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Table 1 The pre-implantation genetic testing results of blastocysts from couples carrying non-complex BCR and complex BCR

From: Preimplantation genetic testing in couples with balanced chromosome rearrangement: a four-year period real world retrospective cohort study

 

Reciprocal translocation

Robertsonian translocation

Inversion

complex BCR

chi-q/Z

P-value

Male

Female

Total

Male

Female

Total

Male

Female

Total

Female age (y)§

30(28–33)

30(28–32)

30(28–32)

31(29–34)

30(28–33)

31(28.5–33)*

32(26.25–34)

30.5(28.75–34)

31 (27–34)

30 (28–32)

6.352

0.096

No of miscarriage before PGT§

1(0–2)

1(0–2)

1(0–2)

0(0–1)

1(0–2)

0(0–1)*

0(0–2)

1(0–2)

1(0–2)

1(0–2)

9.594

0.022#

Euploid rate in each PGT cycle§

0.25

(0.00–0.50)

0.25

(0.00–0.50)

0.25

(0.00–0.50)

0.50

(0.27–0.71)

0.40

(0.17–0.60)

0.50*

(0.21–0.67)

0.54

(0.23–0.96)

0.50

(0.13–1.00)

0.50

(0.19–1.00)

0.50

(0.30–0.59)

67.771

0.000#&

Euploid rate in total

30.47%

(422/1385)

29.78%

(464/1558)

30.11%

(886/2943)

51.03%

(247/484)

40.63%

(180/443)

46.06%

(427/927)*

61.32%

(65/106)

53.51%

(61/114)

57.27%

(126/220)

46.15%

(18/39)

130.326

0.000#&∋

Abnormalities associated with TC

71.24%

(686/963)

76.87%

(841/1094)

74.23%

(1527/2057)

45.15%

(107/237)

63.12%

(166/263)

54.60%*

(273/500)

31.71%

(13/41)

30.19%

(16/53)

30.85%

(29/94)

85.71%

(18/21)

141.813

0.000#&∋Δ

Abnormalities associated with both TC and other chromosomes

29.88%

(205/686)

31.51%

(265/841)

30.78%

(470/1527)

36.45%

(39/107)

33.73%

(56/166)

34.80%

(95/273)

76.92%

(10/13)

25%

(4/16)

48.28%

(14/29)

22.22%

(4/18)

4.921

0.178

Abnormalities unrelated to TC

20%

(277/1385)

16.24%

(253/1558)

18.01%

(530/2943)

26.86%

(130/484)

21.90%

(97/443)

24.49%

(227/927)

26.42%

(28/106)

32.46%

(37/114)

29.55%

(65/220)

7.69%

(3/39)

35.206

0.000&∋£

Mosaic rate

4.26%

(59/1385)

3.40%

(53/1558)

3.81%

(112/2943)

5.37%

(26/484)

5.64%

(25/443)

5.50%

(51/927)

5.66%

(6/106)

7.89%

(9/114)

6.82%

(15/220)

0

(0/39)

0.568

0.753

Live birth in each PGT cycle

One transplant

51.56%

(116/225)

57.83%

(133/230)

55.96%

(249/445)

55%

(55/100)

61.90%

(52/84)

58.15%

(107/184)

45%

(9/20)

38.10%

(8/21)

41.46%

(17/41)

57.14%

(4/7)

3.858

0.271

Two transplant

45.83%

(22/48)

42.42%

(14/33)

44.44%

(36/81)

45%

(9/20)

39.13%

(9/23)

41.86%

(18/43)

40%

(2/5)

60%

(3/5)

50%

(5/10)

100%

(2/2)

2.399

0.506

Three transplant

0

(0/4)

50%

(3/6)

30%

(3/10)

50%

(3/6)

100%

(3/3)

66.67%

(6/9)

100%

(2/2)

0

100%

(2/2)

0

4.063

0.120

  1. BCR balanced chromosome rearrangement, y years old, PGT preimplantation genetic testing, TC translocated chromosomes
  2. §Data was expressed with median (interquartile range, IQR)
  3. *Significant differences are observed between male subgroup and female subgroup
  4. #A significant difference was observed between the Robersonian and the reciprocal translocation groups
  5. &Significant differences were observed between the inversion and reciprocal groups
  6. ∋Significant differences were observed between the inversion and Robersonian groups
  7. ΔSignificant differences were observed between the complex BCR and inversion groups
  8. £Significant differences were observed between the complex BCR group and the other three groups