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Table 3 Phenotypic distribution of eligible babies at Migori County Referral Hospital

From: Adapting the preterm birth phenotyping framework to a low-resource, rural setting and applying it to births from Migori County in western Kenya

Phenotypea ( N = 387)

n (%)

Single Condition

Multiple Conditions

Corresponding Conditionsb

1. None

158 (41.1%)

NA

NA

NA

2. Extrauterine infection

97 (25.1%)

37 (38.1%)

60 (61.9%)

Severe maternal condition (25.8%), antepartum stillbirth (19.6%), preeclampsia (9.3%), multiple gestation (9.3%), mid-to-late pregnancy bleeding (8.2%), fetal anomaly (6.21%), fetal distress (5.2%), chorioamnionitis (6.2%), fetal anomaly 6.2%)

HIVa

73 (76.8%)

60 (82.2%)

13 (17.8%)

Urinary tract infection (8.2%), syphilis (2.7%), malaria (1.4%), general infection (1.4%)

Urinary tract infection

24 (25.3%)

18 (75.0%)

6 (25.0%)

HIV (33.3%), malaria (8.3%), general infection (4.2%)

Malaria

4 (4.2%)

2 (50.0%)

2 (50.0%)

Urinary tract infection (50.0%), HIV (25.0%)

Syphilis

3 (3.2%)

1 (33.3%)

2 (66.7%)

HIV (66.7%)

General infection

3 (3.2%)

1 (33.3%)

2 (66.7%)

HIV (33.3%), urinary tract infection (33.3%)

3. Antepartum stillbirth

63 (16.7%)

26 (41.3%)

37 (58.7%)

Extrauterine infection (30.2%), severe maternal condition (23.8%), preeclampsia (14.3%), mid-to-late pregnancy bleeding (12.7%), chorioamnionitis (12.7%), multiple gestation (4.8%), fetal anomaly (3.2%), fetal anemia (1.6%)

4. Severe maternal condition

59 (15.6%)

16 (27.1%)

43 (72.9%)

Extrauterine infection (42.4%), antepartum stillbirth (25.4%), mid-to-late pregnancy bleeding (16.9%), preeclampsia (10.2%), fetal distress (6.8%), multiple gestation (6.8%), chorioamnionitis (8.5%), fetal anomaly (1.7%)

Anemiaa

41 (70.7%)

37 (90.2%)

4 (0.1%)

Chronic respiratory distress (4.9%), hypertension prior to pregnancy (2.4%), epilepsy (2.4%)

Chronic respiratory distress

13 (22.4%)

11 (84.6%)

2 (15.4%)

Anemia (15.4%)

Hypertension prior to pregnancy

3 (5.2%)

2 (66.7%)

1 (33.3%)

Anemia (33.3%)

Diabetes

2 (3.4%)

2 (100.0%)

-

-

Epilepsy

2 (3.4%)

1 (50.0%)

1 (50.0%)

Anemia (50.0%)

Sickle cell

1 (1.7%)

1 (100.0%)

-

-

5. Multiple births

47 (12.4%)

30 (63.8%)

17 (36.2%)

Extrauterine infection (19.1%), preeclampsia (8.5%), severe maternal condition (8.5%), antepartum stillbirth (6.4%), mid-to-late pregnancy bleeding (2.1%)

6. Preeclampsia

31 (8.2%)

8 (25.8%)

23 (74.2%)

Antepartum stillbirth (29.0%), extrauterine infection (29.0%), severe maternal condition (19.4%), multiple gestation (12.9%), chorioamnionitis (16.1%), fetal distress (9.7%), mid-to-late pregnancy bleeding (3.2%), fetal anomaly (3.2%)

7. Mid-to-late pregnancy bleeding

29 (7.7%)

10 (34.5%)

19 (65.5%)

Severe maternal condition (34.5%), antepartum stillbirth (27.6%), extrauterine infection (27.6%), chorioamnionitis (6.9%), fetal anomaly (3.4%), fetal distress (3.4%), multiple gestation (3.8%), preeclampsia (3.4%)

8. Fetal distress

14 (3.7%)

5 (35.7%)

9 (64.3%)

Extrauterine infection (35.7%), severe maternal condition (28.6%), preeclampsia (21.4%), fetal anomaly (7.1%), chorioamnionitis (7.1%), mid-to-late pregnancy bleeding (7.1%)

9. Chorioamnionitis

13 (3.4%)

1 (7.7%)

12 (92.3%)

Antepartum stillbirth (61.5%), extrauterine infection (46.2%), severe maternal condition (38.5%), preeclampsia (38.5%), mid-to-late pregnancy bleeding (15.4%), fetal distress (7.7%), fetal anomaly (7.7%), fetal anemia (7.7%)

10. Fetal anomaly

10 (2.6%)

2 (20.0%)

8 (80.0%)

Extrauterine infection (60.0%), antepartum stillbirth (20.0%), fetal distress (10.0%), preeclampsia (10.0%), mid-to-late pregnancy bleeding (10.0%), severe maternal condition (10.0%), chorioamnionitis (10.0%)

11. Fetal anemia

2 (0.5%)

1 (50.0%)

1 (50.0%)

Chorioamnionitis (50.0%), antepartum stillbirth (50.0%)

  1. aNumber of phenotypes: one (37.0%), two (20.7%), three (7.5%), four (3.1%), and five (1.8%)
  2. bConditions not mutually exclusive