Table 3 Changes of fetal facial profile markers in fetuses with congenital malformations
Measures | Normal group (N = 406) | Abnormal group (N = 25) | P | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|
FMF | 0.021(3.100) | Bilateral cleft lip and palate | -6.189(2.461) | < 0.0001 | 100% (7/7) | 98.8% (401/406) |
Unilateral cleft lip and palate | 1.295(3.137) | > 0.05 | ||||
Micrognathia | 2.212(6.038) | > 0.05 | ||||
Open spina bifida | -10.929(7.794) | < 0.001 | 100% (4/4) | 98.8% (401/406) | ||
MNM | -0.006(2.096) | Bilateral cleft lip and palate | 10.208(6.909) | < 0.0001 | 100% (7/7) | 96.8% (393/406) |
Unilateral cleft lip and palate | 5.158(4.451) | < 0.0001 | 100% (7/7) | 96.8% (393/406) | ||
Micrognathia | 12.285(4.299) | < 0.0001 | 100% (7/7) | 96.8% (393/406) | ||
Open spina bifida | 11.099(7.209) | < 0.001 | 100% (4/4) | 96.8% (393/406) | ||
FMA | 0.004(3.791) | Bilateral cleft lip and palate | -3.011(3.140) | < 0.001 | 14.3% (1/7) | 98.5% (400/406) |
Unilateral cleft lip and palate | -5.266(6.830) | < 0.05 | 42.9% (3/7) | 98.5% (400/406) | ||
Micrognathia | -25.833(3.511) | < 0.0001 | 100% (7/7) | 98.5% (400/406) | ||
Open spina bifida | 5.346(9.797) | > 0.05 | ||||
IFA | -0.020(3.494) | Bilateral cleft lip and palate | -5.727(4.375) | < 0.001 | 57.1% (4/7) | 99.5% (404/406) |
Unilateral cleft lip and palate | -2.858(3.435) | < 0.05 | 14.3% (1/7) | 99.5% (404/406) | ||
Micrognathia | -19.868(6.643) | < 0.0001 | 100% (7/7) | 99.5% (404/406) | ||
Open spina bifida | -3.836(5.891) | < 0.05 | 50% (2/4) | 99.5% (404/406) | ||
FSD | 0.023(1.613) | Bilateral cleft lip and palate | 4.785(1.784) | < 0.0001 | 100% (7/7) | 97.8% (397/406) |
Unilateral cleft lip and palate | 1.574(2.109) | < 0.05 | 28.6% (2/7) | 97.8% (397/406) | ||
Micrognathia | 5.788(2.436) | < 0.0001 | 100% (7/7) | 97.8% (397/406) | ||
Open spina bifida | 2.913(0.519) | < 0.001 | 100% (4/4) | 97.8% (397/406) | ||
PL distance | 0.013(0.608) | Bilateral cleft lip and palate | -0.650(0.718) | < 0.05 | 42.9% (3/7) | 96.8% (393/406) |
Unilateral cleft lip and palate | 0.176(0.514) | > 0.05 | ||||
Micrognathia | -1.399(1.313) | < 0.001 | 71.4% (5/7) | 96.8% (393/406) | ||
Open spina bifida | -0.505(0.906) | > 0.05 | ||||
PMD | -0.016(0.843) | Cleft lip and palate | -3.316(0.741) | < 0.0001 | 100% (20/20) | 97.8% (397/406) |
MG | -0.009(0.073) | Cleft lip and palate | 1.001(0.682) | < 0.0001 | 100% (20/20) | 92.4% (375/406) |