Table 2 Fetal CNS abnormalities diagnosed during first-trimester scans
Fetal CNS abnormality | Total | Increased NT | Diagnosis | Pregnancy outcome | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
11-14w | rate, % | 22-24w | 28-34w | ≥ 35w | Post-natal/MRI | TOP | Misc/IUD | LB | |||
Anencephaly | 5 | 5 | 100 | 0 | 0 | 0 | 5 | 0 | 0 | ||
Exencephaly | 22 | 1 | 22 | 100 | 0 | 0 | 0 | 22 | 0 | 0 | |
Meningoencephalocele | 4 | 1 | 4 | 100 | 0 | 0 | 0 | 3 | 1 | 0 | |
Holoprosencephaly | 14 | 11 | 79 | 2 | 1 | 0 | 14 | 0 | 0 | ||
Alobar | 5 | 5 | 100 | 0 | 0 | 0 | 5 | 0 | 0 | ||
Semi lobar | 8 | 6 | 75 | 2 | 0 | 0 | 8 | 0 | 0 | ||
Lobar | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | ||
Spina bifida | 9 | 2 | 22 | 3 | 3 | 0 | 1 | 5 | 0 | 4 | |
Open | 3 | 2 | 67 | 1 | 0 | 0 | 3 | 0 | 0 | ||
Closed | 6 | 0 | 0 | 2 | 3 | 0 | 1 | 2 | 0 | 4 | |
PFA | 10 | 1 | 2 | 20 | 5 | 1 | 1 | 1 | 5 | 0 | 5 |
Dandy-Walker | 1 | 1 | 100 | 0 | 0 | 0 | 1 | 0 | 0 | ||
Vermis hypoplasia | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | ||
Joubert Syndrome | 1 | 1 | 100 | 0 | 0 | 0 | 1 | 0 | 0 | ||
Cerebellar hypoplasia | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | ||
Blake’s cyst | 5 | 1 | 0 | 0 | 3 | 1 | 1 | 1 | 0 | 4 | |
Mega Cisterna Magna | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | |
Severe ventriculomegaly | 12 | 1 | 1 | 8 | 5 | 5 | 1 | 10 | 1 | 1 | |
Vein of Galen aneurysmal malformation | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | ||
Arachnoid cyst | 32 | 2 | 0 | 0 | 8 | 9 | 15 | 6 | 0 | 26 | |
Microcephaly | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | ||
Agenesis of the Corpus Callosum | 12 | 2 | 0 | 0 | 10 | 1 | 0 | 1 | 10 | 0 | 2 |
Intracranial infection | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | ||
Subependymal cyst | 19 | 0 | 0 | 0 | 13 | 6 | 1 | 0 | 18 | ||
Septum pellucidum cyst | 4 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 4 | ||
Isolated absence of septum pellucidum | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | ||
cerebral infarction | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | |
cortex dysplasia | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 0 | |