline .
Seven guidelines had a low score on rigour of development. This was mainly because most guidelines did not describe explicitly how they had identified, selected and summarized the available evidence. Also information on updating was not reported adequately in most guidelines; only the NICE guideline  provided a procedure for updating.
In contrast, except for the guideline from the BCRCP [26, 27], all guidelines provided information on health benefits, side effects or adverse effects. In addition, most guidelines provided an explicit link between recommendations and evidence by references or a summary of the evidence. Only the CCGC guideline  did not provide adequate information on the relation between evidence and recommendation.
Regarding clarity and presentation, seven guidelines scored over 50%. Key recommendations were easily identifiable and different options for management were given. It should be noted that only the CCGC guideline  and NICE guideline  were supported with tools for application, such as a quick reference guide.
On applicability, five guidelines scored over 50%. All guidelines presented key review criteria for monitoring and/or audit purposes. Considerations on costs or additional resources were described by four guidelines [16, 17, 24, 25, 30, 31]. The guidelines of the DSOG , IDF  and NICE  also provided information on potential organizational barriers.
Regarding editorial independence, all eight guidelines scored at or below 50%. Five guidelines did not report anything on both independency of funding body and conflicts of interest [16, 17, 23–25, 28, 29]. The other three guidelines only fulfilled one of the two items [26, 27, 30, 31].
Comparison of recommendations on management of diabetes during pregnancy
The recommendations in the guidelines can be divided into four domains, namely screening for GDM, glycemic control, prenatal care and labour and preconception counselling for women with DM1 or 2. The similarities and differences between the different guidelines on each domain will be discussed.
The first domain is screening for GDM. The recommendations in this domain were inconsistent. Three guidelines recommended that all pregnant women should be screened [24, 25, 28, 30]. On the other hand, four guidelines recommended that only women with risk factors should be screened [16, 17, 26, 27, 29, 31]. However, some guidelines refined their recommendation. The ADIPS guideline [24, 25] stated that selective screening should be used when resources are limited. Furthermore, the IDF guideline  stated that when the effectiveness of selective screening is shown, this should be recommended.
Not all guidelines were explicit about what screening criteria to use and at what time the screening should take place. Regarding the screening criteria, two guidelines stated that the Coustan & Carpenter criteria should be used [26–28] and one guideline [24, 25] recommended modified WHO-criteria. Concerning the time of screening, the BCRCP guideline [26, 27] stated that it is not important to screen early while the CCGC guideline  distinguished between women with and without risk factors. Women with risk factors should be screened as early in pregnancy as possible. For women without risk factors, early screening is not necessary.
The second domain is glycemic control. All guidelines made similar recommendations such as, among others;
Use a multidisciplinary approach that is adjusted to the individual.
Primary strategy is focused on nutrition and physical activity.
When glucose levels remain too high, medication therapy should be started.
Insulin is the primary choice; the use of hypoglycaemic agents is discouraged.
Blood glucose should be self-monitored regularly and the importance of maintaining normal glucose levels should be emphasized.
The third domain is prenatal care and labour. Two recommendations were similar for most guidelines, namely; 1) extra fetal surveillance is not necessary unless there are complications and 2) during labour, it is important to maintain normal glucose values. Therefore, glucose values should be monitored regularly.
Some guidelines made additional recommendations. For example, the ADIPS guideline [24, 25] stated that after delivery, women with pre-existing DM should be monitored closely to find a new balance. Furthermore, some guidelines [16, 17, 23, 29–31] stated that during prenatal care there should be searched for possible complications.
However, there was one important difference between the guidelines. Four guidelines recommended that delivery should not take place before full term unless there are complications [23–28]. In contrast to this, three guidelines stated that delivery should be induced after approximately 38 weeks of gestation [16, 17, 29, 31]. The IDF guideline  did not make recommendations on this topic.
The last domain is preconception counselling for women with pre-existing DM. The recommendations in this domain were similar for most guidelines. The first recommendation was that all women with DM1 or 2 in reproductive age should receive counselling. This counselling should include information about the risks in pregnancies complicated by diabetes. Also the importance of normal glucose values before conception should be stressed [16, 17, 23–31]. Other recommendations in this domain discussed the use of medication. Medication that is used before conception, for example hypoglycaemic agents, should be evaluated to determine if it is safe during pregnancy [16, 17, 23–31]. In addition, it must be checked if there are any complications, such as retinopathy, present before conception [16, 17, 23, 29].
The use of clinical guidelines is likely to have a positive influence on the management of diabetes during pregnancy [1, 11]. This article provides an overview of the quality and content of clinical guidelines regarding the management of diabetes during pregnancy. We reviewed eight guidelines from six different countries. This study shows that the overall quality of these guidelines was low when using the AGREE instrument. Only two guidelines were found to be of moderate  or high quality . In general, the recommendations in several domains were similar except for screening for GDM and induction for delivery at term.
It is important that guidelines are of high quality. According to the AGREE instrument, most guidelines inadequately reported on editorial independence, stakeholder involvement and rigour of development. Especially the low score on rigour of development is concerning, because explicit descriptions of how the available evidence was identified and selected is essential for the development of valid and reliable evidence-based recommendations.
Also descriptions of the updating procedures of the guidelines were poor, although it is important to keep the recommendations based on the best available evidence. Regarding stakeholder involvement, it might be important that views and preferences of patients are taken under consideration and that guidelines are piloted among target groups. This may increase success of implementation and thereby improve the management of diabetes during pregnancy.
The low quality of most guidelines could be explained by the fact that the AGREE instrument was not used by the committees that were developing or updating the guidelines. Only the committee of the NICE guideline  used an instrument to asses the quality which is part of their rigorous, standardized procedures. The use of the AGREE instrument already showed to improve the quality of other guidelines, such as guidelines on the management of low back pain [14, 32].
It should be noted that the score on the AGREE instrument does not only depend on the methodological quality of the guideline, but also on the quality of reporting. It is possible that guidelines of high methodological quality score low on the AGREE instrument due to poor reporting. One should bear this in mind while interpreting the results of the current study. However, most guidelines were published years after the AGREE instrument was first published. One would assume that guideline developers are aware of the most up to date discussions and literature about quality of developing and quality of reporting guidelines.
Although there is some debate about using the AGREE instrument for assessing the quality of guidelines and about a 50% cut-off value, other papers on back pain and acute gastroenteritis have used this approach before[13, 14]. Obviously, if the quality criteria were stricter, then even fewer guidelines would be considered of good quality, as shown in Table 2.
Regarding the recommendations, there were some discrepancies between guidelines. These differences might be a result of lack of evidence or weak associations. For example, recommendations regarding screening on GDM in the guidelines diverged as was also found in other studies [33, 34]. This diversity might be caused by equivocal evidence on this topic in the period in which most guidelines were developed . Also consensus usually does not warrant similar recommendations because not only the available evidence but also other aspects such as costs, applicability, constitution of the guideline committee and ethical considerations influence recommendations.
Nonetheless, more variety between recommendations was expected because of the variety in health care systems, culture in various countries and the differences in membership of the guideline committees. Therefore, current scientific evidence on the management of diabetes seems to be appropriate to generalize conclusions to these different groups. Moreover, previous studies also showed that international guidelines were consistent in most of their recommendations, especially on preconceptive care in women with diabetes .
The similarities between the guidelines included in this study could partly be explained by the fact that they all have been developed between 2001 and 2010. Moreover, the recommendations of the ADA guideline [16, 17] and the CCGC guideline  were based mainly on the same literature. Also some references of the IDF guideline  were similar to those of the ADA [16, 17] and the NICE guideline . In addition, the recommendations of the guideline of the DSOG  were partially based on the NICE guideline .
The quality of most guidelines on the management of diabetes during pregnancy can be improved. A more systematic approach in the development and reporting of these guidelines is recommended. Extra attention for updating procedures is advised. Also involvement of different health care professionals and patients in the development and evaluation of guidelines is necessary to obtain successful implementation. In addition, more attention for piloting of guidelines is recommended. In order to obtain and evaluate the improvements as described above, the AGREE instrument can be a helpful tool.
However, guidelines of good quality do not ensure good quality of management in daily practice. Therefore, further research is important to develop efficient implementation strategies to increase appropriate uptake of guideline recommendations by health care professionals.
Details of ethics approval
Ethics approval was not needed for this systematic literature review.
No funding was received.
Tieu J, Middleton P, McPhee AJ, Crowther CA: Screening and subsequent management for gestational diabetes for improving maternal and infant health. Cochrane Database Syst Rev. 2010, 7: CD007222-
Solomon CG, Willett WC, Carey VJ, Rich-Edwards J, Hunter DJ, Colditz GA, Stampfer MJ, Speizer FE, Spiegelman D, Manson JE: A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA. 1997, 278: 1078-1083. 10.1001/jama.1997.03550130052036.
Sunsaneevithayakul P, Boriboohirunsarn D, Sutanthavibul A, Ruangvutilert P, Kanokpongsakdi S, Singkiratana D, Bunyawanichkul S: Risk factor-based selective screening program for gestational diabetes mellitus in Siriraj Hospital: result from clinical practice guideline. J Med Assoc Thai. 2003, 86: 708-714.
Mikola M, Hiilesmaa V, Halttunen M, Suhonen L, Tiitinen A: Obstetric outcome in women with polycystic ovarian syndrome. Hum Reprod. 2001, 16: 226-229.
Roscam-Abbing H, Elion-Gerritzen W, Brouwer C, Diamant M, Heine R, van Lith J, Schreuder M, Schutte M, de Valk H, Heringa M, Wiersma T, Daemers D, Oldenziel J, Flikweert S, Merkus J, Eskes M: NTVG. De standaard “Zwangerschap en kraamperiode” (eerste herziening) van het Nederlandse Huisartsen Genootschap. 2004, 148-
Diabetes mellitus and pregnancy. http://emedicine.medscape.com/article/127547-overview,
Diabetes Control and Complications Trials Research Group: Pregnancy outcomes in the Diabetes Control and Complications Trial. Am J Obstet Gynecol. 1996, 174: 1343-1353.
Boulot P, Chabbert-Buffet N, D’Ercole C, Floriot M, Fontaine P, Fournier A, Gillet JY, Gin H, Grandperret-Vauthier S, Geudj AM, Guionnet B, Hauguel-de-Mouzon S, Hieronimus S, Hoffet M, Jullien D, Lamotte MF, Lejeune V, Lepercq J, Lorenzi F, Mares P, Miton A, Penfornis A, Pfister B, Renard E, Rodier M, Roth P, Sery G-A, Timsit J, Valat AS, Vambergue A, Verier-Mine O: French multicentric survey of outcome of pregnancy in women with pregestational diabetes. Diabetes Care. 2003, 26: 2990-2993.
Farrell T, Neale L, Cundy T: Congenital anomalies in the offspring of women with type 1, type 2 and gestational diabetes. Diabet Med. 2002, 19: 322-326. 10.1046/j.1464-5491.2002.00700.x.
Esakoff TF, Cheng YW, Sparks TN, Caughey AB: The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Am J Obstet Gynecol. 2009, 200: 672-e1-4
Kinsley B: Achieving better outcomes in pregnancies complicated by type 1 and type 2 diabetes mellitus. Clin Ther. 2007, 29 (Suppl D): S153-S160.
AGREE Collaboration: Development and validation of an international appraisal instrument for assessing the quality of clinical practice guidelines: the AGREE project. Qual Saf Health Care. 2003, 12: 18-23.
Lo Vecchio A, Giannattasio A, Duggan C, De Masi S, Ortisi MT, Parola L, Guarino A: Evaluation of the quality of guidelines for acute gastroenteritis in children with the AGREE instrument. J Pediatr Gastroenterol Nutr. 2011, 52: 183-189. 10.1097/MPG.0b013e3181e233ac.
Bouwmeester W, van Enst A, van Tulder M: Quality of low back pain guidelines improved. Spine. 2009, 34: 2562-2567. 10.1097/BRS.0b013e3181b4d50d.
International Diabetes Center: Prevention, detection and treatment of diabetes in adults. Diabetes in pregnancy. 2007, 4
American Diabetes Association: Gestational diabetes mellitus. Diabetes Care. 2003, 26 (Suppl 1): S103-S105.
Kitzmiller JL, Block JM, Brown FM, Catalano PM, Conway DL, Coustan DR, Gunderson EP, Herman WH, Hoffman LD, Inturrisi M, Jovanovic LB, Kjos SI, Knopp RH, Montoro MN, Ogata ES, Paramsothy P, Reader DM, Rosenn BM, Thomas AM, Kirkman MS, American Diabetes Association: Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care. Diabetes Care. 2008, 31: 1060-1079. 10.2337/dc08-9020.
Seshiah V, Das AK, Balaji V, Joshi SR, Parikh MN, Gupta S, Diabetes in Pregnancy Study Group: Gestational diabetes mellitus--guidelines. J Assoc Physicians India. 2006, 54: 622-628.
Canadian Diabetes Association: Clinical practice guidelines for the prevention and management of diabetes in Canada. Canadian J Diabetes. 2008, 32 (suppl 1): S1-S201.
Rowbard H, Blonde L, Braithwaite S, Brett E, Cobin R, American Association of Clinical Endocrinologists: Medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract. 2007, 13: 1-68.
Lassmann-Vague V, Basdevant A, Cathelineau G, Fenichel P, Laborde D, Mouroux D, Pinget M, Tchobroutsky C, Unal D, Vambergue A: Pregnancy and contraception in the diabetic woman. Gestational diabetes. Recommendations of ALFEDIAM (French Language Association for the Study of Diabetes and Metabolic Diseases). Diabetes Metab. 1996, 22: 459-469.
National Diabetes Commission Singapore: Guidelines for the management of diabetes mellitus in Singapore. Singapore Med J. 1993, 34 (6 Suppl): S1-35.
American College of Obstetricians and Gynecologists: ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Number 60, March 2005. Pregestational diabetes mellitus. Obstet Gynecol. 2005, 105: 675-685. 10.1097/00006250-200503000-00049.
Gestational diabetes mellitus - management guidelines. http://ranzcog.edu.au/publications/statements/coll-end-statements/ADIPS-gdm-management-guidelines.pdf,
Consensus guidelines for the management of type 1 and type 2 diabetes in relation to pregnancy. http://adips.org/images/stories/documents/adips_pregdm_guidelines.pdf,
Obstetric guideline 10A Gestational Diabetes. http://www.perinatalservicesbc.ca/sites/bcrcp/files/Guidelines/Obstetrics/MasterGestationalDiabetesOctober.pdf,
Obstetric guideline 10B Diabetes mellitus and pregnancy type 1 & 2. http://www.perinatalservicesbc.ca/sites/bcrcp/files/Guidelines/Obstetrics/MasterDiabetesMellitusOctober.pdf,
Gestational diabetes. http://www.coloradoguidelines.org/guidelines/gestationaldiabetes.asp,
Diabetes mellitus and pregnancy. http://www.nvog-documenten.nl/richtlijn/item/pagina.php?id=27418&richtlijn_id=863,
Global guideline on pregnancy and diabetes. http://www.idf.org/webdata/docs/Pregnancy_EN_RTP.pdf,
Diabetes in pregnancy - management of diabetes and its complications from preconception to the postnatal period. http://www.nice.org.uk/nicemedia/live/11946/41320/41320.pdf,
van Tulder MW, Tuut M, Pennick V, Bombardier C, Assendelft WJJ: Quality of primary care guidelines for acute low back pain. Spine. 2004, 29: E357-362. 10.1097/01.brs.0000137056.64166.51.
Agarwal MM, Dhatt GS, Punnose J, Koster G: Gestational diabetes: dilemma caused by multiple international diagnostic criteria. Diabet Med. 2005, 22: 1731-1736. 10.1111/j.1464-5491.2005.01706.x.
Vogel N, Burnand B, Vial Y, Ruiz J, Paccaud F, Hohlfeld P: Screening for gestational diabetes: variation in guidelines. Eur J Obstet Gynecol Reprod Biol. 2000, 91: 29-36. 10.1016/S0301-2115(99)00248-1.
Waugh N, Royle P, Clar C, Henderson R, Cummins E, Hadden D, Lindsay R, Pearson D: Screening for hyperglycaemia in pregnancy: a rapid update for the National Screening Committee. Health Technol Assess. 2010, 14: 1-183.
Mahmud M, Mazza D: Preconception care of women with diabetes: a review of current guideline recommendations. BMC Womens Health. 2010, 10: 5-10.1186/1472-6874-10-5.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/12/58/prepub
The authors declare that they have no competing interests.
All authors have made substantial contributions and gave final approval of the conceptions, drafting, and final version of this manuscript. MG and NE contributed equally to the data collection, review of the guidelines, interpretation of the data and the writing of this manuscript. MT provided the idea for this project, supervised the procedures in the study and reviewed the drafts and final version of this manuscript in concert with MW. All authors have seen and approved the final version of the manuscript.
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Greuter, M.J., van Emmerik, N.M., Wouters, M.G. et al. Quality of guidelines on the management of diabetes in pregnancy: a systematic review. BMC Pregnancy Childbirth 12, 58 (2012). https://doi.org/10.1186/1471-2393-12-58
- Clinical guidelines
- Diabetes mellitus
- Gestational diabetes