Development and internal validation of a non-invasive clinical tool to predict sufficient omega-3 levels in early pregnancy

Table 6 Overall performance measures (95% confidence interval) for top five models

Model Predictors^*	Estimated n-3 intake (mg/week)	AUROC	Accuracy	Sensitivity	Specificity	Emax	Eavg	NRI	Brier’s Score	Scaled Brier’s Score
Dietary and supplementary intake of total n-3	767.8	0.744 (0.742–0.746)	0.722 (0.720–0.724)	0.847 (0.844–0.850)	0.547 (0.543–0.551)	0.160 (0.157–0.164)	0.072 (0.070–0.073)	0.197 (0.195–0.199)	0.200 (0.199–0.367)	0.170 (0.165–0.175)
Dietary and supplementary intake of total n-3 with 1.0% ALA conversion	797.0	0.741 (0.738–0.743)	0.714 (0.712–0.716)	0.837 (0.834–0.840)	0.544 (0.539–0.548)	0.160 (0.156–0.164)	0.071 (0.069–0.073)	0.190 (0.188–0.192)	0.202 (0.201–0.368)	0.162 (0.157–0.203)
Dietary and supplementary intake of total n-3 LCPUFA	630.1	0.742 (0.739–0.744)	0.710 (0.708–0.712)	0.870 (0.866–0.874)	0.488 (0.483–0.492)	0.163 (0.159–0.167)	0.072 (0.071–0.074)	0.179 (0.177–0.181)	0.200 (0.199–0.370)	0.173 (0.167–0.176)
Dietary and supplementary intake of total n-3 with 1.0% ALA conversion	670.9	0.733 (0.731–0.736)	0.694 (0.692–0.696)	0.845 (0.840–0.849)	0.484 (0.479–0.489)	0.160 (0.156–0.164)	0.072 (0.070–0.074)	0.164 (0.162–0.166)	0.204 (0.203–0.373)	0.153 (0.148–0.157)
Dietary and supplementary intake of total n-3 LCPUFA	558.1	0.732 (0.729–0.734)	0.689 (0.687–0.691)	0.851 (0.846–0.856)	0.465 (0.460–0.471)	0.164 (0.160–0.168)	0.073 (0.071–0.075)	0.158 (0.156–0.160)	0.204 (0.203–0.373)	0.154 (0.149–0.158)

^*All models were adjusted for maternal age, BMI, IRSAD and n-3 additions. Dietary intake refers to n-3 from food items whilst supplementary intake refers to n-3 from supplement use
Mg = milligrams; AUROC = area under the receiver operating characteristic; NRI = net reclassification improvement; n-3 = omega-3; ALA = alpha-linolenic acid

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