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Table 1 Characteristics of the included studies in the meta-analysis

From: Systematic review and meta-analysis on the effect of adjuvant gonadotropin-releasing hormone agonist (GnRH-a) on pregnancy outcomes in women with endometriosis following conservative surgery

Study

Country

Jadad score

GnRH-a group

Control group

Sample size

Time of

Therapy

Follow-up

Outcomea

conception way

Saeed Alborzi 2010 [37]

Iran

5

Triptorelin 3.75 mg

Without GnRH-a/

Letrozole

40/57

/47

2 M

12 M

afg

unclear

Ibrahim Alkatout 2012 [46]

Germany

5

Leuprorelin

3.75 mg

Without GnRH-a

148/137

3 M

2Y

abcd

unclear

Piyush Bansal 2018 [47]

India

7

Leuprodex 3.75 mg

Without GnRH-a

41/42

1 M

2 Y + 6 M

ab

SO + IUI

M.Busacca 2001 [38]

Italy

5

Leuprolide

3.75 mg

Without GnRH-a

44/45

3 M

6-36 M

ah

unclear

Marcello Ceccaroni 2021 [41]

Italy

3

Triptorelin/

Leuprorelin

3.75 mg

Dienogest

81/65

6 M

30 ± 6 M

abh

ART/spontaneously

W. Decleer 2016 [54]

Belgium

6

GnRH-a

Without GnRH-a

61/58

3 M

unclear

a

ART

Haiyan Guo 2022 [51]

China

5

GnRH-a

Medroxyprogesterone

150/150

1 M

unclear

abcde

ART

Giuseppe Loverro 2006 [43]

Italy

3

Triptorelin

3.75 mg

Without GnRH-a

29/25

3 M

5Y

ag

spontaneously

Recai Pabuccu 2007 [52]

Turkey

5

GnRH-a

GnRH-ant

48/50

1 M

unclear

ac

ART

Dagmar Rickes 2002 [49]

Germany

5

Goserelin

3.6 mg

Without GnRH-a

55/55

6 M

4 w

a

ART

Elisabet Rodr´ıguez-Tarrega 2020 [42]

Italy

7

Triptorelin

3.75 mg

placebo

91/92

3 M

unclear

abcde

ART

Eric S. Surrey 2002 [48]

California

5

Leuprolide

3.75 mg

Without GnRH-a

25/26

3 M

unclear

af

ART

Paolo Vercellini 1999 [50]

Italy

5

Goserelin

3.6 mg

Without GnRH-a

107/103

6 M

2Y

ag

unclear

Huiling Xue 2018 [44]

China

4

Triptorelin

3.75 mg

Gestrinone/

Mifepristone

50/50

/50

3 M

2Y

abcdgh

unclear

Xin-hua Yang 2014 [36]

China

2

Goserelin

(Zoladex)

3.6 mg

Without GnRH-a

63/62

3 M

18 M

afg

spontaneously

Yu Yang 2019 [45]

China

2

Triptorelin

3.75 mg

Without GnRH-a

65/65

6 M

2Y

agh

unclear

ZHAO Rui-hua 2012 [53]

China

2

GnRH-a

3.75 mg

CM

102/106

6 M (stage I-II:3 M)

20.66 ± 6.75/20.83 ± 6.65 M

afgh

unclear

  1. a a: pregnancy rate, b: live birth rate, c: miscarriage rate, d: ectopic pregnancy rate, e: multiple pregnancy rate, f: the mean interval from surgery to pregnancy, g: recurrence rate, h: adverse reactions rate