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Table 6 Diagnostic criteria for 3-hydroxypropionic acid and uracil for ICP

From: Identification and validation of diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on untargeted and targeted metabolomics analyses of urine metabolite profiles

Biomarker

Cutoff value (ng/mL)

Diagnostic sensitivity

Diagnostic specificity

Youden index

AUC

3-hydroxypropionic acid

19681.936

0.800

0.900

0.7

0.920

28799.566

0.900

0.800

0.7

uracil

2938.360

0.900

0.700

0.6

0.850

3271.682

1.000

0.600

0.6