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Table 3 Relative Risk (RR)1 and Ratio of Ratios (RoR)2 for the association between; preterm birth, early preterm birth, and at least one twin being classified as low birth weight or small for gestational age and interpregnancy intervals (IPIs) in twin pregnancies

From: Interpregnancy interval and adverse birth outcomes: a population-based cohort study of twins

Outcome Variable and Cohort

Interpregnancy Interval (months)

aRR [95% CI]c

 < 6

6–11

12–17

18–23

24–59

60–119

 ≥ 120

Preterm Birth

IPIa

1.05 [0.94–1.18]

0.99 [0.90–1.08]

0.97 [0.89–1.05]

1 [referent]

1.04 [0.97–1.12]

1.12 [1.02–1.22]**

1.25 [1.10–1.41]***

Post-Birth IPIa

1.37 [1.22–1.53]***

1.22 [1.10–1.36]***

1.08 [0.97–1.20]

1 [referent]

1.01 [0.92–1.11]

0.96 [0.85–1.08]

0.98 [0.80–1.21]

RoRb

0.77 [0.66–0.91]

0.81 [0.70–0.93]

0.90 [0.79–1.03]

1 [referent]

1.03 [0.92–1.16]

1.17 [1.01–1.35]

1.27 [1.00–1.62]

Early Preterm Birth

IPI

1.41 [1.08–1.83]*

1.17 [0.94–1.46]

0.99 [0.80–1.23]

1 [referent]

1.16 [0.96–1.39]

1.19 [0.94–1.51]

1.42 [1.01–2.00]*

Post-Birth IPI

2.03 [1.61–2.55]***

1.45 [1.16–1.81]**

0.99 [0.78–1.26]

1 [referent]

0.88 [0.72–1.07]

0.84 [0.66–1.08]

0.73 [0.45–1.19]

RoR

0.69 [0.49–0.99]

0.81 [0.59–1.10]

1.00 [0.73–1.38]

1 [referent]

1.32 [1.01–1.73]

1.41 [1.01–2.00]

1.94 [1.08–3.53]

Small for Gestational Age

IPI

1.20 [0.90–1.59]

1.24 [1.01–1.54]*

1.14 [0.93–1.40]

1 [referent]

1.14 [0.95–1.36]

1.19 [0.95–1.51]

1.30 [0.90–1.86]

Post-Birth IPI

1.50 [1.17–1.92]***

1.13 [0.90–1.42]

0.85 [0.67–1.08]

1 [referent]

0.86 [0.71–1.05]

0.90 [0.71–1.14]

0.93 [0.61–1.41]

RoR

0.80 [0.55–1.16]

1.10 [0.80–1.50]

1.34 [0.98–1.83]

1 [referent]

1.32 [1.01–1.72]

1.33 [0.95–1.85]

1.39 [0.80–2.42]

Low Birth Weight

IPI

1.16 [1.06–1.28]**

1.09 [1.01–1.19]*

1.01 [0.93–1.09]

1 [referent]

1.06 [0.99–1.14]

1.17 [1.08–1.28]***

1.20 [1.05–1.36]**

Post-Birth IPI

1.30 [1.19–1.42]***

1.17 [1.07–1.27]***

1.03 [0.94–1.12]

1 [referent]

1.01 [0.93–1.09]

0.99 [0.90–1.09]

0.87 [0.72–1.05]

RoR

0.90 [0.78–1.02]

0.93 [0.83–1.05]

0.98 [0.87–1.11]

1 [referent]

1.05 [0.95–1.17]

1.19 [1.05–1.35]

1.38 [1.10–1.73]

  1. IPI was defined as the time between the birth of twins (i.e., IPI cohort pregnancy) and the start of the subsequent pregnancy (n = 6,336 twin pregnancies)
  2. Post-birth IPI was defined as the time between the birth of the twins (i.e., post-birth IPI cohort pregnancy) and the start of pregnancy of the immediately subsequent pregnancy (n = 3,531 twin pregnancies)
  3. aData is presented as relative risk [95% Confidence Intervals]
  4. bRoR was derived as the adjusted RR for the association with IPI divided by the adjusted RR for the association with post-birth IPI. Data is presented as Ratio of Relative Risk [95% Confidence Intervals]
  5. cAll data was based on pooled analysis from 20 imputed datasets and adjusted for parity, birth year category, maternal ethnicity, maternal marital status at time of birth, maternal age at time of birth, maternal occupational status scale at time of birth, previous maternal history for each respective outcome variable, and IRSD category, with respect to the twin pregnancy for both the IPI and post-birth IPI cohorts
  6. ***p < 0.001, **p < 0.01, *p < 0.05