Impact of thyroid autoimmunity on the cumulative live birth rates after IVF/ICSI treatment cycles

Table 4 Subgroup analysis of cumulative live birth outcomes according to different types of thyroid antibodies

Group	No. of patients	No. of LB	CLBR (%) ^a	OR (95%CI)	Adjusted OR (95%) ^*
Co-positive for TGAb and TPOAb	1244	630	50.6	0.94 (0.84–1.06)	0.99 (0.87–1.12)
Isolated positive for TGAb	779	400	51.3	0.97 (0.84–1.12)	0.98 (0.84–1.14)
Isolated positive for TPOAb	580	286	49.3	0.89 (0.76–1.06)	0.93 (0.78–1.11)
Co-negative for TGAb and TPOAb	10,193	5316	52.2	1	1

TGAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; LB, live birth; CLBR, cumulative live birth rate; OR, odds ratio
^a CLBR: cumulative live birth was defined as the delivery of one or more living infants in the first and subsequent frozen-thawed cycles. The cumulative live birth rate was calculated as the number of cumulative live births divided by the number of COS cycles
^* The multivariate model was adjusted for age, body mass index, cause of infertility, FT4, TSH, COS protocols, type of transfer (fresh vs. frozen), type of transferred embryo (cleavage-stage embryo vs. blastocyst), and fertilization method (IVF vs. ICSI).

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