Table 1 Demographic and foetal tissue chromosome karyotypes of SA patients in 5 regions (6 hospitals)

Age

30.8 ± 4.7

29.2 ± 4.5 ^abcd

31.3 ± 4.6

31.3 ± 4.4

32.2 ± 4.9 ^j

30.6 ± 4.5

23.8

 < 0.001

Age of foetal tissue chromosome karyotypes

 Normal

30.6 ± 4.4

28.9 ± 4.3 ^abcd

31.1 ± 3.8

31.3 ± 4.2 h

31.6 ± 4.3 ^j

30.0 ± 4.5

10.4

 < 0.001

 Abnormal

30.9 ± 4.9

29.4 ± 4.6 ^abcd

31.4 ± 5.0

31.2 ± 4.5 ^hi

32.9 ± 5.3 ^j

30.8 ± 4.6

16.1

 < 0.001

Number of foetal tissue chromosome karyotypes

 Normal

763(39.5)

145(35.8)

36(35.0)

146(50.0)

228(52.8)

208(31.0)

68.216

 < 0.001

 Abnormal

1140(60.5)

260(64.2) ^bc

67(65.0)^ef

146(50.0) ⁱ

204(47.2) ^j

463(69.0)

Number of abnormal foetal tissue chromosome karyotypes ⁴

 One-chr

952(83.5)

198(76.2) ^bd

54(80.6) ^eg

97(66.4) ^hi

168(82.4)^j

435(94.0)

78.385

 < 0.001

 Two-chr

76(6.7)

17(6.5) ^bd

6(9.0) ^eg

32(21.9) ^hi

9(4.4)

12(2.5)

53.809

 < 0.001

 Multiple-chr

112(9.8)

45(17.3) ^d

7(10.4) ^g

17(11.6) ⁱ

27(13.2) ^j

16(3.5)

44.297

 < 0.001

Categories of abnormal foetal tissue chromosome karyotypes

 Number

n = 1279

n = 284

n = 90

n = 191

n = 234

n = 480

 Triploid

102(8.0)

44(15.5) ^abd

4(4.4)

9(4.7) ^h

27(11.5) ^j

18(3.8)

39.688

 < 0.001

 Trisomy

584(45.7)

164(57.7) ^bd

43(47.8) ^g

72(37.7) ^h

136(58.1) ^j

169(35.2)

57.539

 < 0.001

 Mosaicism

127(9.9)

13(4.6) ^abd

11(12.2) ^f

24(12.6) ^h

8(3.4) ^j

71(14.8)

37.791

 < 0.001

 45,X

87(6.8)

28(9.9) ^b

8(8.9)

8(4.2)

13(5.6)

30(6.3)

7.409

0.112

 Microduplication

260(20.3)

9(3.2) ^abcd

9(10.0) ^eg

58(30.4) ^h

32(13.7) ^j

152(31.7)

113.938

 < 0.001

 Microdeletion

92(7.2)

20(7.0) ^a

15(16.7) ^fg

17(8.9)

16(6.8)

24(5.0)

14.301

0.006

 Monosomy

27(2.1)

6(2.1)

0(0.0)

3(1.6)

2(0.9) ^j

16(3.3)

6.369

0.148