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Table 2 The results of CMA and karotyping on 1044 pregnancies with single advanced maternal age (≥ 35)

From: Chromosome microarray analysis combined with karyotype analysis is a powerful tool for the detection in pregnant women with high-risk indicators

Age

Number

Aneuploidy

BCAs

CNV

CNV

P

LP

35

77

0

(0.00%)

2

(2.60%)

0

(0.00%)

0

(0.00%)

0

(0.00%)

36

298

1

(0.34%)

4

(1.34%)

4

(1.34%)

2

(0.67%)

2

(0.67%)

37

149

1

(0.67%)

0

(0.00%)

2

(1.34%)

2

(1.34%)

0

(0.00%)

38

133

1

(0.75%)

1

(0.75%)

2

(1.50%)

2

(1.50%)

0

(0.00%)

39

119

1

(0.84%)

1

(0.84%)

0

(0.00%)

0

(0.00%)

0

(0.00%)

40

96

1

(1.04%)

0

(0.00%)

1

(1.04%)

1

(1.04%)

0

(0.00%)

≥ 41

172

3

(1.74%)

0

(0.00%)

3

(1.74%)

2

(1.16%)

1

(0.58%)

All

1044

8

(0.77%)

8

(0.77%)

12

(1.15%)

9

(0.86%)

3

(0.29%)

  1. BCAs: balanced chromosome abnormalities; P: pathogenic; LP: likely pathogenic.
  2. Aneuploidy included mosaic.