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Table 3 Unadjusted and adjusted odds ratios for the risk of gestational diabetes

From: Indirect effects of the COVID-19 pandemic on risk of gestational diabetes and factors contributing to increased risk in a multiethnic population: a retrospective cohort study

Characteristics

Univariate OR (95% CI)a

P-value

Multivariate OR (95% CI)a

P-value

Exposure period

 Pre-COVID-19

Reference

   

 COVID-19 Year 1

1.11 (1.02, 1.21)

0.02

1.05 (0.96, 1.15)

0.33

 COVID-19 Year 2

1.34 (1.23, 1.46)

 < 0.001

1.17 (1.06, 1.28)

0.01

Rate of 1st and 2nd trimester gestational weight gain (kg/week)

1.07 (0.95, 1.21)

0.3

1.31 (1.15, 1.49)

 < 0.001

Maternal age at conception

 < 20 years

0.34 (0.20, 0.56)

 < 0.001

0.39 (0.23, 0.66)

 < 0.001

 20–24.9 years

0.49 (0.41, 0.59)

 < 0.001

0.54 (0.44, 0.65)

 < 0.001

 25–34.9 years

Reference

   

 35–39.9 years

1.64 (1.52, 1.78)

 < 0.001

1.57 (1.44, 1.71)

 < 0.001

 40 years and over

1.96 (1.66, 2.32)

 < 0.001

1.92 (1.59, 2.31)

 < 0.001

Pre-pregnancy BMI categoryb

 Underweight

0.79 (0.64, 0.97)

0.03

0.84 (0.68, 1.05)

0.12

 Healthy weight

Reference

   

 Overweight

1.59 (1.46, 1.72)

 < 0.001

1.61 (1.48, 1.76)

 < 0.001

 Obese

1.86 (1.70, 2.05)

 < 0.001

2.10 (1.89, 2.33)

 < 0.001

Ethnicity

 Caucasian

Reference

   

 South Asian

2.27 (2.02, 2.55)

 < 0.001

2.24 (1.98, 2.53)

 < 0.001

 Middle Eastern

1.54 (1.36, 1.73)

 < 0.001

1.50 (1.32, 1.70)

 < 0.001

 East and Southeast Asian

1.95 (1.70, 2.23)

 < 0.001

2.14 (1.85, 2.47)

 < 0.001

 Aboriginal and Torres Strait Islander

1.42 (1.04, 1.94)

0.03

1.47 (1.05, 2.05)

0.03

Socioeconomic disadvantage: SEIFA quintilec

 Q1 (most disadvantaged)

1.20 (1.05, 1.38)

0.01

1.31 (1.13, 1.51)

 < 0.001

 Q2

1.16 (1.02, 1.320

0.02

1.06 (0.92, 1.22)

0.41

 Q3

1.10 (0.95, 1.270

0.21

1.01 (0.87, 1.18)

0.88

 Q4

0.99 (0.85, 1.16)

0.90

0.85 (0.72, 1.00)

0.05

 Q5 (least disadvantaged)

Reference

   

Nulliparity

0.98 (0.92, 1.06)

0.66

1.60 (1.48, 1.74)

 < 0.001

Prior history of gestational diabetes

6.25 (5.54, 7.06)

 < 0.001

6.05 (5.28, 6.92)

 < 0.001

First degree family member or sister with diabetes

1.73 (1.62, 1.86)

 < 0.001

1.40 (1.29, 1.50)

 < 0.001

Polycystic ovarian syndrome

1.60 (1.41, 1.83)

 < 0.001

1.33 (1.15, 1.53)

 < 0.001

  1. Odds ratios for COVID-19 pandemic period on risk of gestational diabetes in multivariate model adjusted for maternal age, pre-pregnancy body mass index, ethnicity, socioeconomic disadvantage, nulliparity, prior history of gestational diabetes, family history of diabetes, history of polycystic ovarian syndrome and first and second trimester gestational weight gain
  2. aOR Odds ratio, CI Confidence interval
  3. bBMI Body mass index in kg/m2
  4. cSEIFA Socio-Economic Indexes for Areas 2016 [16]