Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study

Table 2 R² and F-statistic results for the genetic variants that were genome wide significant in the original genome wide association study

Genetic variant (SNP) ID	Number of-participants	Minor allele frequency	Per allele difference (SDs of log-transformed units) in plasma cortisol (95% CI)	R²	F-Statistic
rs11620763	25314	0.19	0.09 (0.06 to 0.11)	0.0023	57.49
rs2736898	25314	0.49	0.06 (0.04 to 0.07)	0.0017	43.37
rs7146221	25314	0.45	0.05 (0.03 to 0.07)	0.0013	31.87
rs9989237^a	25314	0.21	0.09 (0.07 to 0.10)	0.0024	61.83

^aSNP used in main analysis
^bThe R² and F-statistics for rs11620763, rs2736898 and rs7146221 may be under or overestimated due to linkage disequilibrium with rs9989237

ISSN: 1471-2393