Table 6 Baseline characteristics and pregnancy outcomes of patients with different failure cycles in two groups (\(\bar x\) ± s; %)
Indicators | with two failure cycles | with three failure cycles | with more than three failure cycles | ||||||
|---|---|---|---|---|---|---|---|---|---|
Conventional ET (n = 450) | Sequential ET (n = 192) | P-value | Conventional ET (n = 402) | Sequential ET (n = 106) | P-value | Conventional ET (n = 228) | Sequential ET (n = 62) | P-value | |
Age (yr) | 31.17 ± 4.11 | 31.36 ± 4.43 | 0.672 | 32.18 ± 4.68 | 31.20 ± 4.04 | 0.088 | 32.07 ± 4.72 | 32.16 ± 4.46 | 0.920 |
BMI (kg/m2) | 22.65 ± 3.41 | 22.54 ± 3.15 | 0.755 | 22.42 ± 3.8 | 22.66 ± 3.3 | 0.616 | 23.41 ± 3.30 | 22.82 ± 3.21 | 0.468 |
Infertility duration (yr) | 3.64 ± 2.49 | 4.20 ± 2.97 | 0.061 | 3.88 ± 2.96 | 3.25 ± 3.27 | 0.071 | 3.66 ± 3.11 | 3.04 ± 2.01 | 0.160 |
AMH (ng/ml) | 6.50 ± 5.18 | 5.66 ± 4.20 | 0.098 | 5.38 ± 4.54 | 5.69 ± 5.27 | 0.624 | 4.73 ± 4.30 | 5.03 ± 3.75 | 0.671 |
bFSH (mIU/ml) | 6.36 ± 2.83 | 6.44 ± 2.71 | 0.798 | 6.54 ± 2.49 | 7.03 ± 2.60 | 0.135 | 7.03 ± 4.91 | 6.29 ± 2.08 | 0.234 |
Endometrial thickness (mm) | 10.69 ± 2.36 | 10.94 ± 1.95 | 0.293 | 11.04 ± 1.85 | 10.74 ± 1.84 | 0.205 | 11.17 ± 2.23 | 10.97 ± 1.99 | 0.586 |
High-quality enbryo rate | 48.1 (433/900) | 45.3 (193/426) | 0.339 | 39.9 (321/804) | 42.2 (105/249) | 0.529 | 38.4 (175/456) | 46.4 (70/151) | 0.083 |
Primary infertlity rate | 58.7 (264/450) | 64.1 (123/192) | 0.201 | 51.5 (207/402) | 60.4 (64/106) | 0.103 | 47.4 (108/228) | 38.7 (24/62) | 0.225 |
Infertility factors | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Male factors | 20.0 (90/450) | 25.5 (49/192) | 0.120 | 19.4 (78/402) | 19.8 (21/106) | 0.925 | 19.7 (45/228) | 25.8 (16/62) | 0.298 |
Tube and pelvic factors | 46.0 (207/450) | 42.7 (82/192) | 0.443 | 44.0 (177/402) | 44.3 (47/106) | 0.954 | 32.9 (75/228) | 29.0 (18/62) | 0.563 |
Ovulatory factors | 6.7 (30/450) | 6.3 (12/192) | 0.845 | 6.0 (24/402) | 3.8 (4/106) | 0.378 | 5.3 (12/228) | 3.2 (2/62) | 0.507 |
Bilateral factors | 21.3 (96/450) | 17.2 (33/192) | 0.230 | 23.1 (93/402) | 23.6 (25/106) | 0.922 | 28.9 (66/228) | 22.6 (14/62) | 0.320 |
Others | 6.0 (27/450) | 8.3 (16/192) | 0.279 | 7.5 (30/402) | 8.5 (9/106) | 0.724 | 13.2 (30/228) | 19.4 (12/62) | 0.219 |
Clinical pregnancy rate | 33.3 (150/450) | 35.4 (68/192) | 0.610 | 19.4 (78/402) | 31.1 (32/106) | 0.020* | 11.8 (27/228) | 22.6 (14/62) | 0.031* |
Implantation rate | 20.1 (181/900) | 20.2 (86/426) | 0.974 | 11.9 (96/804) | 18.1 (45/249) | 0.013* | 7.2 (33/456) | 12.6 (19/151) | 0.040* |
Multiple pregnancy rate | 20.7 (31/150) | 22.1 (15/68) | 0.815 | 23.1 (18/78) | 25.0 (8/32) | 0.829 | 22.2 (6/27) | 21.4 (3/14) | 0.954 |
Miscarriage rate | 16.0 (24/150) | 16.2 (11/68) | 0.974 | 7.7 (6/78) | 9.4 (3/32) | 0.770 | - | 5.6 (1/18) | - |