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Table 2 Comparison of neonatal amino acids and maternal laboratory biochemical indices of participants

From: The correlation between serum total bile acid and alanine aminotransferase of pregnant women and the disorders of neonatal hyperbilirubinemia-related amino acid metabolism

 

Variables

No-NHB

NHB

p-value

Neonatal

ALA (µmol/L)

265.6 (227.6-316.1)

251.8(189.1-287.3)

0.031

 

VAL (µmol/L)

137.9 (117.4-152.6)

118.5 (106.6-139.1)

0.001

 

ORN (µmol/L)

94.5 (75.7-115.6)

78.6 (60.1-101.1)

0.003

 

ARG (µmol/L)

7.7 (3.8–12.6)

11.2 (6.1–15.7)

0.009

 

LEU + ILE (µmol/L)

146.3 (125.6-169.7)

139.6 (120.9-160.6)

0.133

 

MET (µmol/L)

24.0 (19.4–28.8)

23.9 (19.7–30.5)

0.732

 

PHE (µmol/L)

52.4 (44.3–58.9)

49.5 (41.5–55.7)

0.081

 

TYR (µmol/L)

93.4 (68.5–113.0)

83.2 (50.4-116.4)

0.096

 

CIT (µmol/L)

12.7 (10.5–14.9)

13.8 (11.2–17.6)

0.078

 

PRO (µmol/L)

438.5 (358.7–532.0)

370.8 (325.0-443.9)

0.001

Maternal

ALT (U/L)

10.0 (7.0–13.0)

14.5 (9.0-62.3)

< 0.001

 

AST(U/L)

17.0 (15.0-22.8)

19.5 (16.0–51.0)

0.010

 

ALT/AST

0.6 (0.5–0.7)

0.8 (0.5–1.2)

< 0.001

 

TBIL (µmol/L)

7.9 (6.4–10.6)

8.6 (6.4–11.0)

0.676

 

DBIL (µmol/L

1.3 (1.0-1.9)

1.7 (1.0-2.2)

0.607

 

IBIL (µmol/L)

6.5 (5.4–8.4)

6.7 (5.2–9.4)

0.685

 

TBA (µmol/L)

3.0 (1.6–13.6)

18.0 (3.2–36.0)

< 0.001

 

TP (g/L)

61.9 (59.2–66.0)

61.6 (57.5–64.5)

0.057

 

ALB (g/L)

36.4 (35.1–37.8)

35.0 (31.3–37.1)

< 0.001

 

TG (mmol/L)

3.1 (2.5–3.8)

2.9 (2.0-4.5)

0.159

 

TC (mmol/L)

6.3 (5.5-7.0)

5.7 (4.8–6.9)

0.025

 

HDL (mmol/L)

1.9 (1.7–2.2)

1.7 (1.3–2.1)

0.004

 

LDL (mmol/L)

3.7 (3.0-4.2)

3.2 (2.7-4.0)

0.099

  1. ALA, alanine; VAL, valine; ORG, ornithine; ARG, arginine; LEU + ILE, leucine + isoleucine; MET, methionine; PHE, phenylalanine; TYR, tyrosine; CIT, citrulline; PRO, proline; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; TBA, total bile acid; TP, serum total protein; ALB, serum albumin; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein
  2. All continuous variables in the table were given as the medians (quartile1-quartile3) and we used Mann-Whitney U test to compare the differences between the No-NHB and NHB groups, p < 0.05 was considered to be significant