Outcomes | Number of studies | Number of participants | WMD/OR (95%CI) | P | I2 |
---|---|---|---|---|---|
The first trimester | |||||
 Mean RI | 2 | 3158 | 0.06 (-0.04, 0.16) a | 0.233 | 97.40% |
  Sensitivity analysis |  |  | 0.06 (-0.04, 0.16) |  |  |
 Mean PI | 6 | 9694 | 0.31 (0.19, 0.44) a | < 0.001 | 86.50% |
  Sensitivity analysis |  |  | 0.31 (0.19, 0.44) |  |  |
 PI Z-score | 2 | 3629 | 0.30 (0.18, 0.42) a | < 0.001 | 0.00% |
  Sensitivity analysis |  |  | 0.30 (0.18, 0.42) |  |  |
The second trimester | |||||
 Notch presence | 9 | 10974 | 2.54 (2.10, 3.08) b | < 0.001 | 0.00% |
  Sensitivity analysis |  |  | 2.54 (2.10, 3.08) |  |  |
  Publication bias |  |  | Z = 0.36 | 0.974 |  |
 Mean PI | 4 | 3543 | 0.21 (0.12, 0.30) a | < 0.001 | 54.80% |
  Sensitivity analysis |  |  | 0.21 (0.12, 0.30) |  |  |
 Mean RI | 3 | 4141 | 0.05 (0.05, 0.06) a | < 0.001 | 47.10% |
  Sensitivity analysis |  |  | 0.05 (0.05, 0.06) |  |  |
The third trimester | |||||
 PI z-score | 5 | 2918 | 0.62 (0.33, 0.91) a | < 0.001 | 80.60% |
  Sensitivity analysis |  |  | 0.62 (0.33, 0.91) |  |  |
 PI MoM | 2 | 13492 | 0.08 (0.06, 0.09) a | < 0.001 | 2.90% |
  Sensitivity analysis |  |  | 0.08 (0.06, 0.09) |  |  |