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Table 2 Metabolites changed in intrahepatic cholestasis of pregnancy (ICP) urine specimens (positive ion mode)

From: Identification and validation of diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on untargeted and targeted metabolomics analyses of urine metabolite profiles

Name

VIP

P-value

Fold change

Acetylproline

2.528

0.001

32.157

 N-Acetylmannosamine

1.839

0.009

7.482

3-oxo lithocholic acid

2.324

0.001

5.429

19(R)-hydroxy Prostaglandin A2

1.598

0.036

3.736

Threonine

1.778

0.022

3.635

1-Aminocyclopropanecarboxylate

1.639

0.047

2.726

17-alpha-Hydroxyprogesterone

1.627

0.045

2.415

Methionine sulfoxide

1.360

0.037

1.368

Indole-3-carboxylic acid

1.434

0.025

0.749

Adenine

1.494

0.007

0.714

2,4-Dihydroxy-butanoic acid

1.371

0.032

0.708

cytosine

1.282

0.038

0.696

Uracil

1.513

0.044

0.693

Indole

1.386

0.033

0.689

 N-alpha-Acetyl-L-lysine

1.728

0.015

0.686

3-Methyladenine

1.544

0.013

0.657

Testosterone

1.517

0.045

0.642

 N,N-Dimethylarginine

1.804

0.008

0.636

Creatine

1.570

0.010

0.634

Creatinine

1.732

0.002

0.630

Glycylproline

1.684

0.017

0.601

4-PREGNEN-20-ALPHA-OL-3-ONE

1.378

0.040

0.587

3-Hydroxypropionic acid

1.456

0.034

0.585

Guanidinoacetate

1.650

0.020

0.568

Indolelactic acid

1.467

0.021

0.557

Estrone

1.361

0.048

0.544

3-Hydroxyphenylacetic acid

1.628

0.020

0.537

p-Benzoquinone

1.532

0.017

0.521

1-Methylnicotinamide

1.320

0.030

0.460

5,6-Dihydrouracil

2.123

0.002

0.460

Trigonelline

1.521

0.034

0.433

Androstenedione

1.804

0.004

0.428

Androsterone

1.647

0.009

0.405

p-Coumaric acid

1.732

0.001

0.310

Mono-iso-butyl phthalate

1.472

0.039

0.299

Cyclo-prolylglycine

1.741

0.026

0.272

  1. VIP, the variable importance in the projection; Fold change, the ratio of ICP/CON.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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