Table 3 Histopathological changes in the organs of deceased patients
№ | Lungs | Brain | Intestine | Heart | Liver | Spleen | Kidneys | Uterus | Placenta |
|---|---|---|---|---|---|---|---|---|---|
1 | DAD, proliferative type; interstitial infiltrates of lymphocytes and histiocytes, acute bacterial pneumonia, alveolar/capillary megakaryocytes, vasculitis, microthrombi | Edema, perivascular hemorrhage, karyolysis of neurons, vasculitis, microthrombi | Edema, erosion, necrosis, microvasculitis | Perivascular sclerosis, focal necrosis | Cholestasis, mild steatosis, centrilobular necrosis, lymphocytic infiltrates, microvasculitis | Lymphoid depletion, reduction of lymphoid follicles | Partial necronephrosis, vacuolation of the tubular epithelium, microthrombi | Myonecrosis, microthrombi | Placental abruption, acute intervillusitis, necrosis of the villous trophoblast, thrombi of the interstitial space, meconium in amniotic membranes, severe MVM |
2 | DAD, mixed type; interstitial infiltrates of lymphocytes, acute bacterial pneumonia, hemorrhages, alveolar megakaryocytes, microthrombi | Edema, neuronal karyolysis, microthrombi, vasculitis | Edema, necrosis, microvasculitis | Hypertrophy of cardiomyocytes, vasculitis | Severe steatosis, microvasculitis | Lymphoid depletion, reduction of lymphoid follicles | Partial necronephrosis, vacuolation of the tubular epithelium | Myonecrosis, microthrombi | Necrosis of the villous trophoblast, thrombosis of the interstitial space, severe MVM |
3 | DAD, mixed type; infiltrates of lymphocytes and histiocytes, alveolar/capillary megakaryocytes, vasculitis | Edema, microthrombi | Edema, erosion, vasculitis | Perivascular sclerosis | Mild steatosis, vasculitis | No significant changes | Arterionephrosclerosis, lymphocytic infiltration, focal segmental glomerulosclerosis, microthrombi | Edema, vasculitis | Mild FVM |
4 | DAD, mixed type; alveolar/capillary megakaryocytes, vasculitis | Edema, neuron karyolysis | Edema, erosion, vasculitis | Hypertrophy of cardiomyocytes, focal necrosis of cardiomyocytes | Mild steatosis, vasculitis | No significant changes | Mild arterionephrosclerosis, lymphocytic infiltration, microthrombi | Myonecrosis, vasculitis | Severe MVM, mild FVM |
5 | DAD, mixed type; interstitial infiltrates of lymphocytes and histiocytes, alveolar/capillary megakaryocytes, vasculitis, microthrombi | Edema, swelling, karyolysis of neurons, microthrombi, vasculitis | Edema, necrosis, erosion, vasculitis | Lymphocytic infiltrate, microthrombi | Moderate steatosis, lymphocytic infiltrates, cholestasis | Lymphoid depletion, reduction of lymphoid follicles | Mild arterionephrosclerosis, lymphocytic infiltration, microthrombi | Myonecrosis, vasculitis, microthrombi | Necrosis of the extracellular trophoblast, thrombosis of the intercellular space, severe MVM |
6 | DAD, mixed type; alveolar/capillary megakaryocytes, vasculitis, microthrombi | Edema, karyolysis of neurons, microthrombi, vasculitis | Edema, dystrophic changes | Focal necrosis of cardiomyocytes | Moderate steatosis | No significant changes | No significant changes | Vasculitis, microthrombi | Necrosis of the villous trophoblast, severe MVM |
7 | DAD, proliferative type; interstitial infiltrates of lymphocytes and histiocytes, alveolar/capillary megakaryocytes, vasculitis, microthrombi | Edema, swelling, karyolysis of neurons, microthrombi, vasculitis | Edema, necrosis, vasculitis | Subendocardial thrombi, focal necrosis, lymphocytic infiltration, microthrombi, vasculitis | Mild steatosis, focal centrilobular necrosis, vasculitis | Lymphoid depletion, reduction of lymphoid follicles | General necronephrosis, microthrombs | Myonecrosis, vasculitis, microthrombi | Placental abruption |
8 | DAD, mixed type; vasculitis, microthrombi | Edema, vasculitis | Edema, dystrophic changes, necrosis | No significant changes | Mild steatosis, cholestasis | No significant changes | Subtotal necronephrosis, microvasculitis | - | - |
9 | DAD, mixed type; vasculitis, microthrombi | Edema, microthrombi, vasculitis | Edema, hemorrhages | No significant changes | Mild steatosis, necrosis, reactive hepatitis | Reduction of lymphoid follicles | Partial necronephrosis, vacuolation of the tubular epithelium | Thrombosis of the uterine arteries | Mild chorioamnionitis without fetal inflammatory response |
10 | DAD, proliferative type, interstitial infiltrates of lymphocytes and histiocytes, acute bacterial pneumonia, alveolar megakaryocytes, vasculitis, microthrombi | Karyolysis of neurons, vasculitis | Vasculitis | Лимфоцитарный инфильтрат | Reactive hepatitis, vasculitis | Reduction of lymphoid follicles, microvasculitis | Total necronephrosis, lymphocytic infiltration, microvasculitis | Vasculitis, microthrombi | Placental abruption, severe MVM |
11 | Common thrombosis of the pulmonary arteries and microvessels of both lungs | Karyolysis of neurons, vasculitis | Vasculitis | No significant changes | No significant changes | Reduction of lymphoid follicles, vasculitis, hemophagocytosis | No significant changes | Vasculitis, microthrombi | Necrosis of the villous trophoblast, mild MVM, mild FVM |
12 | Interstitial fibrosis, vasculitis, microthrombi | Edema, neuronal karyolysis, vasculitis | Edema, hemorrhages, vasculitis | No significant changes | Mild steatosis | Reduction of lymphoid follicles | Subtotal necronephrosis | No significant changes | Severe MVM, mild FVM |