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Table 1 Demographic and clinical characteristics of the study population

From: Soluble urokinase plasminogen activator receptor in vaginally collected amniotic fluid predicting fetal inflammatory response syndrome: a prospective cohort study

Characteristics

FIRS group

(n = 48)

Non-FIRS group

(n = 66)

P value

Maternal characteristics

 Maternal age, years, mean ± SD

31.2

 ± 5.5

31.1

 ± 5.7

0.93

 Latency perioda, hours, median, IQR

23

4–51

26

11–59

0.12

 Gestational diabetes, n, %

10

21

13

20

0.91

 Group B streptococcus test positive, n, %

7

24

10

22

0.81

 Primigravida, n, %

17

46

31

40

0.57

 Primiparous, n, %

20

39

28

44

0.57

 Gestational age at PPROM, weeks, median, IQR

31

27–33

33

32–34

0.001

 Tocolytics, n, %

23

48

38

58

0.31

 Administration of antibiotics, n, %

48

100

66

100

0.45

 Antenatal glucocorticosteroids, n, %

41

85

55

83

0.76

 Mode of delivery, n, %

   vaginal delivery

43

90

55

83

0.42

   cesarean section

5

10

11

17

 Induction of delivery or cesarean section n, %

17

35

33

50

0.28

 Spontaneous delivery n, %

31

65

33

50

 Cause of initiating delivery, n, %

   Elevating maternal blood biomarkersb

10

58

9

27

0.13

    ≥ 34 weeks of gestation

2

12

7

21

   Prolonged latency period (> 7 days)

2

12

3

9

   Maternal condition

1

6

10

30

   Worsening fetal condition

2

12

3

9

   Umbilical cord prolapse

0

0

1

3

 Clinical chorioamnionitis, n, %

6

13

1

2

0.02

 Histological chorioamnionitis, n, %

38

79

15

23

 < 0.001

 Funisitis, n, %

21

44

0

-

 < 0.001

Neonatal characteristics

 Gestational age at birth, weeks, median, IQR

31

27–33

33

32–34

0.001

 Birthweight, grams, mean ± SD

1688

 ± 669

2070

 ± 555

0.01

 Apgar scores < 7 at 1 min., n, %

14

29

6

9

0.01

 Apgar scores < 7 at 5 min., n, %

6

13

1

2

0.04

 Umbilical cord arterial pH, Median, IQR

7.35

7.29–7.42

7.36

7.32–7.40

0.77

 Major outcomec, n, %

19

40

11

17

0.01

 Respiratory distress, n, %

46

96

48

73

0.001

 Severe respiratory distress syndromed, n, %

10

21

8

12

0.01

 Respiratory support, n, %

     

  None

2

4

18

27

0.01

  Mechanical ventilation

11

23

6

9

  Noninvasive respiratory therapy

35

73

42

64

 Neonatal death, n, %

1

2

0

-

0.42

 Sepsis, n %

8

17

2

3

0.02

 Early-onset sepsis

7

17

1

2

0.01

 Bronchopulmonary dysplasia, n, %

9

19

4

6

0.04

 Open ductus arteriosus, n %

8

17

8

12

0.46

 Retinopathy of prematurity

15

32

6

9

0.01

 Intraventricular hemorrhage, n, %

     

  None

29

60

46

70

0.24

  1–2 grade

14

29

18

27

  3–4 grade

5

10

2

3

  1. FIRS fetal inflammatory response syndrome, SD standard deviation, IQR interquartile range
  2. aThe time from preterm premature rupture of the membrane to delivery
  3. bC-reactive protein, white blood cell count, and neutrophil count
  4. cMajor neonatal outcomes were diagnosed if one or more of the following occurred: severe respiratory distress syndrome, the need for mechanical ventilation, death, early sepsis, early hypotension, severe intraventricular hemorrhage, bronchopulmonary dysplasia, and severe retinopathy of prematurity
  5. dThe criteria for severe respiratory distress syndrome (Grade 3 and 4) included opaque lungs and/or alveolar shadowing obscuring the cardiac border in the chest radiogram
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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