Table 1 Summary of studies contributing to a) the circulating cortisol GWAS (CORNET), b) the maternal effects on pregnancy GWAS (EGG) and c) the observational pregnancy circulating cortisol (EFSOCH)
From: Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study
a) | Study | Country | N | Age, years (SD) | Cortisol, nmol/l (SD) | Sampling time |
ORCADES | UK | 1974 | 53.5 (15.7) | 765 (315) | 0830-1030 | |
CROATIA-Korcula | Croatia | 898 | 56.2 (13.9) | 698 (207) | 0800-0900 | |
CROATIA-Split | Croatia | 496 | 45.0 (14.7) | 979 (404) | 0730-0900 | |
CROATIA-Vis | Croatia | 892 | 56.4 (15.5) | 622 (230) | 0730-0900 | |
Rotterdam Study | Netherlands | 6497 | 63.3 (9.6) | 359 (115) | 0800-1100 | |
HBCS1934-44 | Finland | 451 | 60.61 (2.80) | 393 (120) | 0750-1055 | |
NFBC1966 | Finland | 1324 | 31.1 (0.3) | 380 (160) | 0800-1100 | |
ALSPAC | UK | 1567 | 15.43 (0.26) | 486 (174) | 0800-1057 | |
PIVUS | Sweden | 919 | 70.2 (0.17) | 386 (125) | 0800-1000 | |
PREVEND | Netherlands | 1151 | 49.4 (13.0) | 442 (201) | 0800-1100 | |
ET2DS | UK | 1048 | 67.9 (4.2) | 731 (190) | 0800-0830 | |
Raine Study | Australia | 860 | 17.1 (0.29) | 614 (235) | Awakening (before 1000) | |
MrOS Sweden | Sweden | 969 | 75.3 (3.2) | 487 (133) | 0700-1000 | |
VIKING | UK | 2073 | 49.9 (15.2) | 292 (170) | 0800-1030 | |
SHIP | Germany | 910 | 49.8 (13.8) | * | Before 1300 | |
TwinsUK | UK | 5654 | 53.3 (13.8) | * | 0800-1200 | |
KORA | Germany | 1651 | 60.92 (8.7) | * | NA | |
b) | Study | Country | N | Age, years (SD) | Birthweight, g (SD) | Gestational age, weeks (IQR) |
UK Biobank | UK | 190,406 | 25.3 (4.5) | 3227 (477) | NA | |
B58C-WTCCC | UK | 858 | 26.2 (5.2) | 3325 (483) | 40 (40–41) | |
B58C-T1DGC | UK | 836 | 26.1 (5.4) | 3379 (469) | 40 (40–41) | |
DNBC-GOYA | Denmark | 1805 | 29.2 (4.2) | 3643 (495) | 40 (39–41) | |
DNBC-PTB-CONTROL | Denmark | 1656 | 29.9 (4.2) | 3595 (497) | 40 (39–40) | |
MoBa-2008 | Norway | 650 | 28.5 (3.3) | 3679 (430) | 40 (0.9) | |
NFBC1966 | Finland | 2035 | 26.5 (3.7) | 3525 (461) | 40 (2) | |
NTR | Netherlands | 707 | 27.1 (3.7) | 3469 (529) | 40 (38–42) | |
QIMR | Australia | 892 | 24.5 (4.0) | 3344 (532) | NA | |
TWINSUK | UK | 1603 | NA | NA | NA | |
ALSPAC | UK | 6,686 | 28.0 (5.0) | 3468 (475) | 40 (40–41) | |
HAPO | USA | 1280 | 31.5 (5.3) | 3557 (517) | 40 (1.7) | |
EFSOCH | UK | 855 | 30.5 (5.9) | 3506 (472) | 40 (37–43) | |
c) | Study | Country | N | Age, years (SD) | Cortisol, nmol/l (SD) | Sampling time |
EFSOCH | UK | 892 | 30.4 (5.3) | 1010 (234) | 0900 (within 60 minutes) |