Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study

Table 2 The cutoff values and diagnostic characteristics of inflammatory markers identifying FIRS and histological chorioamnionitis

Cutoff value		AUC		Sensitivity		Specificity		PPV		NPV		Delong test P value
Cutoff value		AUC		%	95% CI	%	95% CI	%	95% CI	%	95% CI	Delong test P value
FIRS
suPAR	27.60	0.65	0.54–0.76	65	51–79	65	53–77	57	48–68	72	64–82	0.20^a
MMP-8	190.91	0.76	0.66–0.86	82	68–93	67	55–79	65	57–75	34	73–93	0.05^b
TNF-α	86.95	0.82	0.72–0.91	75	61–86	86	78–95	81	70–91	82	75–90	0.01^b
IL-6	27843.18	0.77	0.68–0.86	50	35–65	95	89–100	89	77–100	72	67–79	0.05^b
FIRS with histological chorioamnionitis
suPAR	27.60	0.74	0.64–0.84	79	64–91	67	56–79	53	44–64	88	80–94	0.20^a
MMP-8	171.18	0.84	0.75–0.92	94	85–100	59	47–71	53	46–61	95	88–100	0.14^c
TNF-α	97.89	0.84	0.76–0.92	76	62–91	53	46–61	71	59–83	88	81–95	0.11^c
IL-6	2695.68	0.82	0.73–0.91	61	45–76	95	88–100	85	72–96	83	77–89	0.30^c

MMP-8 matrix metalloproteinase-8, TNF-α tumor necrosis factor-α, IL-6 interleukin-6, FIRS fetal inflammatory response syndrome, AUC area under the curve, CI confidence intervals, PPV positive predictive value, NPV negative predictive value
^aP value represents the Delong test between suPAR ROC curve for FIRS compared to suPAR ROC curve for FIRS with histological chorioamnionitis
^bP value represents the suPAR ROC curve for FIRS compared to the ROC curve for FIRS of the other biomarkers
^cP value represents the suPAR ROC curve for FIRS with histological chorioamnionitis compared to the ROC curve for FIRS with histological chorioamnionitis of the other biomarkers

ISSN: 1471-2393