Skip to main content

Table 3 Prediction of fluid responsiveness by receiver operating characteristic curves of the baseline VTI and CABF

From: Predicting fluid responsiveness in spontaneously breathing parturients undergoing caesarean section via carotid artery blood flow and velocity time integral measured by carotid ultrasound: a prospective cohort study

 

AUROC curve

(95% CI)

P-value

Optimal cut-off

value

Grey zone

Patients in grey zone (%)

Sensitivity (%)

(95% CI)

Specificity (%)

(95% CI)

Youden index

PPV (%)

(95%CI)

NPV (%)

(95%CI)

VTI

0.821

(0.720–0.922)

0.0003

8.7 cm/s

6.8–8.7 cm/s

13(18%)

67.0(50.1–86.0)

90.0

(80.0-100.0)

0.577

0.84

(0.68-1.00)

0.79

(0.66–0.91)

CABF

0.803

(0.701–0.905)

0.0001

175.9 ml/min

114.2-175.9

ml/min

29(40%)

74.0(57.0–91.0)

78.0

(64.0–92.0)

0.520

0.72

(0.55–0.89)

0.67

(0.67–0.93)

  1. VTI: carotid artery velocity time integral;CABF: carotid artery blood flow; AUROC: area under the receiver operating characteristic; CI, confidence interval; PPV: positive predictive values; NPV: negative predictive values
  2. * Optimal cut-off values were determined by maximizing the Youden index
  3. CAD and VTI at 2 cm proximal to the carotid bulb were measured
  4. Among the 78 patients who met the inclusion criteria, 6 were excluded, 72 were agreed by consent, 72 were studied, 31 were in the Responders group and 41 were in the Non-Responders group
  5. SVI: stroke volume index; CSEA: combined spinal-epidural anaesthesia
  6. Upper row: individual responses to fluid challenge for VTI(A) and CABF(B). Responders are presented as blue full line and closed circles; Non-responders are presented as red dashed line and open circles
  7. Lower row: receiver operating characteristic curves showing the ability of VTI (C) and CABF (D) before fluid challenge to discriminate responders and non-responders
  8. The areas under the curves for VTI and CABF were 0.802 (95% confidence interval 0.706–0.898), 0.812 (95% confidence interval 0.714–0.909), and 0.846 (95% confidence interval 0.762–0.930), respectively
  9. Responders are represented by blue full lines and closed circles; Non-responders are represented by red dashed lines and open circles
  10. VTI: carotid artery velocity time integral;CABF: carotid artery blood flow
  11. Red dotted lines indicate the mean difference (bias), and black dotted lines indicate the 95% limits of agreement (1.96 x standard deviation)
Back to article page

BMC Pregnancy and Childbirth

ISSN: 1471-2393

Contact us