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Table 3 Obstetric outcomes between two group

From: Recombinant human thrombopoietin therapy for primary immune thrombocytopenia in pregnancy: a retrospective comparative cohort study

Variables

Control group

(n = 48)

rhTPO group

(n = 33)

Statistical value

P

Gestational weeks of delivery (weeks)

37.1 (37, 37.2)

37.6 (37, 38.4)

-3.356a

0.001

Mode of delivery

  

1.591b

0.207

 Vaginal delivery, n (%)

10 (20.8)

11 (33.3)

  

 Cesarean section, n (%)

38 (79.2)

22 (66.7)

  

Postpartum hemorrhage, n (%)

  

0.188b

0.665

 No

41 (85.4)

27 (81.8)

  

 Yes

7 (14.6)

6 (18.2)

  

Postpartum hemorrhage (ml)

500 (400, 800)

500 (234, 680)

-0.697a

0.486

Fetal or neonatal complications, n (%)

  

0.313b

0.576

 No

32 (66.7)

20 (60.6)

  

 Yes

16 (33.3)

13 (39.4)

  

Premature, n (%)

  

0.031b

0.859

 No

40 (83.3)

27 (81.8)

  

 Yes

8 (16.7)

6 (18.2)

  

Low birth weight (< 2.5 kg), n (%)

  

0.405b

0.524

 No

43 (89.6)

28 (84.8)

  

 Yes

5 (10.4)

5 (15.2)

  

Neonatal platelets < 100 × 109/L, n (%)

  

0.100b

0.752

 No

35 (72.9)

23 (69.7)

  

 Yes

13 (27.1)

10 (30.3)

  

Apgar score≦7 at 1 min, n (%)

  

NA

0.511c

 No

46 (95.8)

33 (100)

  

 Yes

2 (4.2)

0 (0)

  

Neonatal platelets on day 1(× 109/L)

150 (106.8, 181)

123 (90.5, 156)

-1.558a

0.119

Neonatal platelets on day 3(× 109/L)

151 (87.8, 188)

121 (72, 162)

-1.761a

0.078

Neonatal platelets on day 5(× 109/L)

170 (107.5, 204)

165 (113, 183)

-1.077a

0.282

  1. Postpartum hemorrhage was defined as a blood loss of ≥ 500 ml from the genital tract for vaginal deliveries and ≥ 1000 ml for caesarean sections, within 24 h of delivery
  2. Fetal or neonatal complications: including premature, low birth weight, neonatal platelets < 100 × 109/L, Apgar score≦7 at 1 min, fetal malformations, stillbirth and neonatal death
  3. Abbreviations: NA not applicable
  4. aMann-Whitney U Test
  5. bChi-square test
  6. cFisher exact probability test