Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study

Table 5 GMDR analysis for gene–gene and gene–phthalates exposure interaction models in CHDs

Model	Training Bal. Acc	Testing Bal. Acc	Sign Test (P-Value)	CV Consistency
Gene-gene interaction
rs4124874	0.5690	0.5691	10(0.0010)	10/10
rs1057910 rs4124874	0.5933	0.5397	8(0.0547)	5/10
rs4124874 rs3100 rs2045100 rs12233719	0.6565	0.5292	7(0.1719)	5/10
rs4244285 rs11692021 rs4124874 rs1902023 rs4587017	0.7091	0.4999	4(0.8281)	3/10
Gene-PAEs phthalates interaction
rs11692021 rs1902023 MEHP	0.6161	0.5186	7(0.1719)	3/10
rs4244285 rs11692021 rs4124874 rs1902023 rs12233719 MEHP	0.7740	0.4988	5(0.6230)	2/10
rs4244285 rs11692021 rs4124874 rs9994887 rs7662029 MiBP MEHP	0.8376	0.4832	5(0.6230)	3/10
rs4244285 rs11692021 rs4124874 rs9994887 rs7662029 rs12233719 MnBP MBzP	0.8912	0.5023	4(0.8281)	5/10
rs4244285 rs11692021 rs4124874 rs2045100 rs9994887 rs7662029 MiBP MEHP MCMHP	0.9361	0.4287	1(0.9990)	2/10

Notes Training Bal. Acc: training balanced accuracy; Testing Bal. Acc: testing balanced accuracy; CV Consistency: cross validation consistency

ISSN: 1471-2393