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Table 3 Association of NVP with genomic loci meeting significance thresholds at the replication stage

From: Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study

       

Discovery stage (JPA NEO)

 

Replication stage (JPAv2)

 

Meta-analysis

Cytoband

Sentinel SNP

Position (hg19)

Gene

Function

Ref

Alt

AF1

β (SE)

p-value

 

AF1

β (SE)

p-value

 

p-value

Direction

Binary 2

                

 19p13.11

rs749451

19:18479647

PGPEP1

UTR3

T

C

0.49

0.184 (0.032)

8.04E-09

 

0.49

0.202 (0.031)

1.16E-10

 

5.546E-18

++

 8q21.3

rs149783780

8:90026699

-

-

CAAAA

CA

0.01

-0.042 (0.145)

7.73E-01

 

0.01

0.833 (0.145)

1.00E-08

 

8.95E-05

-+

 11q11

rs2867907

11:55170876

OR4A15, OR4C15

Intergenic

C

T

0.50

-0.017 (0.033)

6.09E-01

 

0.50

-0.178 (0.032)

3.87E-08

 

1.73.E-05

--

Binary 3

                

 4q25

rs75393668

4:108157443

DKK2, PAPSS1

Intergenic

T

C

0.91

0.121 (0.088)

1.69E-01

 

0.91

-0.542 (0.091)

2.80.E-09

 

8.96E-04

+-

Binary 4

                

 19p13.11

rs749451

19:18479647

PGPEP1

UTR3

T

C

0.50

0.312 (0.063)

6.17E-07

 

0.49

0.373 (0.064)

4.61E-09

 

1.80E-14

++

Continuous

                

 19p13.11

rs749451

19:18479647

PGPEP1

UTR3

T

C

0.49

0.084 (0.014)

5.97E-10

 

0.49

0.092 (0.013)

1.08E-12

 

4.42E-21

++

  1. AF1, allele 1 frequency; Alt, alternative allele; β, regression coefficient; JPA NEO, Axiom Japonica Array NEO; JPAv2, Axiom Japonica Array v2; NVP, nausea and vomiting of pregnancy; Ref, reference allele; SE, standard error, SNP, single nucleotide polymorphism; UTR, untranslated region
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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