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Table 1 Maternal baseline characteristics

From: Recombinant human thrombopoietin therapy for primary immune thrombocytopenia in pregnancy: a retrospective comparative cohort study

Variables

Control group

(n = 48)

rhTPO group

(n = 33)

Statistical value

P

Age

30 (27.3, 32)

29 (26, 30)

-1.352a

0.176

BMI (kg/m2)

24.4 ± 2.3

24.6 ± 4.0

-0.407b

0.685

Monthly income (CNY)

  

1.077c

0.584

  < 5000

13 (27.1)

9 (27.3)

  

 5000–10000

30 (62.5)

18 (54.5)

  

  > 10000

5 (10.4)

6 (18.2)

  

Number of births, n (%)

  

3.057c

0.217

 0

25 (52)

22 (67)

  

 1

19 (40)

7 (21)

  

 2

4 (8)

4 (12)

  

Diagnosis of ITP, n (%)

  

0.087c

0.768

 Before pregnancy

38 (79)

27 (82)

  

 In pregnancy

10 (21)

6 (18)

  

pre-pregnancy platelet(× 109/L)

38 (29.3, 73.8)

45 (37, 64)

-1.491a

0.136

Platelet antibodies, n (%)

  

0.320c

0.572

 No

8 (17)

4 (12)

  

 Yes

40 (83)

29 (88)

  

Obesity (BMI≧30)

  

NA

0.393d

 No

46 (95.8)

30 (90.9)

  

 Yes

2 (4.2)

3 (9.1)

  

Diabetes

  

NA

0.393d

 No

46 (95.8)

30 (90.9)

  

 Yes

2 (4.2)

3 (9.1)

  

Hypertension

  

NA

0.393d

 No

46 (95.8)

30 (90.9)

  

 Yes

2 (4.2)

3 (9.1)

  

Medications, n (%)

  

NA

0.683d

 No

45 (89.6)

30 (90.9)

  

 Yes

3 (10.4)

3 (9.1)

  

Baseline bleeding score, n (%)

  

0.526c

0.468

 0

36 (75)

27 (81.8)

  

 1

9 (18.8)

1 (3)

  

 2

3 (6.3)

5 (15.2)

  

Baseline blood values

 Platelets(× 109/L)

18.6 ± 7.6

15 ± 8.9

1.970b

0.052

 White cell count (× 109/L)

6.6 (4.7, 10.8)

7.3 (5.4, 11.5)

-0.745a

0.456

 Neutrophil (%)

65.9 (52.1, 77.9)

71.7 (55.5, 78.5)

-0.971a

0.332

 Lymphocyte (%)

26.8 (15.9, 38.7)

19.6 (14.6, 29.2)

-1.216a

0.224

 Hemoglobin (g/L)

105.5 (90, 116.8)

107 (90.5, 115)

-0.125a

0.901

 Hematocrit (%)

31 (25.9, 33)

31 (24, 35)

-0.644a

0.519

 MPV (fL)

12.5 ± 2.3

12 ± 2.1

0.963a

0.338

 PDW (%)

15 (13, 18.9)

15.3 (14.6, 20.8)

-0.870a

0.384

 P-LCR (%)

38.9 ± 11.7

37.7 ± 9.2

0.478b

0.634

 NLR

0.7 (0.4, 1.4)

0.6 (0.3, 1.2)

-1.447a

0.148

 PLR

11.4 (7, 15.5)

9.2 (4.4, 17.6)

-1.043a

0.297

 Prothrombin time (s)

12.3 ± 0.8

12.2 ± 0.6

0.919b

0.361

 Activated partial thromboplastin time(s)

29.8 ± 3.6

31.3 ± 4.2

-1.683b

0.096

 Fibrinogen (g/L)

4.2 ± 1.1

4.2 ± 1.1

0.076b

0.940

 Dimer, μg/ml

2.5 (1.4, 5.5)

2.2 (1.4, 5.4)

-0.005a

0.996

  1. Abbreviations: BMI body mass index, NA not applicable, MPV mean platelet volume, PDW platelet distribution width, P-LCR platelet-large cell ratio, NLR neutrophil–lymphocyte ratio, PLR platelet-lymphocyte ratio
  2. aMann-Whitney U Test
  3. bIndependent-Samples Test
  4. cChi-square test
  5. dFisher exact probability test