Short sleep duration, complaints of vital exhaustion and perceived stress are prevalent among pregnant women with mood and anxiety disorders
© Qiu et al.; licensee BioMed Central Ltd. 2012
Received: 20 April 2012
Accepted: 1 October 2012
Published: 3 October 2012
Psychiatric disorders have been associated with sleep disorders in men and non-pregnant women, but little is known about sleep complaints and disorders among pregnant women with psychiatric disorders.
A cohort of 1,332 women was interviewed during early pregnancy. We ascertained psychiatric diagnosis status and collect information about sleep duration, daytime sleepiness, vital exhaustion and perceived stress. Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Approximately 5.1% of the cohort (n=68) reported having a physician-diagnosis of mood or anxiety disorder before interview. Compared with women without a psychiatric diagnosis, the multivariable-adjusted OR (95% CI) for short sleep duration in early pregnancy (≤6 hours) were 1.95 (1.03-3.69). The corresponding OR (95%CI) for long sleep duration (≥9 hours) during early pregnancy was 1.13 (0.63-2.03). Women with psychiatric disorders had an increased risk of vital exhaustion (OR=2.41; 95%CI 1.46-4.00) and elevated perceived stress (OR=3.33; 95%CI 1.89-5.88). Observed associations were more pronounced among overweight/obese women.
Women with a psychiatric disorder were more likely to report short sleep durations, vital exhaustion and elevated perceived stress. Prospective studies are needed to more thoroughly explore factors that mediate the apparent mood/anxiety-sleep comorbidity among pregnant women.
Sleep disturbance, a significant health issue among pregnant women, is associated with several adverse pregnancy outcomes including prolonged labor, increased cesarean section rates, preeclampsia, preterm birth and postpartum depression [1–6]. Available studies suggest that up to 25% of pregnant women report significant sleep disturbances in the first trimester, with rates climbing to nearly 75% by the third trimester . Pregnancy associated physiological and hormonal changes are known to contribute to increased prevalence and severity of sleep disturbance among pregnant women [7–10].
A substantial literature indicates that sleep disturbances and psychiatric disorders (e.g., mood and anxiety disorders) are closely related, with psychiatric disorders having considerable impacts on sleep quality [11–17]. Sleep disturbance is both a defining feature of depression diagnosis , and is a prodromal symptom of both new and recurrent depressive episodes [18, 19]. Mood and anxiety disorders are known to be prevalent among reproductive age and pregnant women with a figure of 12.4% (range: 10% - 25%) [20–22]. However, despite these observations, the information concerning the association of mood and anxiety disorders with sleep characteristics during pregnancy is relatively limited. We are aware of several studies that have assessed maternal early pregnancy sleep characteristics among depressed pregnant women [19, 23–28]. However, many of these studies did not account for potential confounding factors. To extend the literature, we assessed the relative risks of short and long sleep duration, as well as excessive daytime sleepiness, vital exhaustion and elevated perceived stress during early pregnancy among women with and without a history of physician diagnosed mood and anxiety disorders. We hypothesized that pregnant women with a history of physician diagnosed clinical mood or anxiety disorders were more likely than women with no such history to report shorter sleep durations, and to report higher frequencies of excessive daytime sleepiness, vital exhaustion and perceived stress.
Study Population and Setting
This analysis is based on data collected from a cohort of women attending prenatal care clinics affiliated with Swedish Medical Center in Seattle, Washington, USA. Eligible women started prenatal care before 20 weeks gestation, were 18 years of age or older, could speak and read English, and planned to deliver at the study hospital. Participants reported socio-demographic, behavioral, and health characteristics in a structured interview completed between 8–19 weeks (mean and standard deviation: 16.0±2.6) weeks gestation. After delivery, study personnel abstracted data from participants’ hospital labor and delivery medical records and clinic records. Between December 2003 and July 2006, 1,393 (82%) of 1,685 approached women consented to participate. We sequentially excluded 12 women with early pregnancy losses prior to the interview and 49 women who did not complete the interview. A total of 1,332 women remained for analysis. All study procedures were approved by the Institutional Review Board of Swedish Medical Center. All participants provided written informed consent.
Interviewer-administered questionnaires were completed by participants in the analytical population at a mean gestational age of 16 weeks. Characteristics measured using the questionnaire included maternal age, height, pre-pregnancy weight, reproductive and medical history including her history of psychiatric disorders, average nightly sleep duration during pregnancy, vital exhaustion during early pregnancy, and perceived stress during early pregnancy. Information pertaining to participants’ psychiatric diagnoses was derived from self-reported medical histories with verification of diagnoses in medical records. Medical records included information about type of psychiatric disorder (e.g., depression, bipolar disorder, or anxiety disorders) and the timing of diagnosis. A total of 68 women were identified as having a diagnosis of a psychiatric disorder in this cohort. Sixty of these women had the diagnosis prior to the index pregnancy; the remaining 8 women had the diagnosis made during the first 20 weeks of the index pregnancy. No participant reported having bi-polar disorder. Fifty-seven of the sixty women with psychiatric disorders diagnosed before pregnancy reported using psychotropic medications during pregnancy. Seven of the 8 women with psychiatric diagnoses made in early pregnancy reported taking psychotropic medications in early pregnancy.
Maternal average nightly sleep duration during early pregnancy was ascertained by asking women the following question: “Since becoming pregnant, how many hours per night do you sleep?” Responses were reported as integers. We classified participants as short (≤ 6hours); normal (7–8 hours); and long (≥ 9 hours) duration sleepers. These categorizations were decided upon a priori, as decisions were guided by cut-points used by previously investigators, particularly those who focused on sleep problems among pregnant women .
Maternal report of vital exhaustion in early pregnancy was ascertained by asking participants the following question: “Since becoming pregnant, how often did you experience a sense of exhaustion (except after exercise)?” Response choices were: (1) never; (2) somewhat infrequently (about once monthly); (3) frequent (2–3 times per month); and (4) very frequent (almost weekly). For multivariable analyses, we collapsed responses into a dichotomous variable with “no” comprising the responses never and somewhat infrequently, and “yes” comprising the responses frequent and very frequent.
We used the Epworth Sleepiness Scale (ESS)  to assess maternal daytime sleepiness status during early pregnancy. Participants were asked to rate, on a scale of 0 to 3 (where 0=would never doze; 1=slight chance of dozing; 2=moderate chance of dozing; and 3=high chance of dozing), the likelihood they would fall asleep or doze off in each of the following eight common situations: sitting and reading; watching television; sitting, inactive in a public place (e.g., a theater or meeting); as a passenger in a car for an hour without a break; lying down to rest in the afternoon when circumstances permit; sitting and talking to someone; sitting quietly after lunch without alcohol; and in a car, while stopped for a few minutes in traffic. The scale yields a total score that ranges from 0 to 24, with higher ESS scores representing more severe subjective daytime sleepiness, respectively. Scores of 0–9, 10–12 and 13–24 are considered to represent normal, borderline and abnormal daytime sleepiness. For multivariable analyses, we created a dichotomous variable where participants with scores of ≥13 were classified as having excessive daytime sleepiness.
We used a modified abbreviated version of the Perceived Stress Scale (PSS), to measure the subjective experiences of stress and coping with stress using the past three month as timeframe. This timeframe corresponds to the time period since becoming pregnant (i.e., the first trimester). The abbreviated version, an economical and simple psychological instrument to administer, measures the degree to which situations in participants’ life over the period of observation are appraised as stressful . Items were selected to detect how unpredictable, uncontrollable, and overloaded participants find their lives. For multivariate analyses, we classified participants with scores ≥7 as having elevated perceived stress; those participants with scores <7 served as the reference group.
Characteristics of the study population: according to a medical history of mood/anxiety disorder, Seattle and Tacoma, Washington, USA, 2003-2006
Physician diagnosed mood/anxiety
Maternal Age (years)
34.2 ± 4.91
33.3 ± 4.41
Maternal Age (years)
Non-Hispanic white race/ethnicity
Annual household income (US$)*
High school or less education
Pre-gestational chronic hypertensive
Family history of diabetes mellitus
Family history of hypertension
Employed during pregnancy
Smoked during pregnancy*
No prenatal vitamin
No exercise during pregnancy
Pre-pregnancy body mass index (kg/m2)
24.1 ± 4.91
23.5 ± 4.61
Pre-pregnancy body mass index (kg/m2)*
All analyses were performed using Stata 9.0 statistical software (Stata, College Station, TX). All continuous variables are presented as mean ± standard deviation (SD). All reported confidence intervals were calculated at the 95% level. All reported p-values are two-tailed.
Sleep complaints reported by pregnant women: with and without a medical history of mood/anxiety disorder, Seattle and Tacoma, Washington, USA, 2003-2006
Physician diagnosed mood/anxiety
Mean ± SD or %
Mean ± SD or %
Sleep hours during pregnancy (hours)
7.6 ± 1.7
7.8 ± 1.3
Epworth sleepiness scale during pregnancy (score)
8.0 ± 3.4
7.6 ± 3.4
Vital exhaustion during pregnancy
Perceived stress scale (score)
5.1 ± 2.5
3.8 ± 2.3
Odds ratios (OR) and 95% confidence intervals (CI) of sleep complaints: according to medical history of mood/anxiety disorders, Seattle and Tacoma, Washington, USA, 2003-2006
Physician diagnosed mood/anxiety diagnosis
OR (95% CI)
OR (95% CI)
Sleep duration during pregnancy
Short (≤6 hours)
Normal (7–8 hours)
Long (≥9 hours)
Excessive daytime sleepiness during pregnancy
Vital exhaustion during pregnancy
Elevated perceived stress score (≥7) during pregnancy
Interaction of mood/anxiety and pre-pregnancy overweight status: adjusted odds ratios (AOR) and 95% confidence intervals (CI) of sleep complaints according to maternal history of mood/anxiety disorder and pre-pregnancy overweight status ** , Seattle and Tacoma, Washington, USA, 2003-2006
AOR (95% CI)
AOR (95% CI)
AOR (95% CI)
AOR (95% CI)
Sleep duration during pregnancy
Short (≤6 hours)
Long (≥9 hours)
Excessive daytime sleepiness during pregnancy
Vital exhaustion during pregnancy
Elevated perceived stress during pregnancy
Approximately 5.1% of the cohort reported having a medical diagnosis of mood or anxiety disorder. Overall, women with a positive history of a psychiatric disorder were more likely than others to report short sleep durations, vital exhaustion and elevated perceived stress. The odds of these complaints were particularly elevated among overweight/obese women.
Substantial studies, generally conducted in men and non-pregnant women [11–13, 15, 17] or children [14, 16] have examined one or more aspects of the mood or anxiety disorder-sleep comorbidity spectrum agree on our conclusion. Overall, our observations of higher odds of reported short sleep duration, excessive daytime fatigue, vital exhaustion and stress in pregnant women with a history of mood and anxiety disorder are consistent with previous studies. Our results are also largely consistent with reports from earlier studies that have documented increased prevalence of sleep disorders, stress or fatigue among pregnant women with mood or anxiety disorders [23–25, 27, 28]. A summary of findings from prior studies are presented in Additional file 1 (Table). For instance, our observation of positive associations of short sleep duration with mood or anxiety disorder is consistent with reports from Field et al.  who evaluated the effect of depression on self-report measures of sleep disturbance among 253 pregnant women at approximately 22 and 32 weeks gestation. The authors noted that those who were classified as depressed (using Structured Clinical Interview for DSM-IV (SCID)) were more likely to report sleep disturbances compared with non-depressed ones. Field et al. , later in a larger study among 911 pregnant women who were predominantly from low and medium socioeconomic status, replicated the same finding. In both studies the psychiatric diagnoses were made by research associates who used the SCID diagnostic instrument and who were supervised by a clinical psychologist. Okun et al.  in their secondary data analyses study, compared sleep disturbances in depressed (N=59) and non-depressed (N=181) pregnant women. Depression was ascertained using the SCID instrument at 20 weeks of gestation and sleep variables were extracted from the Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement (SIGH-ADS) at 20, 30, and 36 weeks gestation. The authors found that depressed women had more fragmented sleep at each assessment (p values<0.05). However, sleep deprivation, as reflected by percentage of total sleep duration <7 hrs (39.0% vs. 21.5%, p=0.008) and insomnia symptoms (55.9% vs. 30.4%, p=0.0004), was greater for depressed women only at 20 weeks gestation compared with non-depressed ones. Given that the sleep variables used in this study were imbedded within the SIGH-ADS depression screening scale, and thus were considered in making the psychiatric diagnosis, it is difficult to discern if observed correlations are independent of intrinsic measures of depression.
Overall, findings from the earlier studies provide some objective evidence on the relation between mood or anxiety disorders and sleep disturbances. However, methodological limitations including not controlling for confounding factors, small sample size, and lack of clinical diagnosis of mood/anxiety disorders did not allow one to draw firm conclusions to be made. Overcoming some of the noted methodological limitations of prior studies, our study adds to the body of evidence evaluating the impact of a clinically-diagnosed mood or anxiety disorders on sleep during early pregnancy. However, our results and those of others [23–25, 27, 28] are inconsistent with a report by Skouteris et al. . Their results showed that depressive symptoms earlier in pregnancy did not impact sleep quality at a later stage in pregnancy.
Our observation of higher perceived stress score in women with mood/anxiety disorders are in agreement with previous literature . Salacz and his colleagues found high Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores were associated with high levels of perceived stress (PSS score) in pregnancy women. A multiple regression analysis revealed that subjective feelings of stress explained over 50% of the variation in BDI and STAI scores .
Investigators speculated that common underlying pathophysiological neuroendocrine alterations involving the hypothalamus, serotonin and melatonin synthesis and secretion may, in part, explain consistent observations of increased risks of sleep disturbance in patients with mood and anxiety disorders. This hypothesis is supported by results from clinical [26, 33–35] and functional neuroendocrine imaging studies [36, 37]. Investigators have documented plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression . Moreover, investigators have reported lower plasma melatonin concentrations in patients with insomnia . Melatonin is known to play a role in the biological regulation of circadian rhythms and sleep. Both animal and human studies demonstrated agomelatine (a melatonin analogue drug acting as melatonin agonist and 5-HT antagonist) to be an effective treatment for depression and bipolar disorder [34, 35]. Serotonin secreted from the dorsal raphe nuclei is implicated in both the control of mood and anxiety disorder pathogenesis and sleep cycles . The suprachiasmatic nucleus of the hypothalamus regulates the release of serotonin, supporting the thesis that the hypothalamus likely plays an important role in both the control of mood and sleep-regulating systems. Increased hypothalamic-pituitary-adrenal (HPA) activity, a robust pathophysiological biomarker associated with mood/anxiety disorders , is regarded as one important mechanism for observed associations between maternal psychiatric illness and perceived stress level .
Several limitations of our study merit discussion and consideration. First, the prevalence of mood/anxiety disorder of 5.1% in this sample is well below the national prevalence estimate reported by other investigators [21, 22]. As a result, it is likely that a considerable number of women with psychiatric illnesses were misclassified as not having mood or anxiety disorder in our cohort. This under-ascertainment of psychiatric illnesses would generally serve to underestimate the true magnitude of associations detected in our study. Second, we did not collect information on onset of psychiatric symptoms, nor did we collection on the precise date of diagnosis. We were, however, able to distinguish women who had a recent diagnosis made prior to the study pregnancy or during the first 20 weeks of the index. We did not collect information of the effectiveness of the treatment. Third, maternal habitual sleep duration during pregnancy was obtained from self-report, and thus is likely susceptible to misclassification. Reported sleep duration is known to be only moderately correlated with wrist actigraph-measured sleep duration (r=0.47), and reports are generally longer by approximately 34 minutes for each hour of objectively measured sleep duration . Future studies will require making objective assessments of maternal sleep duration. Fourth, we did not have information concerning participants’ shift-work or insomnia status and thus cannot attribute observed associations of short sleep duration with psychiatric disorders to occupational or medical conditions associated with short sleep duration. For instance, though related, short sleep duration and insomnia are different entities. Insomnia entails dissatisfaction with the quality of sleep and an inability to sleep given adequate opportunity. Insomnia can result in short sleep duration, but individuals with short sleep duration do not necessarily suffer from insomnia (i.e., participants may sleep less because they choose to do so or because they lack the opportunity to sleep). Future studies that allow for the comprehensive ascertainment of maternal sleep disorders (e.g., sleep disordered breathing, restless legs syndrome, insomnia, and circadian rhythm disorders) will be needed to more thoroughly assess the co-morbidity of psychiatric illnesses and sleep disorders among pregnant women. Fifth, although we adjusted for several potential confounders, we cannot exclude the possibility of residual confounding due to misclassification of adjusted variables (e.g., maternal pre-pregnancy body mass index) or confounding by other unmeasured variables (e.g., maternal exposure to the shift work during pregnancy). In consideration of evidence suggesting that adiposity may be associated with both psychiatric illnesses and sleep disorders , we report results from models which allow for assessing the independent and joint effects of psychiatric diagnoses and overweight status on each sleep complaint variable. The amount of sleep has declined by 1.5 hours over the past century, accompanied by an important increase in obesity . Lastly, the generalizability of our study may also be limited as our cohort was primarily comprised of Non-Hispanic White and well-educated women. The concordance of our results with those from other studies that have included racially, ethnically and geographically diverse populations [23–25, 27, 28], however, serve to attenuate these concerns.
We found increased odds of short sleep duration, vital exhaustion and perceived stress among pregnant women with mood or anxiety disorders compared with pregnant women without such disorders. These associations were particularly strong among overweight/obese women with psychiatric illnesses. Despite noted study limitations, our results are consistent with a larger body of work documenting associations between psychiatric disorders and sleep disturbances in men, non-pregnant women and children. Large well designed prospective cohort studies that allow for the comprehensive examination of comorbidity of the full spectrum of severity of psychiatric illnesses (e.g., isolated mood disorders, isolated generalized anxiety disorders, post-traumatic stress disorder, co-morbid mood and anxiety disorders) and the full spectrum of sleep disorders in pregnant women are warranted. Such studies should include objective assessments of sleep duration and disorders and should include comprehensive assessments of environmental, behavioral, and genetic risk factors of maternal antepartum and postpartum psychiatric health. Enhanced understanding of the epidemiology and shared pathophysiological mechanisms between psychiatric illnesses and sleep disturbances are expected to provide important information needed for enhancing the diagnosis and treatment of these disorders in pregnant women.
This research was supported by awards from the National Institutes of Health (R01HD-055566 and R01HD-32562). This research was completed while Dr. Neway Fida was a Postdoctoral Research Fellow with the University of Washington Reproductive, Perinatal and Pediatric Research Training Program supported by an award from the from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, (T32 HD052462). The authors are indebted to the staff of the Center for Perinatal Studies for their expert technical assistance.
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