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Table 2 Association of NVP with genomic loci meeting significance thresholds at the discovery stage

From: Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study

       

Discovery stage (JPA NEO)

 

Replication stage (JPAv2)

 

Meta-analysis

Cytoband

Sentinel SNP

Position (hg19)

Gene

Function

Ref

Alt

AF1

β (SE)

p-value

 

AF1

β (SE)

p-value

 

p-value

Direction

Binary 2

                

 19p13.11

rs749451

19:18479647

PGPEP1

UTR3

T

C

0.49

0.184 (0.032)

8.04E-09

 

0.49

0.202 (0.031)

1.16E-10

 

5.55E-18

+ +

Binary 4

                

 11q22.1

rs77775955

11:101247714

PGR-AS1, TRPC6

intergenic

G

A

0.56

−0.392 (0.063)

5.54E-10

 

0.53

−0.182 (0.064)

4.46E-03

 

1.42E-10

− −

Continuous

                

 11q22.1

rs77775955

11:101247714

PGR-AS1, TRPC6

intergenic

G

A

0.55

−0.090 (0.014)

3.89E-11

 

0.55

−0.046 (0.013)

4.11E-04

 

9.75E-13

− −

 19p13.11

rs28568614

19:18479019

PGPEP1

UTR3

A

G

0.49

0.085 (0.014)

4.54E-10

 

0.48

0.091 (0.013)

1.87E-12

 

5.66E-21

+ +

  1. AF1, allele 1 frequency; Alt, alternative allele; β, regression coefficient; JPA NEO, Axiom Japonica Array NEO; JPAv2, Axiom Japonica Array v2; NVP, nausea and vomiting of pregnancy; Ref, reference allele; SE, standard error, SNP, single nucleotide polymorphism; UTR, untranslated region
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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