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Table 5 Performance of different serum marker MoM in combined first-trimester screening

From: A new contingent screening strategy increased detection rate of trisomy 21 in the first trimester

Serum marker

Abnormal serum marker*

Trisomy 21**

OAPR

free β-hCG MoM

PAPP-A MoM

n

%

n

%

 

2.00

0.10

3,537

10.10

1

2.13

1:3,537

2.00

0.20

3,597

10.27

2

4.26

1:1,799

2.00

0.30

3,889

11.10

3

6.38

1:1,296

2.00

0.40

4,726

13.49

4

8.51

1:1,182

2.00

0.50

6,271

17.90

6

12.77

1:1,045

2.00

0.60

8,215

23.45

6

12.77

1:1,369

2.00

0.70

10,525

30.05

6

12.77

1:1,754

2.00

0.80

12,995

37.10

6

12.77

1:2,166

2.25

0.10

2,432

6.94

1

2.13

1:2,432

2.25

0.20

2,492

7.11

2

4.26

1:1,246

2.25

0.30

2,784

7.95

3

6.38

1:928

2.25

0.40

3,625

10.35

4

8.51

1:906

2.25

0.50

5,183

14.80

6

12.77

1:864

2.25

0.60

7,168

20.46

6

12.77

1:1,195

2.25

0.70

9,534

27.22

6

12.77

1:1,589

2.25

0.80

12,074

34.47

6

12.77

1:2,012

2.50

0.10

1,724

4.92

1

2.13

1:1,724

2.50

0.20

1,784

5.09

2

4.26

1:892

2.50

0.30

2,076

5.93

3

6.38

1:692

2.50

0.40

2,919

8.33

4

8.51

1:730

2.50

0.50

4,484

12.80

6

12.77

1:747

2.50

0.60

6,489

18.53

6

12.77

1:1,082

2.50

0.70

8,886

25.37

6

12.77

1:1,481

2.50

0.80

11,462

32.72

6

12.77

1:1,910

2.75

0.10

1,243

3.55

1

2.13

1:1,243

2.75

0.20

1,303

3.72

2

4.26

1:652

2.75

0.30

1,595

4.55

3

6.38

1:532

2.75

0.40

2,439

6.96

4

8.51

1:610

2.75

0.50

4,005

11.43

6

12.77

1:668

2.75

0.60

6,022

17.19

6

12.77

1:1,004

2.75

0.70

8,439

24.09

6

12.77

1:1,407

2.75

0.80

11,045

31.53

6

12.77

1:1,841

3.00

0.10

869

2.48

0

0.00

-

3.00

0.20

929

2.65

1

2.13

1:929

3.00

0.30

1,221

3.49

2

4.26

1:611

3.00

0.40

2,064

5.89

3

6.38

1:688

3.00

0.50

3,631

10.37

5

10.64

1:726

3.00

0.60

5,652

16.14

5

10.64

1:1,130

3.00

0.70

8,088

23.09

5

10.64

1:1,618

3.00

0.80

10,710

30.58

5

10.64

1:2,142

  1. *the number of abnormal serum marker in low risk. **the number of trisomy 21 of abnormal serum marker and low risk
  2. β-hCG, beta-human chorionic gonadotropin, PAPP-A, pregnancy-associated plasma protein-A, MoM,multiples of the median, OAPR: Odds of being affected given a positive result