Identification and validation of diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on untargeted and targeted metabolomics analyses of urine metabolite profiles

Table 1 Demographics and baseline characteristics of the pregnant women

Index	CON (n = 10)	ICP (n = 10)	t/t’ test	P value
Age(year)			0.944	0.356
Mean ± SD.	33.3 ± 5.6	31.4 ± 4.2
Median(IQR)	33.0(28.0–38.0)	31.5(29.0–34.0)
Range	25.0–44.0	24.0–39.0
BMI (kg/m²)			0.271	0.789
Mean ± SD.	26.9 ± 3.3	26.6 ± 3.0
Median (IQR)	27.3(24.9–29.2)	27.2(24.5–28.4)
Range	20.6–32.9	19.5–31.3
TBA(µmol/L)			4.940	0.000
Mean ± SD.	3.6 ± 2.2	61.8 ± 40.7
Median (IQR)	3.0(2.2–4.4)	43.4(35.8–87.1)
Range	1.4–8.9	20.4–166.0
AST(µmol/L)			3.501	0.002
Mean ± SD.	18.8 ± 5.6	57.6 ± 38
Median (IQR)	18.0(14.4–24.0)	55.3(30.5–70.5)
Range	11.0-27.9	11.1-130.4
ALT(µmol/L)			3.561	0.002
Mean ± SD.	11.7 ± 7.1	91.8 ± 67.9
Median (IQR)	9.6(8.3–11.4)	62.3(17.7-144.4)
Range	6.3–33.3	3.7-212.1
ALP(µmol/L)			2.140	0.047
Mean ± SD.	167.7 ± 84.2	227.4 ± 47.4
Median (IQR)	143.7(107.7-189.8)	224.2(183.8-262.9)
Range	92.7–367.0	158.7-302.3
Time of onset (day)
Mean ± SD.		215.6 ± 55.9
Median (IQR)		237.0(196.0-246.0)
Range		63.0-266.0
Time of delivery (day)			6.668	0.000
Mean ± SD.	273.3 ± 2.6	256.8 ± 8.2
Median (IQR)	273.0(272.0-274.0)	256.5(249.0-266.0)
Range	269.0-279.0	246.0-267.0
Gravida(no.)			0.849	0.406
Mean ± SD.	2.6 ± 1.3	3.1 ± 1.6
Median (IQR)	2.5(1.0–4.0)	3.0(2.0–4.0)
Range	1.0–5.0	1.0–7.0
Para(no.)			0.573	0.573
Mean ± SD.	0.8 ± 0.6	0.9 ± 0.8
Median (IQR)	1.0(0.0–1.0)	1.0(0.0–2.0)
Range	0–2.0	0–2.0

Note: 1) The day of onset refers to the day during which TBA elevation was first detected;
2) When the variance of the two groups of data is homogeneous, the t test is used; When two sets of data have uneven variances, the t ‘test is used
3) no., number; SD., standard deviation; IQR, interquartile range

ISSN: 1471-2393