A new contingent screening strategy increased detection rate of trisomy 21 in the first trimester

Table 4 Performance of different serum marker MoM in serum biochemical screening

Serum marker		Abnormal serum marker*		Trisomy 21**		OAPR
free β-hCG MoM	PAPP-A MoM	n	%	n	%
2.00	0.10	1,505	4.26	2	4.26	1:753
2.00	0.20	1,533	4.34	2	4.26	1:767
2.00	0.30	1,704	4.83	2	4.26	1:852
2.00	0.40	2,252	6.38	3	6.38	1:751
2.00	0.50	3,337	9.45	5	10.64	1:667
2.00	0.60	4,885	13.84	5	10.64	1:977
2.00	0.70	6,811	19.29	7	14.89	1:973
2.00	0.80	9,061	25.66	8	17.02	1:1,133
2.25	0.10	891	2.52	2	4.26	1:446
2.25	0.20	919	2.60	2	4.26	1:460
2.25	0.30	1,090	3.09	2	4.26	1:545
2.25	0.40	1,638	4.64	3	6.38	1:546
2.25	0.50	2,723	7.71	5	10.64	1:545
2.25	0.60	4,271	12.10	5	10.64	1:854
2.25	0.70	6,197	17.55	7	14.89	1:885
2.25	0.80	8,447	23.92	8	17.02	1:1,056
2.50	0.10	561	1.59	2	4.26	1:281
2.50	0.20	589	1.67	2	4.26	1:295
2.50	0.30	760	2.15	2	4.26	1:380
2.50	0.40	1,308	3.70	3	6.38	1:436
2.50	0.50	2,393	6.78	5	10.64	1:479
2.50	0.60	3,941	11.16	5	10.64	1:788
2.50	0.70	5,867	16.62	7	14.89	1:838
2.50	0.80	8,117	22.99	8	17.02	1:1,015
2.75	0.10	362	1.03	2	4.26	1:181
2.75	0.20	390	1.10	2	4.26	1:195
2.75	0.30	561	1.59	2	4.26	1:281
2.75	0.40	1,109	3.14	3	6.38	1:370
2.75	0.50	2,194	6.21	5	10.64	1:439
2.75	0.60	3,742	10.60	5	10.64	1:748
2.75	0.70	5,668	16.05	7	14.89	1:810
2.75	0.80	7,918	22.43	8	17.02	1:990
3.00	0.10	221	0.63	0	0.00	-
3.00	0.20	249	0.71	0	0.00	-
3.00	0.30	420	1.19	0	0.00	-
3.00	0.40	968	2.74	1	2.13	1:968
3.00	0.50	2,053	5.81	3	6.38	1:684
3.00	0.60	3,601	10.20	3	6.38	1:1,200
3.00	0.70	5,527	15.65	5	10.64	1:1,105
3.00	0.80	7,777	22.03	6	12.77	1:1,296

*the number of abnormal serum marker in low risk. **the number of trisomy 21 of abnormal serum marker in low risk
β-hCG, beta-human chorionic gonadotropin, PAPP-A, pregnancy-associated plasma protein-A, MoM,multiples of the median, OAPR: Odds of being affected given a positive result

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