Transition of the genital mollicutes from the second to the third trimester of pregnancy and its association with adverse pregnancy outcomes in GDM women: a prospective, single-center cohort study from China

Table 4 Association of different genital Mollicutes infection statuses in the second and the third trimester with premature rupture of membrane, fetal distress macrosomia and other adverse pregnancy outcomes

Outcomes	N	No. of events	%	Crude Model		Model A
Outcomes	N	No. of events	%	OR	95% CI	OR	95% CI
Premature rupture of membrane
(-/-)	191	43	22.51	1.00		1.00
(+/-)	65	14	21.54	0.94	(0.47, 1.83)	1.05	(0.51, 2.08)
(-/+)	95	21	22.11	0.98	(0.53, 1.75)	0.87	(0.46, 1.59)
(+/+)	81	20	24.69	1.13	(0.61, 2.06)	0.99	(0.53, 1.82)
Fetal distress
(-/-)	191	10	5.24	1.00		1.00
(+/-)	65	4	6.15	1.19	(0.32, 3.69)	1.21	(0.31, 3.91)
(-/+)	95	4	4.21	0.80	(0.21, 2.45)	0.69	(0.18, 2.19)
(+/+)	81	2	2.47	0.46	(0.07, 1.79)	0.40	(0.06, 1.58)
Macrosomia
(-/-)	191	8	4.19	1.00		1.00
(+/-)	65	2	3.08	0.73	(0.11, 2.99)	0.72	(0.11, 2.98)
(-/+)	95	2	2.11	0.49	(0.07, 2.01)	0.55	(0.08, 2.26)
(+/+)	81	1	1.23	0.29	(0.02, 1.60)	0.29	(0.02, 1.65)
Others
(-/-)	191	25	13.09	1.00		1.00
(+/-)	65	3	4.62	0.32	(0.07, 0.96)	0.33	(0.08, 1.00)
(-/+)	95	10	10.53	0.78	(0.34, 1.66)	0.68	(0.29, 1.48)
(+/+)	81	5	6.17	0.44	(0.14, 1.10)	0.41	(0.13, 1.04)

N is the total number in this category. No. of events is the number in the category with the outcome, and % is the proportion in the category with the outcome. Participants were grouped based on the second and third trimester infection status as: uninfected in either trimester (-/-), merely infected in the second trimester (+/-), merely infected in the third trimester (-/+), infected in both trimesters (+/+). Model A was adjusted for tobacco exposure and alcohol intake

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