Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy

Bosilah, Almandouh H.; Eldesouky, Elsayed; Alghazaly, Moatazza Mahdy; Farag, Elsayed; Sultan, Eslam Elsayed Kamal; Alazazy, Hosam; Mohamed, Attia; Ali, Soliman Mohamed Said; Elsror, Ahmed Gamal Abo; Mahmoud, Mohamed; Abd Elhalim, Abd Elhalim Mohamed; Kamel, Mohamed Abdelmonem; Abd-ElGawad, Mohamed; Sayed, Fatma Mohamed; Bakry, Mohamed Sobhy

doi:10.1186/s12884-023-05728-w

Table 3 Pairwise comparisons between the three groups in the continuous outcomes

From: Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy

Pairwise Comparisons
Dependent Variable	(I) Technique done	(J) Technique done	Mean Difference (I-J)	Std. Error	P – Value ^b	95% Confidence Interval for Difference
Dependent Variable	(I) Technique done	(J) Technique done	Mean Difference (I-J)	Std. Error	P – Value ^b	Lower Bound	Upper Bound
Operative time	Oxytocin	Tranexamic acid with ethamsylate	0.353	2.782	1.000	-6.346	7.052
	Oxytocin	Saline	0.071	2.810	1.000	-6.697	6.839
	Tranexamic acid with ethamsylate	Oxytocin	-0.353	2.782	1.000	-7.052	6.346
	Tranexamic acid with ethamsylate	Saline	-0.282	2.662	1.000	-6.692	6.128
	Saline	Oxytocin	-0.071	2.810	1.000	-6.839	6.697
	Saline	Tranexamic acid with ethamsylate	0.282	2.662	1.000	-6.128	6.692
Blood Loss	Oxytocin	Tranexamic acid with ethamsylate	21.499	23.650	1.000	-35.453	78.452
	Oxytocin	Saline	-43.414	23.892	0.211	-100.951	14.122
	Tranexamic acid with ethamsylate	Oxytocin	-21.499	23.650	1.000	-78.452	35.453
	Tranexamic acid with ethamsylate	Saline	-64.914^a	22.629	0.013	-119.407	-10.420
	Saline	Oxytocin	43.414	23.892	0.211	-14.122	100.951
	Saline	Tranexamic acid with ethamsylate	64.914^a	22.629	0.013	10.420	119.407
Preoperative HB	Oxytocin	Tranexamic acid with ethamsylate	-0.043	0.122	1.000	-0.336	0.250
	Oxytocin	Saline	-0.137	0.123	0.800	-0.433	0.159
	Tranexamic acid with ethamsylate	Oxytocin	0.043	0.122	1.000	-0.250	0.336
	Tranexamic acid with ethamsylate	Saline	-0.094	0.116	1.000	-0.374	0.187
	Saline	Oxytocin	0.137	0.123	0.800	-0.159	0.433
	Saline	Tranexamic acid with ethamsylate	0.094	0.116	1.000	-0.187	0.374
Preoperative HCT	Oxytocin	Tranexamic acid with ethamsylate	-0.129	0.368	1.000	-1.015	0.757
	Oxytocin	Saline	-0.541	0.372	0.439	-1.436	0.354
	Tranexamic acid with ethamsylate	Oxytocin	0.129	0.368	1.000	-0.757	1.015
	Tranexamic acid with ethamsylate	Saline	-0.412	0.352	0.727	-1.260	0.435
	Saline	Oxytocin	0.541	0.372	0.439	-0.354	1.436
	Saline	Tranexamic acid with ethamsylate	0.412	0.352	0.727	-0.435	1.260
Postoperative HB	Oxytocin	Tranexamic acid with ethamsylate	-0.039	0.186	1.000	-0.485	0.408
	Oxytocin	Saline	-0.098	0.187	1.000	-0.549	0.354
	Tranexamic acid with ethamsylate	Oxytocin	0.039	0.186	1.000	-0.408	0.485
	Tranexamic acid with ethamsylate	Saline	-0.059	0.177	1.000	-0.486	0.368
	Saline	Oxytocin	0.098	0.187	1.000	-0.354	0.549
	Saline	Tranexamic acid with ethamsylate	0.059	0.177	1.000	-0.368	0.486
Postoperative HCT	Oxytocin	Tranexamic acid with ethamsylate	-0.203	0.607	1.000	-1.663	1.258
	Oxytocin	Saline	0.135	0.613	1.000	-1.341	1.611
	Tranexamic acid with ethamsylate	Oxytocin	0.203	0.607	1.000	-1.258	1.663
	Tranexamic acid with ethamsylate	Saline	0.338	0.580	1.000	-1.060	1.735
	Saline	Oxytocin	-0.135	0.613	1.000	-1.611	1.341
	Saline	Tranexamic acid with ethamsylate	-0.338	0.580	1.000	-1.735	1.060
Change in HB	Oxytocin	Tranexamic acid with ethamsylate	0.004	0.171	1.000	-0.406	0.415
	Oxytocin	Saline	0.039	0.172	1.000	-0.376	0.454
	Tranexamic acid with ethamsylate	Oxytocin	-0.004	0.171	1.000	-0.415	0.406
	Tranexamic acid with ethamsylate	Saline	0.035	0.163	1.000	-0.358	0.428
	Saline	Oxytocin	-0.039	0.172	1.000	-0.454	0.376
	Saline	Tranexamic acid with ethamsylate	-0.035	0.163	1.000	-0.428	0.358
Change in HCT	Oxytocin	Tranexamic acid with ethamsylate	-0.074	0.595	1.000	-1.507	1.359
	Oxytocin	Saline	0.676	0.601	0.785	-0.772	2.124
	Tranexamic acid with ethamsylate	Oxytocin	0.074	0.595	1.000	-1.359	1.507
	Tranexamic acid with ethamsylate	Saline	0.750	0.569	0.567	-0.621	2.121
	Saline	Oxytocin	-0.676	0.601	0.785	-2.124	0.772
	Saline	Tranexamic acid with ethamsylate	-0.750	0.569	0.567	-2.121	0.621
Postoperative Hospital Stay	Oxytocin	Tranexamic acid with ethamsylate	-0.073	0.312	1.000	-0.824	0.678
	Oxytocin	Saline	0.076	0.315	1.000	-0.682	0.835
	Tranexamic acid with ethamsylate	Oxytocin	0.073	0.312	1.000	-0.678	0.824
	Tranexamic acid with ethamsylate	Saline	0.149	0.298	1.000	-0.570	0.868
	Saline	Oxytocin	-0.076	0.315	1.000	-0.835	0.682
	Saline	Tranexamic acid with ethamsylate	-0.149	0.298	1.000	-0.868	0.570

Table 3 shows the details of the pairwise comparison between the three groups in the continuous outcomes adjusted to the parity, previous CS, CS type, and the indication of CS
Based on estimated marginal means
HB Hemoglobin, HCT Hematocrit
^aThe mean difference is significant at the 0.05 level
^bAdjustment for multiple comparisons: Bonferroni

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ISSN: 1471-2393

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