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Table 1 The precise criteria used to stratify the evidence of studies examining maternal risk factors for Low Birth Weight

From: The maternal factors associated with infant low birth weight: an umbrella review

Evidence

Criteria

factors

Convincing evidence (Class I)

number of cases > 1000

p-value of the meta-analysis < 10− 6

I² < 50%

95% prediction interval excluding the null

p-value of the egger test > 0.05 and p-value of the Ioannidis test > 0.05

Crack/cocaine

Infertility

Highly suggestive (Class II)

number of cases > 1000

p-value of the meta-analysis < 10− 6

largest study with a statistically significant effect

and class I criteria were not met

antenatal Care

smoking

Suggestive (Class III)

number of cases > 1000

p-value of the meta-analysis < 10− 3

and class I–II criteria not met

caffeine/coffee

anemia

Depression

Periodontal disease

Weak (Class IV)

p-value of the meta-analysis < 0.05

and class I–III criteria not met

heavy physical workload

underweight

heavy lifting

alcohol

hypothyroidism

Hypertension

Non-significant

Associations (NS)

p-value of the meta-analysis > = 0.05

overweight/obesity