Table 4 Crude and adjusted Odds ratios for adverse perinatal outcomes according to COVID-19 vaccination trimester

Preterm birth

unvaccinated

112,003

9,151(8.17)

Baseline

First trimester

1,202

134(11.15)

1.41(1.17 to 1.68)

<0.001

1.27(1.04 to 1.55)

0.01

Second trimester

10,250

896(8.74)

1.07(1.00 to 1.15)

0.04

1.00(0.93 to 1.08)

0.85

Third trimester

6,033

366(6.07)

0.72(0.65 to 0.80)

<0.001

0.68(0.61 to 0.77)

<0.001

Extremely preterm birth

unvaccinated

112,003

1,497(1.34)

Baseline

First trimester

1,202

13(1.08)

0.80(0.46 to 1.39)

0.44

0.77(0.43 to 1.38)

0.39

Second trimester

10,250

105(1.02)

0.76(0.62 to 0.93)

0.008

0.72(0.58 to 0.90)

0.004

Third trimester

6,033

15(0.25)

0.18(0.11 to 0.30)

<0.001

0.20(0.12 to 0.33)

<0.001

Congenital anomaly

unvaccinated

112,003

382(0.34)

Baseline

First trimester

1,202

6(0.50)

1.46(0.65 to 3.29)

0.35

1.50(0.66 to 3.38)

0.32

Second trimester

10,250

45(0.44)

1.28(0.94 to 1.75)

0.10

1.21(0.87 to 1.68)

0.23

Third trimester

6,033

13(0.22)

0.63(0.36 to 1.09)

0.10

0.55(0.30 to 1.01)

0.05

stillbirth

unvaccinated

112,003

815(0.73)

Baseline

First trimester

1,202

10(0.83)

1,14(0.61 to 2.14)

0.67

1,09(0.58 to 2.06)

0.76

Second trimester

10,250

64(0.62)

0.85(0.66 to 1.10)

0.23

0.74(0.56 to 0.98)

0.03

Third trimester

6,033

16(0.27)

0.36(0.22 to 0.59)

<0.001

0.25(0.13 to 0.46)

<0.001

Intrauterine growth restriction

unvaccinated

112,003

2,169(1.94)

Baseline

First trimester

1,202

30(2.50)

1,29(0.89 to 1.86)

0.16

1.37(0.93 to 2.02)

0.10

Second trimester

10,250

202(1.97)

1.01(0.88 to 1.17)

0.81

1.00(0.86 to 1.17)

0.91

Third trimester

6,033

115(1.91)

0.98(0.81 to 1.18)

0.86

1.05(0.86 to 1.28)

0.59

Low birth weight

unvaccinated

112,003

7,007(6.26)

Baseline

First trimester

1,202

98(8.15)

1.33(1.08 to 1.63)

0.007

1.27(0.96 to 1.67)

0.09

Second trimester

10,250

639(6.23)

0.99(0.91 to 1.08)

0.93

0.99(0.88 to 1.11)

0.89

Third trimester

6,033

280(4.64)

0.72(0.64 to 0.82)

0.001

1.11(0.96 to 1.28)

0.15

Very low birth weight

unvaccinated

112,003

1,468(1.31)

Baseline

First trimester

1,202

17(1.41)

1.08(0.66 to 1.74)

0.75

1.80(0.82 to 3.92)

0.13

Second trimester

10,250

106(1.03)

0.78(0.64 to 0.95)

0.01

0.90(0.64 to 1.28)

0.57

Third trimester

6,033

22(0.36)

0.27(0.18 to 0.42)

<0.001

1.10(0.65 to 1.87)

0.70

NICU admission

unvaccinated

112,003

11,348(10.13)

Baseline

First trimester

1,202

148(12.31)

1.24(1.04 to 1.48)

0.01

1.15(0.94 to 1.40)

0.15

Second trimester

10,250

1,057(10.31)

1.01(0.95 to 1.09)

0.56

1.01(0.94 to 1.09)

0.62

Third trimester

6,033

557(9.23)

0.90(0.82 to 0.98)

0.02

0.95(0.86 to 1.05)

0.38

Low 5-minute Apgar score

unvaccinated

112,003

1,341(1.20)

Baseline

First trimester

1,202

15(1.25)

1.04(0.62 to 1.74)

0.87

1.04(0.50 to 2.16)

0.90

Second trimester

10,250

110(1.07)

0.89(0.73 to 1.08)

0.26

1.04(0.80 to 1.36)

0.73

Third trimester

6,033

28(0.46)

0.38(0.26 to 0.55)

<0.001

0.80(0.51 to 1.27)

0.36

Neonatal death

unvaccinated

112,003

146(0.13)

Baseline

First trimester

1,202

2(0.17)

1.27(0.31 to 5.1)

0.73

1.34(0.29 to 6.03)

0.70

Second trimester

10,250

11(0.11)

0.82(0.44 to 1.51)

0.53

1.25(0.66 to 2.39)

0.48

Third trimester

6,033

2(0.03)

0.25(0.06 to 1.02)

0.05

0.36(0.04 to 2.65)

0.31