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Table 4 Results from logistic regression analyses of histologic chorioamnionitis, maternal inflammatory responsea according to maternal and pregnancy characteristics in a prospective observational study of 315 singleton term placentas meeting the criteria for referral to histopathologic examination

From: Placental pathology and neonatal morbidity: exploring the impact of gestational age at birth

 

Histologic chorioamnionitis, maternal inflammatory response

 

Unadjusted models

Adjusted modelb

 

Characteristics

OR

95% CI

p-value

OR

95% CI

p-value

 

Mother not born in Norway

1.24

(0.49, 3.18)

0.658

    

Maternal age ≥ 35 years

0.72

(0.34, 1.52)

0.377

    

BMI ≥ 30 (kg/m²)

0.92

(0.33, 2.53)

0.871

    

Smoking

2.00

(0.52, 7.68)

0.340

    

Primiparity

2.86

(1.36, 5.99)

0.003

2.22

(1.01, 4.86)

0.039

 

Preeclampsia

0.51

(0.21, 1.26)

0.122

    

Severe preeclampsiac

0.23

(0.03, 1.72)

0.073

    

Clinical chorioamnionitis

11.76

(4.28, 32.33)

< 0.001

5.97

(1.99, 17.91)

0.001

 

Pregestational diabetes

0.48

(0.06, 3.75)

0.436

    

Gestational diabetes

2.07

(0.71, 5.99)

0.206

    

PROM

1.89

(0.50, 7.18)

0.374

    

Emergency section

3.19

(1.68, 6.05)

< 0.001

2.05

(1.01, 4.15)

0.049

 

SGA < 5 percentile

0.55

(0.24, 1.29)

0.150

    

LGA > 90 percentile

1.61

(0.51, 5.09)

0.434

    

Male sex

1.35

(0.72, 2.54)

0.352

    

Gestation weekd

1.60

(1.27, 2.03)

< 0.001

1.45

(1.13, 1.87)

0.003

 
  1. Abbreviations: OR = odds ratio; CI = confidence interval; BMI = body mass index; PROM = prelabour rupture of membranes; SGA = small for gestational age; LGA = large for gestational age; HELLP = hemolysis, elevated liver enzymes, low platelets
  2. aDichotomised into no response/maternal stage 1 versus maternal stage 2 or 3, bIncludes all characteristics significant at 5% level in the unadjusted models, cIncluding HELLP syndrome and eclampsia, dAs continuous variable