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Table 2 Reference intervals for complete blood count parameters during pregnancy

From: Reference intervals of complete blood count and coagulation tests in Vietnamese pregnant women

 

First trimester (n = 287)

Second trimester (n = 273)

Third Trimester (n = 277)

Parameter

2.5th (90% CI)

97.5th (90% CI)

P1*

2.5th (90% CI)

97.5th (90% CI)

P2

2.5th (90% CI)

97.5th (90% CI)

P3

RBC (× 1012/L)

3.73 (3.50–3.78)

5.32 (5.07–5.50)

P1 < 0.001

3.33 (2.98–3.38)

4.98 (4.63–5.30)

P2 < 0.001

3.54 (3.16–3.68)

4.98 (4.88–5.65)

P3 < 0.001

HGB (g/dL)

10.33 (9.25–10.77)

13.95 (13.80–14.29)

P1 < 0.001

9.71 (8.59–9.96)

13.17 (12.83–13.67)

P2 < 0.001

9.80 (8.89–10.01)

13.97 (13.80–15.00)

P3 < 0.001

HCT (%)

32.22 (29.82–32.83)

42.29 (41.65–43.38)

P1 < 0.001

30.26 (28.06–30.96)

40.07 (39.59–41.49)

P2 < 0.001

31.11 (28.67–31.48)

42.70 (41.80–44.39)

P3 = 0.003

MCV (fL)

66.13 (62.88–69.69)

95.85 (93.75–97.61)

P1 < 0.001

69.14 (61.94–70.88)

97.79 (96.96–98.85)

P2 < 0.001

69.43 (57.73–72.52)

98.40 (96.41–101.12)

P3 = 0.012

MCH (pg)

20.57 (19.61–22.06)

31.78 (31.17–32.65)

P1 < 0.001

21.51 (18.65–22.49)

32.68 (32.17–33.10)

P2 < 0.001

21.18 (17.30–23.00)

32.47 (32.10–33.89)

P3 = 0.317

MCHC (g/dL)

31.13 (30.75–31.51)

33.85 (33.75–34.11)

P1 = 0.403

30.99 (30.04–31.63)

34.13 (34.02–34.46)

P2 < 0.001

30.70 (29.96–31.10)

33.94 (33.62–34.19)

P3 < 0.001

RDW (%)

12.27 (11.52–12.37)

17.78 (16.95–19.60)

P1 < 0.001

12.69 (12.41–12.78)

16.17 (15.48–23.10)

P2 < 0.001

12.75 (12.24–12.89)

17.29 (16.73–20.89)

P3 < 0.001

RDW-SD (fL)

35.09 (33.69–36.75)

50.49 (47.25–54.69)

P1 < 0.001

37.97 (34.13–38.50)

48.65 (48.13–49.44)

P2 = 0.001

37.63 (33.25–39.38)

52.52 (50.31–55.13)

P3 < 0.001

WBC (× 109/L)

6.33 (5.05–6.56)

15.24 (13.96–16.50)

P1 < 0.001

6.99 (3.52–7.34)

15.55 (14.76–16.77)

P2 < 0.001

6.22 (5.49–6.59)

14.14 (13.20–14.93)

P3 = 0.625

Neutrophil (× 109/L)

3.43 (2.62–4.08)

11.70 (10.39–12.38)

P1 < 0.001

4.57 (1.11–4.92)

12.25 (11.15–12.98)

P2 < 0.001

3.99 (3.00–4.31)

10.74 (9.94–12.01)

P3 = 0.761

Neutrophil (%)

55.71 (44.74–57.43)

80.31 (79.14–82.79)

 

59.72 (31.35–63.18)

79.61 (78.40–83.64)

 

58.01 (49.23–59.18)

80.30 (78.58–82.72)

 

Lymphocyte (× 109/L)

1.22 (0.91–1.32)

3.23 (3.09–3.34)

P1 = 0.850

1.24 (0.90–1.33)

3.03 (2.86–3.40)

P2 < 0.001

1.16 (0.78–1.24)

3.06 (2.73–3.57)

P3 < 0.001

Lymphocyte (%)

11.83 (7.71–13.39)

34.29 (30.71–38.31)

 

11.94 (9.40–12.97)

29.31 (27.19–39.79)

 

11.59 (9.60–12.65)

31.07 (29.20–35.81)

 

Monocyte (× 109/L)

0.35 (0.26–0.38)

1.12 (1.01–1.25)

P1 < 0.001

0.38 (0.01–0.42)

1.28 (1.17–1.34)

P2 = 0.066

0.43 (0.02–0.46)

1.21 (1.15–1.48)

P3 < 0.001

Monocyte (%)

3.93 (3.39–4.51)

10.59 (10.06–11.59)

 

4.17 (0.13–4.52)

10.26 (9.67–11.47)

 

4.60 (0.23–5.15)

11.94 (11.43–15.11)

 

Eosinophil (× 109/L)

0.02 (0.01–0.03)

0.50 (0.39–0.92)

P1 < 0.001

0.04 (0.00–0.05)

0.50 (0.44–0.86)

P2 < 0.001

0.03 (0.02–0.04)

0.39 (0.35–0.54)

P3 = 0.152

Eosinophil (%)

0.22 (0.08–0.28)

4.79 (4.42–6.55)

 

0.34 (0.05–0.49)

4.64 (4.12–7.86)

 

0.33 (0.16–0.37)

3.74 (3.39–4.91)

 

Basophil (× 109/L)

0.01 (0.01–0.01)

0.09 (0.08–0.13)

P1 = 0.769

0.01 (0.00–0.01)

0.09 (0.08–0.11)

P2 = 0.993

0.01 (0.01–0.01)

0.09 (0.08–0.15)

P3 = 0.708

Basophil (%)

0.10 (0.07–0.13)

0.92 (0.80–1.22)

 

0.10 (0.00–0.12)

0.76 (0.69–0.92)

 

0.12 (0.06–0.13)

0.93 (0.79–1.61)

 

Platelet (× 109/L)

169.66 (157.10–192.40)

413.88 (389.50–508.40)

P1 = 0.007

172.34 (85.40–182.60)

372.19 (359.10–426.00)

P2 = 0.157

151.30 (117.80–160.50)

417.14 (400.40–491.30)

P3 < 0.001

MPV (fL)

6.65 (6.39–6.74)

9.85 (9.67–9.99)

P1 = 0.139

6.48 (6.11–6.63)

9.70 (9.36–9.92)

P2 < 0.001

6.69 (6.29–6.96)

10.39 (9.98–11.19)

P3 < 0.001

  1. *P values for First trimester vs Second trimester
  2. P values for Second trimester vs Third trimester
  3. P values for First trimester vs Third trimester