Fig. 5

Metabolic phenotype after Losartan administration. A: Fast glucose, fast insulin and HOMA-IR in HFD treatment male offspring after Losartan administration at 4, 10, 16 weeks (n = 10 respectively in two groups). B: Lipid profile of HFD treatment male offspring at 10,16 weeks after Losartan administration(Left: TC, n = 10 respectively in the two groups ; Middle: TG, n = 9 respectively in the two groups; Right: LDL, n = 9 respectively in the two groups). C: hepatic biochemical indexes of HFD treatment male offspring at 10,16 weeks after Losartan administration(Left: ALT, Middle: AST, Right: ALP; all n = 9 respectively in the two groups). ‘ns’ indicates a increased tend levels in IVF-HFD(0.05 < P < 0.1). D:Representative liver tissue sections were stained with H&E and ORO in HFD treatment male offspring after Losartan administration at 16 weeks (scale bar = 50 μm, from left to right: NC-HFD, IVF-HFD). ‘ns’ indicates a increased tend levels in IVF-HFD(0.05 < P < 0.1).