Table 3 Metabolites changed in intrahepatic cholestasis of pregnancy (ICP) urine specimens (negative ion mode)
Name | VIP | P-value | Fold change |
|---|---|---|---|
Sulfochenodeoxycholic acid | 2.484 | 0.008 | 242.582 |
Cholic acid | 2.254 | 0.009 | 55.967 |
Glycochenodeoxycholic acid | 1.461 | 0.043 | 8.302 |
Taurocholic acid | 1.697 | 0.045 | 8.039 |
Glycocholic acid | 1.849 | 0.006 | 3.720 |
 L-Glutamic acid | 1.340 | 0.029 | 0.844 |
2-Oxoadipate | 1.400 | 0.031 | 0.738 |
 N-Acetylglutamic acid | 1.399 | 0.047 | 0.709 |
 L-Pyroglutamic acid | 1.465 | 0.021 | 0.687 |
 L-Threonic acid | 1.710 | 0.004 | 0.674 |
Xanthosine | 1.328 | 0.047 | 0.673 |
N2-Methylguanosine | 1.536 | 0.016 | 0.636 |
Mevalonic acid | 1.380 | 0.019 | 0.622 |
Geranic acid | 1.543 | 0.043 | 0.606 |
 L-Histidine | 1.401 | 0.041 | 0.598 |
Imidazoleacetic acid | 1.636 | 0.035 | 0.559 |
DL-4-Hydroxy-3-methoxymandelic acid | 1.447 | 0.039 | 0.555 |
 N-Methylleucine | 1.745 | 0.028 | 0.553 |
3-Methoxyphenylacetic acid | 1.498 | 0.047 | 0.524 |
Ethylmalonic acid | 1.634 | 0.032 | 0.509 |
Perillic acid | 1.762 | 0.008 | 0.463 |
D-Glutamine | 1.662 | 0.029 | 0.450 |
2,3-dinor Prostaglandin E1 | 2.238 | 0.000 | 0.434 |
Glycyl-L-leucine | 1.645 | 0.018 | 0.432 |
Uracil | 1.800 | 0.002 | 0.390 |
 N-acetyltryptophan | 1.252 | 0.033 | 0.359 |
Hydroxyphenyllactic acid | 1.737 | 0.023 | 0.355 |
Nonanoic acid | 1.763 | 0.033 | 0.284 |